Biomedical subjects

Thomas A Widiger

Publications and source records attributed to Thomas A Widiger.

22 records · Page 2Linked to original sources

PubMed2002

The borderline diagnosis I: psychopathology, comorbidity, and personality structure.

Borderline personality disorder (BPD) is a complex and serious mental disorder associated with severe functional impairment, substantial treatment utilization, and a high rate of mortality by suicide. Recently, BPD has become a focus of intensifying study. In Part I of this three-part article meant to provide a foundation to researchers on the current status of the borderline diagnosis and prospects for its future development, we examine the psychopathology, comorbidity, and personality structure of BPD. Although the descriptive characteristics of BPD are well-represented by DSM-IV diagnostic criteria, other important aspects of BPD psychopathology are not included. The descriptive criteria in conjunction with semistructured interviews have, however, increased the ability of investigators to diagnose BPD as reliably as many Axis I disorders. Frequent comorbidity of BPD with Axis I disorders necessitates a broad assessment of psychopathology to help account for clinical heterogeneity. Because of the absence of evidence of the validity of the diagnostic threshold for a categorical diagnosis of BPD, and because of the heterogeneity within the diagnosis, investigators should also supplement their DSM-IV diagnoses with assessments of underlying personality trait structures. Although there are a number of competing models of personality structure, they have remarkable convergence on a set of three to five basic personality dimensions.

Borderline Personality Disorder↗

PubMed2002

The borderline diagnosis II: biology, genetics, and clinical course.

In Part I of this three-part article, consideration of the core features of BPD psychopathology, of comorbidity with Axis I disorders, and of underlying personality trait structure suggested that the borderline diagnosis might be productively studied from the perspective of dimensions of trait expression, in addition to that of the category itself. In Part II, we review the biology, genetics, and clinical course of borderline personality disorder (BPD), continuing to attend to the utility of a focus on fundamental dimensions of psychopathology. Biological approaches to the study of personality can identify individual differences with both genetic and environmental influences. The aspects of personality disorder that are likely to have biologic correlates are those involving regulation of affects, impulse/action patterns, cognitive organization and anxiety/inhibition. For BPD, key psychobiological domains include impulsive aggression, associated with reduced serotonergic activity in the brain, and affective instability, associated with increased responsivity of cholinergic systems. There may be a strong genetic component for the development of BPD, but it seems clear, at least, that there are strong genetic influences on traits that underlie it, such as neuroticism, impulsivity, anxiousness, affective lability, and insecure attachment. The course of BPD suggests a heterogeneous disorder. Predictors of poor prognosis include history of childhood sexual abuse, early age at first psychiatric contact, chronicity of symptoms, affective instability, aggression, substance abuse, and increased comorbidity. For research purposes, at least, biological, genetic, and prognostic studies all continue to suggest the need to supplement categorical diagnoses of BPD with assessments of key underlying personality trait dimensions and with historical and clinical observations apart from those needed to make the borderline diagnosis itself.

Affect↗

PubMed2002

Maladaptive personality functioning within the big five and the five-factor model.

The five-factor model (FFM) of general personality functioning was derived originally from lexical studies of trait terms within the English language. Many studies have been conducted on the relationship of the FFM to personality disorder symptomatology but, as yet, no lexical study of the representation of maladaptive personality functioning within a language has been conducted. The current study identified the distribution of socially undesirable trait terms within each of the poles of the Big Five and compared this distribution to findings obtained with FFM personality disorder measures. The implications of the results for a FFM of personality disorders and for the FFM assessment of maladaptive personality functioning are discussed.

Adaptation, Psychological↗

PubMedDate not supplied

A dimensional model of psychopathology.

The question of whether mental disorders are discrete clinical conditions or arbitrary distinctions along dimensions of functioning is a longstanding issue, but the importance of this question is escalating with the growing recognition of the frustrations and limitations engendered by the categorical model. Researchers are now focusing their attention on developing alternative dimensional models of classification. Concerns have been raised with regard to these dimensional models. Addressed in this brief commentary are two of these concerns: clinical utility and credibility.

Diagnosis, Differential↗