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Biomedical subjects

T Y Wang

Publications and source records attributed to T Y Wang.

At least 19 recordsLinked to original sources
PubMed1992

Comparative study of the prognostic value of nuclear grade and silver-binding nucleolar organizer region in renal cell carcinomas.

Silver-binding nucleolar organizer region (AgNOR) and nuclear grade were histologically assessed in 112 renal cell carcinomas. Nuclear grade was better capable of stratification than AgNOR in terms of survival prediction. It also had prognostic significance when total metastatic rates were evaluated. Although higher mean AgNOR numbers were constantly associated with higher nuclear grades, two arbitrary classifications of AgNOR (less than 1.5, 1.5-3.5, greater than 3.5; less than 2, 2-3, greater than 3) failed to resolve the survival difference.

Carcinoma, Renal Cell↗
PubMed1992

[Effect of mexiletine on energy metabolism of ischemic brain in mice].

After 30 s ischemia induced by decapitation, the contents of ATP and phosphocreatine (PC) in mouse brain reduced, while that of lactic acid (LA) increased. When mexiletine (3.1-50 mg.kg-1) was injected ip 30 min before decapitation, the brain ATP and PC reduction, and LA accumulation were both alleviated in a dose-dependent manner. These findings suggested that mexiletine was effective in ameliorating the energy exhaustion in the ischemic brain.

Adenosine Triphosphate↗
PubMed1991

c-myc and K-ras-2 oncogenes in B-cell chronic lymphocytic leukemia with del(12)(p13).

Molecular and cytogenetic analyses were performed on chronic B-lymphocytic cell leukemia (CLL) from a 57-year-old male patient with del(12)(p13) anomaly. The deletion did not remove the K-ras-2 gene. However, c-myc gene amplification correlated with high-level expression, suggesting the involvement of this gene in the induction of neoplasia in this patient.

Chromosome Deletion↗
PubMed1991

[Late-stage prosthetic valve infective endocarditis. Report of 2 cases].

Two patients with prosthetic valve infective endocarditis underwent second valve replacement after long-term medication. One patient died and the other survived. Bioprosthetic valve infection developed gradually with late appearance of valve dysfunction. We suggest surgical intervention because of poor results of medication. During the reoperation, the infected tissue should be removed thoroughly and new prosthetic valve be tightly sutured with special attention to prevention of bleeding.

Adult↗
PubMed1990

Burkitt's lymphoma of the testicle: report of 2 cases occurring in elderly patients.

Burkitt's lymphoma is rare in patients older than 50 years and almost never presents as a testicular tumor. We report 2 cases of primary Burkitt's lymphoma of the testicle in men 68 and 79 years old. In 1 man the extragonadal tumor had a rapid and lasting response to combination chemotherapy. The cases are of interest for the unusual presentation of the disease and for the possibility to control Burkitt's lymphoma in older patients without undue toxicity. The management of testicular lymphoma requires radical orchiectomy and prophylactic irradiation of the contralateral testis. Chemotherapy is indicated for advanced disease and may prevent relapses in patients with early disease. The role of central nervous system prophylaxis is controversial.

Aged↗
PubMed1990

Changes in the cochlear iron enzymes and adenosine triphosphatase in experimental iron deficiency.

The influences of iron deficiency on the cochlear iron enzymes and adenosine triphosphatase were studied in 68 iron-deficient rats and 68 control rats (normal and with chronic anemia). A disorderly or topographic distribution and reduction or disappearance of the cochlear succinic dehydrogenase and peroxidase reaction products were found in 37.8% of the rats fed on a basic iron-deficient diet for 14 to 100 days. The activity of cochlear sodium-potassium-dependent adenosine triphosphatase in iron-deficient rats was slightly increased, compared to that in normal controls. These results suggest that iron deficiency would produce significant abnormalities of succinic dehydrogenase and peroxidase activity, which in turn would disturb cell respiration and initiate peroxidative damage to the inner ear cells, result in sensorineural hearing loss, or provide a pathologic basis for cochlear deafness.

Anemia, Hypochromic↗
PubMed1990

Papillary cystadenocarcinoma of the epididymis--report of a case.

A papillary cystadenocarcinoma of epididymis with right paraureteral metastases in a 27-year-old man is presented. It was a 14x13x8 cm cystic mass in the right testicular adnexa which had been noted for more than 10 years. From its prolonged clinical course and the morphological findings, this tumor was thought to be a malignant transformation from previously benign lesion--papillary cystadenoma. Review of the literature disclosed that it is a very rare malignancy arising from the testicular adnexa.

Adult↗
PubMed1990

[Chylothorax after cardiothoracic surgery].

8 patients with postoperative chylothorax were reported: 7 after resection of esophageal carcinoma, 1 after radical correction of tetralogy of Fallot. 1 case was treated conservatively and 7 by ligation of thoracic duct after rethoracotomy. All the cases recovered. The factors causing postoperative chylothorax, the principles of treatment, and the role of prophylactic ligation of thoracic duct were discussed. The authors point out that, the mechanisms of postoperative chylothorax after open heart surgery by sternotomy may be: (1) injury of perithymotic and anterior mediastinal lymph ducts; (2) injury of thoracic duct through posterior wall of pericardium; and (3) effect of hypertension of systemic veins on flow of thoracic duct.

Adolescent↗
PubMed1989

Metastatic carcinoma of unknown primary: complete response to second-line treatment with plicamycin.

In selected groups of patients, metastatic carcinoma of unknown primary (MCUP) is highly responsive to cisplatin-based combination chemotherapy. These therapeutic responses usually are partial and shortlived. The authors report the case of a 41-year-old man whose MCUP relapsed after responding to cisplatin, bleomycin, and etoposide. Alternate-day treatment with plicamycin induced a second complete remission (CR) in this patient with minimal hematologic and metabolic toxicity. Plicamycin may prove effective in enhancing CR rate, prolonging CR duration, and salvaging cisplatin failures in MCUP.

Adult↗
PubMed1989

Angiolipoma of the tongue: report of a case.

Angiolipoma is a rare variety of lipoma in the maxillofacial region. Only eight cases have been documented so far. A case in which an angiolipoma occurred within the tongue of a 49-year-old man is described here. The difference from earlier cases occurring in the tongue is noted. Close follow-up has, as yet, revealed no recurrence.

Hemangioma↗
PubMed1988

A t (11;21) (13;q22) in Ph-positive chronic myelogenous leukemia.

Reciprocal translocations, in addition to that of the Ph chromosome, though rare, have been reported in chronic myelogenous leukemia (CML). We describe here a case of Ph-positive CML with a new translocation, t (11;21) (q13;q22), and missing Y, which were present both during transformation to the blastic crisis and in the subsequent reversion to the chronic phase. The possible significance of this abnormality is discussed.

Aged↗