Biomedical subjects

Tag Heo

Publications and source records attributed to Tag Heo.

5 recordsLinked to original sources

PubMed2005

A case of osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma: histopathological, immunohistochemical, ultrastructural and molecular biological studies.

Osteoclast-like giant cell tumor of the pancreas is a very rare neoplasm, of which the histiogenesis remains controversial. A 63-yr-old woman was hospitalized for evaluation of epigastric pain. An abdominal computerized tomography revealed the presence of a large cystic mass, arising from the tail of pancreas. A distal pancreatectomy with splenectomy was performed. Histologically, the tumor was composed of mononuclear stromal cells intermingled with osteclast-like giant cells. In addition, there was a small area of moderately to well differentiated ductal adenocarcinoma. The final pathologic diagnosis was osteoclast-like giant cell tumor of the pancreas with ductal adenocarcinoma. Here, we describe the histopathological, immunohistochemical, ultrastructural and molecular biological findings of this tumor with review of the literature pertaining to this condition.

Antigens, CD↗

PubMed2004

Expression of brain-specific angiogenesis inhibitor 3 (BAI3) in normal brain and implications for BAI3 in ischemia-induced brain angiogenesis and malignant glioma.

Murine brain-specific angiogenesis inhibitor 1 and 2 (mBAI1, mBAI2) are involved in angiogenesis after cerebral ischemia. In this study, mBAI3 was cloned and characterized. Northern and Western blot analyses demonstrated a unique developmental expression pattern in the brain. The level of mBAI3 in brain peaked 1 day after birth, unlike mBAI1 and mBAI2, which peaked 10 days after birth. In situ hybridization analyses of the brain showed the same localization of BAI3 as BAI1 and BAI2, which includes most neurons of cerebral cortex and hippocampus. In the in vivo focal cerebral ischemia model, BAI3 expression decreased from 0.5 h after hypoxia until 8 h, but returned to control level after 24 h. The expression of vascular endothelial growth factor following ischemia showed an inverse pattern. The decreased expressions of BAIs in high-grade gliomas were observed, but BAI3 expression was generally lower in malignant gliomas than in normal brain. Our results indicate that the expression and distribution of BAI3 in normal brain, but not its developmental expression, are very similar to those of BAI1 and BAI2, and that BAI3 may participate in the early phases of ischemia-induced brain angiogenesis and in brain tumor progression.

Amino Acid Sequence↗

PubMed2004

Penile strangulation treated with the modified string method.

Penile strangulation by a nonmetallic or thin metallic ring is easily overcome by severing the object, but a heavy metal ring causing penile strangulation is very difficult to sever. Here we report 2 cases of penile strangulation by metal rings, involving a 38-year-old man and a 44-year-old man, both of whom were treated with the modified string method and glandular puncture.

Adult↗

PubMed2004

Effect of human RAD50 gene therapy on glaucoma filtering surgery in rabbit eye.

PURPOSE: To investigate the antiproliferative effects of the subconjunctival injection of human RAD50 (hRAD50) on fibroblasts after glaucoma filtering surgery. METHODS: After glaucoma filtering surgery in normal rabbit eye, the subconjunctival injection of hRAD50 was performed. Morphologic changes in the subconjunctival area of hRAD50-treated eyes were compared with those of mitomycin C (MMC)-treated and control eyes using light and electron microscopy. Results. Two weeks after hRAD50 treatment (2 microg), the conjunctival epithelium increased in thickness and had many tonofilaments, but the basal lamina was intact. The subconjunctival fibroblasts exhibited a granular endoplasmic reticulum without distension. Most of the collagen bundles and fibers around the fibroblasts disappeared, and apoptotic cells with many fragmented nuclei and condensed chromatin were observed. Four weeks after hRAD50 treatment, the findings were similar with those of 2 weeks except for a slight increase in the number of collagen bundles and fibers and the appearance of macrophages. In MMC-treated eyes, the conjunctival epithelium also increased in thickness and had many tonofilaments. However, intercellular spaces were widened and the basal lamina was interrupted in some areas. Most of the collagen bundles and fibers were shortened, and apoptotic cells were also observed. CONCLUSIONS: These results demonstrate that the histologic antiproliferative effects of local hRAD50 on the conjunctival fibroblasts are similar to those of MMC, but without damage to the basal lamina of the conjunctival epithelium, and suggest that hRAD50 may be useful as a possible antifibroblastic agent for glaucoma filtering surgery. However, further investigations are needed to test for possible systemic complications, which so far have not been reported.

Animals↗

PubMed2003

Excitatory effects of 5-hydroxytryptamine on the medial vestibular nuclear neuron via the 5-HT2 receptor.

This study was designed to investigate the mechanisms of action of the 5-HT2 receptor on the spontaneous electrical activity and potassium currents of the rat medial vestibular nuclear neurons using whole-cell patch clamp recordings. The spike width of spontaneous action potential was not affected by 5-alpha-methylhydroxytryptamine. The spike frequency and resting membrane potential was increased by 5-alpha-methylhydroxytryptamine. The amplitude of afterhyperpolarization was decreased by 5-alpha-methylhydroxy-tryptamine. The peak current of the potassium currents of the neuron treated with 5-alpha-methylhydroxytryptamine was decreased. After blockade of calcium-dependent potassium currents, 5-alpha-methylhydroxytryptamine did not inhibit potassium currents. These results suggest 5-alpha-methylhydroxytryptamine increases spontaneous firing of the medial vestibular nuclear neurons by inhibiting calcium dependent potassium currents.

Action Potentials↗