Biomedical subjects
Publications and source records attributed to Takashi Kurokawa.
A novel interferometry technique using a frequency-comb light source is proposed for surface profilometry and tomography of discontinuous objects. Surface profile measurement is performed by sweeping the comb interval frequency without mechanical scanning. Step heights of 0.5 and 1.0 mm are successfully measured by use of the scheme with 9 mum accuracy.
A three-dimensional common-path interferometer is proposed, which can achromatically null out an on-axis source while it maintains the detectability of an off-axis source. A geometric phase in the three-dimensional interferometer introduces an achromatic pi-phase shift to the light from the on-axis source, such that destructive interference nulls out the axial light at one of the ports of the interferometer. Light from the off-axis source, which is exempt from the pi-phase shift, comes out from both ports with equal intensity. The common-path scheme makes the system highly immune to environmental disturbances.
[reaction: see text] N-Tosyl 3-substituted indoles were hydrogenated with high enantioselectivities (95-98% ee) by use of a trans-chelating chiral bisphosphine, (S,S)-(R,R)-PhTRAP ligand. The chiral catalyst, which was generated in situ from [Rh(nbd)(2)]SbF(6), PhTRAP, and Cs(2)CO(3), is useful for enantioselectively synthesizing a range of diverse optically active indolines possessing a chiral carbon at the 3-position.
This paper discusses fiber optic power and signal transmission systems considering the application of dc powering to information tools such as personal computers. We discuss system requirements and technical issues for the system components, including high-power laser diodes and photovoltaic cells. It is clarified that the conversion efficiencies of photovoltaic cells are kept constant with heat radiation and improve with extremely small series resistance. The transmittable optical powers through the optical fiber limited by a nonlinear optical effect are estimated. We also discuss the system designs for the use of single- and multi-mode optical fibers.
A novel profilometry method based on two-photon absorption in a silicon avalanche photodiode is proposed. This method has a wide dynamic range, from millimeters to tens of meters. The principle is experimentally confirmed with a fiber-optic Mach-Zehnder interferometer.
A nonmechanical scanning Mirau-type spectral interference microscope has been developed for the measurement of three-dimensional surface profiles of discontinuous objects. An acousto-optic tunable filter (AOTF) is used as a high-resolution spectral filter, which scans the optical frequency of the broadband light emitted from a superluminescent diode. To generate spectral fringes that make full use of the limited coherence length of the filtered light we unbalanced the Mirau interferometric system by positioning the reference mirror nearly halfway between the top and the bottom of the step height. When the frequency of the broadband light source is scanned by an AOTF, the interference fringes move in opposite directions on the top and the bottom of the object. To uniquely determine the sign of the fringe movement over the large area of the object, we developed a three-dimensional Fourier-transform technique, and from the detected sign of the fringe movement and phase information, we determined the three-dimensional step height. Experimental results of the measurement of 100-microm step height are presented. The main advantages of the proposed system are that it provides nonmechanical scanning and a large measurement range without ambiguity in the sign of the phase.
The maximum measurable range of a spectral interference microscope depends on the coherence length of the light transmitted by its tunable spectral filter. To achieve a large range in step-height measurement we have developed a new tunable spectral filter that uses tandem liquid-crystal Fabry-Perot interferometers (LC-FPIs), which can simultaneously attain both a high spectral resolution and a large tuning range. Fringe visibility measurements were carried out, and it was found that the coherence length of the light transmitted through tandem LC-FPIs is two times larger than that transmitted through a single LC-FPI. Using this novel tunable spectral filter, we developed a new spectral interference microscope for the measurement of three-dimensional shapes of discontinuous objects. Experimental results of step-height measurements both with a single LC-FPI and with tandem LC-FPIs are presented for a combination of standard steel gauge block sets with 1-, 99-, and 100-microm steps. A large range (1-100 microm) of measurement with submicrometer resolution was achieved with tandem LC-FPIs that was not possible with our previous system in which a single LC-FPI was used.
The purpose of this study was to observe the change in double product with increases in the intensity of bicycle exercise. Eleven young male adults participated in this study. The subjects performed graded bicycling exercise increasing 20 watts every 2 min from 0 watts until the heart rate (HR) reached 170 beats.min(-1). During exercise systolic blood pressure (SBP) and HR were continuously measured. Initially SBP gradually increased with the increase in workload, but when the intensity of exercise became even higher, the rate of increase slowed. On the other hand, the increase in HR was very small during the initial 5 min of exercise and when the intensity of exercise increased, the rate of increase of HR became higher. The polygonal regression analyses on the relation of double product to elapsed time revealed clear break-points. On average, the break-point of double product was 6.6 min (56 watts). These results clearly showed that the break-point of double product with an increase in workload appeared even though the workload was relatively low.
A case of papillary adenocarcinoma of the prostate is reported. A 73-year-old man was referred to our hospital with macrohematuria. The serum level of the PSA ranged within normal limits. Urethroscopy revealed a papillary tumor near the verumontanum. The tumor was resected transurethrally. Histopathological examination revealed adenocarcinoma with papillary growth and the tumor displayed immunoreactivity for PSA stain. Radical prostatectomy was performed. The follow-up at 11 months revealed neither local recurrence nor distant metastases.
A noncontact, nonmechanical scanning, wide-field spectral interference microscope is developed for simultaneous measurement of three-dimensional step-height of discontinuous objects and tomographic imaging. A superluminescent diode (SLD) is used as a broadband light source and a liquid-crystal Fabry-Perot interferometer (LC-FPI) as a frequency-scanning device. By means of changing the injection current to the SLD, the spectral profile of the SLD is equalized, and a constant light input to the interferometer is achieved over the entire frequency-scan range. The Fourier-transform technique is used to determine both the amplitude and the phase of spectral fringe signals. Three-dimensional height distribution of a discontinuous object is obtained from the phase information, whereas optically sectioned images of the object are obtained either from the amplitude information alone or from the combination of both the amplitude and phase information. Experimental results with submicrometer resolution are presented for both step-height measurement and tomographic sectioning.