Search PubMed⌕ Search

Biomedical subjects

T Yanagawa

Publications and source records attributed to T Yanagawa.

At least 199 records · Page 11Linked to original sources
PubMed1979

[Effects of orciprenaline on the responses to Ca, K, acetylcholine and Ba in the isolated seminal vesicles of guinea pigs, especially in relation to cyclic AMP (author's transl)].

By using the isolated seminal vesicles of guinea pigs, the effects of dibutyryl cyclic AMP and beta-stimulant, orciprenaline, on the responses to Ca, K, acetylcholine and Ba were investigated, especially in relation to cyclic AMP. The following results were obtained. 1. Orciprenaline inhibited the contraction produced by Ca, K, acetylcholine and Ba in a dose-dependent manner, and the inhibition became larger in the order of Ca, K, acetylcholine and Ba. 2. Dibutyryl cyclic AMP showed the same results as those of orciprenaline. That is, dibutyryl cyclic AMP inhibited the contractions produced by acetylcholine and Ba. 3. Orciprenaline showed the increased level of cyclic AMP in a dose-dependent manner. But the increase was not remarkable in the concentration in which the contractions produced by the tested contractile agents were inhibited by about 50%. From these results, the following suggestions were obtained; (1) there exists beta-receptor in guinea pig seminal vesicles and (2) a part of actions of orciprenaline is due to a mechanism unrelated to cyclic AMP.

Acetylcholine↗
PubMed1978

A possible mechanism of infertility by acute cadmium intoxication.

A possible mechanism of infertility by Cd was investigated from the standpoint of influence of Cd on the contractile responses of isolated seminal vesicle from guinea pigs to K, acetylcholine, noradrenaline, Ba and Ca by using the Magnus method. Cd inhibited the contractile responses to the contractile agents tested in a dose-dependent manner. Cd showed the preferential inhibition against the contractile responses to K and Ca. The inhibitory effect of Cd on the contractile responses to noradrenaline and acetylcholine was hardly removed. The effect of Cd was inhibited by the thiol compounds, glutathione and thiola. The active mechanism of Cd was discussed in relation to Ca mobilization.

Acetylcholine↗