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Thomas Helm

Publications and source records attributed to Thomas Helm.

4 recordsLinked to original sources
PubMed2005

The vanishing biopsy: the trend toward smaller specimens.

Dermatopathologists have noted an increased number of smaller biopsy specimens. Our objective was to determine whether dermatologists are changing their choice of biopsy technique and the size of biopsy specimens. We conducted a retrospective study of 500 biopsies performed by dermatologists for the purpose of diagnosis in 1988, 1993, 1998, and 2003. Our study results indicate that dermatologists are performing fewer punch biopsies and more shave biopsies. What's more, there has been a decrease in the size of shave biopsy specimens. We believe that the decreased number of punch biopsies being performed combined with the decreased size of shave biopsy specimens may affect patient care.

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PubMed2004

Basic immunology: a primer.

This article is intended to bring practicing physicians up to date on the current state of knowledge regarding the basic components and processes of the immune system. It discusses the role of the immune system and the importance of self-tolerance and describes the main cellular and noncellular entities involved in the immune response. It also details immune processes such as the lymphocyte selection process leading to self tolerance; antigen processing and presentation; cell signaling, activation, and co-stimulation; and the actions of cytokines and other signaling molecules.

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PubMed2003

Successful treatment of extramammary Paget's disease with imiquimod.

Extramammary Paget's Disease (EMPD) is an uncommon neoplasm found in the genital, anorectal, or axillary area. Surgical excision is considered the standard treatment, although possible loss of tissue function and disease recurrence are seen. Other treatment modalities such as radiotherapy, topical chemotherapy, and photodynamic therapy are associated with varying degrees of effectiveness, but the search for an effective, safe treatment with minimal side effects proves to be challenging. We report a case where complete clinical and histological resolution of non-invasive EMPD of the penis was achieved with minimal adverse effects after six weeks of imiquimod (Aldara) application. As an immune system modifier that stimulates cytokine and interferon production, imiquimod may be a useful alternative or adjuvant in the treatment of EMPD.

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