Biomedical subjects

Thiago Dos Santos Rosa

Publications and source records attributed to Thiago Dos Santos Rosa.

4 recordsLinked to original sources

PubMed2026

Association between sirtuin 1 and markers of oxidative stress in master athletes.

BACKGROUND: Lifelong training in master athletes confers protective effects, promoting higher sirtuin levels and enhanced antioxidant capacity. Although Sirtuin 1 (SIRT1) is well studied, no previous study has examined the relationship between circulating SIRT1 levels and antioxidant defense variables in master athletes. PURPOSE: To compare and analyze the relationships between circulating levels of SIRT1 and variables related to antioxidant defense in master athletes (MA) and untrained middle-aged individuals (UMA). METHODS: Male MA (n = 42; 51.62 ± 7.33 years; ≥10 years of training and competition in running) and UMA (n = 15; 47.73 ± 8.52 years) were evaluated. Venous blood samples were collected for biochemical analyses of SIRT1, antioxidant enzymes, TBARS and F2-isoprostanes, 8-OHdG, and redox balance indexes. RESULTS: MA showed higher levels of SIRT1 (18.22 ± 4.53 vs. 6.08 ± 2.11 ng/mL; p < 0.0001), as well as of SOD, CAT, and GSH (p < 0.001), indicating a more favorable antioxidant profile. After adjustment for body fat percentage, differences in SOD, CAT, GSH and TBARS, remained significant. SIRT1 was positively correlated with SOD (r = 0.279; p = 0.031), CAT (r = 0.485; p < 0.001), GSH (r = 0.476; p < 0.001) and CAT/8-OHdG (r = 0.430; p = 0.032), and negatively correlated with TBARS (r = - 0.518; p < 0.001). CONCLUSION: Master athletes exhibited higher circulating SIRT1 concentrations and a more favorable systemic redox profile than untrained individuals, with SIRT1 being associated with markers of antioxidant defense, lipid peroxidation, and redox balance.

Aging↗

PubMed2026

Comparative adipokine profile in middle-aged master athletes, untrained adults, and young individuals.

BACKGROUND: Adipose tissue is an active endocrine organ involved in metabolic regulation and systemic inflammation, processes that are altered during aging. Nevertheless, the adipokine profile associated with lifelong physical training in master. athletes remains incompletely characterized. AIM: This study investigated circulating concentrations of adiponectin, leptin, resistin, insulin, and the leptin-to-adiponectin and adiponectin-to-resistin ratios in four male groups: endurance master athletes (ME), master sprinters (MS), untrained middle-aged adults (UMA), and untrained young adults (YU). METHODS: ME (n = 17, 50.5 ± 9.6 years), MS (n = 30, 50.3 ± 6.2 years), UMA (n = 16, 48.5 ± 7.5 years), and YU (n = 23, 23.7 ± 4.0 years) underwent anamnesis, anthropometric assessments, and serum concentrations of adiponectin, leptin, resistin, and insulin using commercial ELISA kits. RESULTS AND DISCUSSION: Significant group differences were observed for all variables (p < 0.001). UMA exhibited higher concentrations of leptin, insulin, and resistin, together with an elevated leptin-to-adiponectin ratio and a reduced adiponectin-to-resistin ratio compared with the other groups (p < 0.05). MS also presented higher leptin and insulin levels and an increased leptin-to-adiponectin ratio compared. with YU (p < 0.05), as well as a lower adiponectin-to-resistin ratio (p < 0.05). Overall, effect sizes were large across outcomes, and master athletes displayed a more favorable adipokine profile than untrained middle-aged adults, suggesting potential metabolic adaptations associated with lifelong training. CONCLUSIONS: Middle-aged master athletes exhibited a more favorable adipokine profile than untrained middle-aged adults, with values approaching those observed in young individuals.

Adipose tissue↗

PubMed2026

Dose-response effects of isometric wall squats on postexercise hypotension in older women with hypertension.

OBJECTIVES: The isometric wall squat (IWS) is a promising nonpharmacological intervention for blood pressure (BP) management, but its optimal dosage in older adults remains unclear. This study compared postexercise hypotension (PEH) after two IWS doses in medicated older women with systemic arterial hypertension (SAH). METHODS: Thirty older hypertensive women (68.8 ± 10.0 years) were randomized into three groups: control (CG), 8-min IWS (G8-IWS; 4 × 2-min sets), and 12-min IWS (G12-IWS; 6 × 2-min sets). BP and heart rate (HR) were assessed at rest and at 0, 5, 10, 15, 30, 45, and 60 min postexercise and analyzed using linear mixed-effects models with Bonferroni correction ( P  < 0.05). RESULTS: G12-IWS significantly reduced systolic BP and mean arterial pressure (MAP) at 45-60 min and 30-60 min postexercise ( P  < 0.05), while G8-IWS showed no BP changes. G12-IWS decreased HR (30-60 min) and rate-pressure product (RPP; 15-60 min); G8-IWS reduced RPP from 30 to 60 min only. Diastolic BP and pulse pressure remained unchanged in both groups. CONCLUSION: A single G12-IWS session induced clinically meaningful PEH (~8-10 mmHg), exceeding reported with isometric handgrip exercise (~4-6 mmHg), with greater RPP suppression than G8-IWS. This equipment-free protocol represents a relevant nonpharmacological strategy for BP management in older women with SAH.

Humans↗

PubMed2025

Exercise Therapy in Down Syndrome: A Systematic Review and Meta-Analysis Focused on Muscle Strength, Redox Balance, and Inflammatory Profile.

OBJECTIVE: This study systematically reviewed and meta-analyzed randomized and quasi-randomized controlled trials investigating the impact of exercise therapy on muscle strength, redox balance, and inflammatory profile in individuals with Down syndrome. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Cochrane Central Register of Controlled Trials, MEDLINE, CINAHL, SPORTDiscus, EMBASE, and PEDro. ELIGIBILITY CRITERIA FOR SELECTING STUDIES: Randomized and quasi-randomized controlled trials exploring exercise therapy effects on muscle strength and redox balance in individuals with Down syndrome. Although no initial restrictions on age, gender, or health condition were applied during the search process, all included studies focused on adult participants (>18 yr old). No language restrictions were applied, and the search covered the period from 1970 to 2021. RESULTS: We assessed the abstract of 1964 studies. Of the 46 studies meeting the inclusion criteria for the period 2004-2021, 32 focused on muscle strength, and 14 examined redox balance and inflammation. A total of 1611 participants with a mean age of 27 yr were included. This review confirmed that different exercise modalities are prone to improve muscle strength (random effect (95% confidence interval): 0.66, 0.54 to 0.78), redox balance and inflammatory profile (random effect (95% confidence interval): -1.04, -1.31 to -0.76) in this population. The multimodel inference suggested that the frequency of training (times per week) might play a significant role in the main effect. Unsupervised machine learning algorithms displayed a pattern-based graphic representation to assess heterogeneity. CONCLUSIONS: Exercise training demonstrated a positive impact on muscle strength in adults with Down syndrome. The review provides valuable insights into the effects of exercise therapy on individuals with Down syndrome, emphasizing the need for tailored training prescriptions.

Humans↗