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Teruhisa Kazui

Publications and source records attributed to Teruhisa Kazui.

61 records · Page 4Linked to original sources
PubMed2002

Usefulness of antegrade selective cerebral perfusion during aortic arch operations.

BACKGROUND: To evaluate the safety and usefulness of antegrade selective cerebral perfusion (SCP) during arch aneurysm or aortic dissection operations. METHODS: Between January 1986 and December 2001, 330 patients underwent aortic arch repair using SCP. Operations were performed with the aid of hypothermic extracorporeal circulation, SCP, and systemic circulatory arrest in most cases. In all, 89 patients (27%) were operated on for acute aortic dissection, 77 (23%) for chronic aortic dissection, and 164 (50%) for degenerative aneurysm. Total arch replacement using a branched graft was performed in 288 patients (94%). Mean SCP time was 86.2 +/- 28.5 minutes. RESULTS: The overall in-hospital mortality rate was 11.2% (falling to 3.2% in the 124 patients operated on between 1997 and 2001). Independent determinants of hospital mortality were pump time, renal/mesenteric ischemia, chronic renal failure, increasing age, period of operation, and nonuse of four-branched arch graft. The overall postoperative incidences of temporary and permanent neurologic dysfunction were 4.2% and 2.4%, respectively. There was no significant correlation between SCP time and in-hospital mortality or neurologic outcome. CONCLUSIONS: Selective cerebral perfusion is a reliable technique for cerebral protection and it facilitates complex and time-consuming total arch replacement.

Adolescent↗
PubMed2002

Impact of an aggressive surgical approach on surgical outcome in type A aortic dissection.

BACKGROUND: To evaluate the impact of an aggressive surgical approach on early and late outcome in type A aortic dissection. METHODS: From 1983 to 2001, 240 patients underwent operation for acute (n = 138) and chronic (n = 102) type A aortic dissection. The extent of distal aortic resection included the ascending aorta in 39 (16%) patients, hemiarch (HAR) in 47 (20%), and total arch (TAR) in 154 (64%), including 19 patients who also had their descending aorta replaced (DAR). RESULTS: The in-hospital mortality did not differ between TAR with or without DAR and other more conservative techniques (12.3% versus 16.3%). Actuarial survival at 10 years including in-hospital mortality was 72.4% +/- 3.3% and freedom from reoperation was 77.2% +/- 3.6% for all patients: neither was influenced by the extent of distal aortic resection or acuity of aortic dissection. Multivariate analysis revealed younger age and failure to resect the intimal tear to be independent determinants for late reoperation. However, in contrast to 22 patients who had more conservative operations, none of the patients with TAR required reoperation on the aortic arch through a sternotomy incision. CONCLUSIONS: An aggressive surgical approach did not adversely influence early and late survival following type A aortic dissection; it reduced the necessity of late reoperation and facilitated distal aortic reoperation.

Adult↗
PubMed2002

Histological changes in canine aorta 1 year after stent-graft implantation: implications for the long-term stability of device anchoring zones.

PURPOSE: To examine aortic histology 1 year after stent-graft implantation in a canine model as a means of assessing the durability of endograft fixation. METHODS: Fourteen mongrel dogs each received 1 stent-graft and 1 bare stent placed endoluminally in the abdominal aorta. Eight animals were followed for 1 year, 3 for 4 to 8 weeks, and the remaining 3 for 24 to 48 hours. Aortic specimens were stained with hematoxylin-eosin, elastica-van Gieson, and Masson's trichrome and examined with light and electron microscopy and immunohistochemistry to identify smooth muscle cells (SMC), endothelialization, aortic wall ultrastructure, and changes at the device anchoring sites. RESULTS: No dilatation or dissection was noted at any of the device anchoring sites. The aortic media at 1 year was remarkably decreased in thickness: 891 +/- 196 microm in the control tissue versus 388 +/- 70 microm for the proximal stent-grafted aorta and 457 +/- 148 microm for the bare-stented aortic segment. Other important histological features were reduced elastic lamellae in the stent-grafted aorta versus control (p<0.0001), increased SMC density in the stent-grafted aortic region (p<0.0001 versus control), and absence of inflammatory infiltrate. Complete neointimal covering and endothelialization of the luminal endograft surface were found. SMCs generally showed no ultrastructural features of necrosis. CONCLUSIONS: Aortic stent-grafts induce distinctive histological changes in the aortic wall at 1 year, even when implanted in a healthy aorta. Although there is considerable medial elastin loss, an increased medial SMC density, an exuberant neointima, and a general absence of perigraft inflammation suggest an ongoing process of structural restoration at the device anchoring sites.

Animals↗
PubMed2002

Simultaneous carotid endarterectomy, coronary artery bypass grafting and abdominal aortic aneurysm surgery.

A case with a disease triad of an ulcerative lesion in the left internal carotid artery (LICA), severe coronary insufficiency, and an infrarenal abdominal aortic aneurysm (AAA) is presented in whom we performed simultaneous carotid endarterectomy (CEA), coronary artery bypass grafting (CABG), and Y-graft replacement of the AAA. The operative technique is detailed and justification of the simultaneous approach in such patients is discussed.

Aortic Aneurysm, Abdominal↗
PubMedDate not supplied

A highly polymorphic CA repeat marker at the EBAG9/RCAS1 locus on 8q23 that detected frequent multiplication in breast cancer.

BACKGROUND: Cloning of CpG binding sites in the human genome initially identified EBAG9 (estrogen receptor-binding fragment-associated gene 9), an estrogen-responsive gene mapped to chromosome 8q23. Its product was later found to be identical to RCAS1 (receptor-binding cancer antigen expressed on SiSo cells 1). RCAS1 was recently described as a cancer-surface antigen, implicated in immune escape in a human uterine adenocarcinoma cell line, which turned out to be identical to the EBAG9 molecule. AIM: The study seeks to isolate a highly polymorphic dinucleotide repeat at this locus that detects frequent multiplication of the EBAG9/RCAS1 gene. SUBJECT AND METHODS: A fragment containing CA repeat was identified by Southern blotting of bacterial artificial chromosome (BAC) clone containing the EBAG9/RCAS1 gene digested by Hae III, Sau 3A or Rsa I with (GT)20 probe, subcloned and sequenced. RESULTS: We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the EBAG9/RCAS1 gene located at 8q23. High heterozygosity (0.859) makes this polymorphism a useful marker in genetic studies. This marker detected frequent multiplication of the EBAG9/RCAS1 gene in primary breast cancers (27 of 129 tumours). CONCLUSION: This marker is useful for detecting frequent multiplication of the EBAG9/RCAS1 gene in primary breast cancers and other cancers.

Alleles↗