The influence of contrast medium (20 ml Meglumine Diatrizoate 65%; Angiografin) on peripheral circulation was studied after injection into the vena saphena magna in 12 patients (mean age 40.5 years) with markedly varicose veins. Pneumatic segment-plethysmography and "mercury-in-rubber" strain-gauge-plethysmography were used to investigate local and systemic effects of contrast medium on intravascular basic volume and pressure-dependent venous capacity. Heart rate was controlled by Ecg-monitoring, venous blood pressure by means of a Schwarzer pressure transducer, and peripheral blood flow by means of pneumatic segment-plethysmography. In addition peripheral vascular resistance was calculated. Local effect of contrast medium on large veins was a small insignificant increase (2.2%) of venous capacity. However, there was a significant increase of additional 10% after recirculation (2 P less than 0.01). Intravascular basic volume showed a significant increase as well (2 P less than 0.01). In addition the calculated increase of total intravascular volume--represented by intravascular basic volume plus venous capacity--was 16.3% related to an intravenous pressure of 70 mm Hg. According to these findings, 20 ml contrast medium enlarges the blood volume dumping into the legs with postural changes by approximately 270 ml. Arterial inflow increased significantly (2P less than 0.01) by 40% after contrast injection, whereas mean arterial blood pressure decreased simultaneously. Consequently a reduction of peripheral vascular resistance of 32% was calculated. The neglectable local effect of contrast medium on pressure-dependent venous capacity is probably due to the markedly reduced distensibility of varicose veins. In contrast a striking effect of contrast medium is observed after recirculation, which is felt to be due to a general vasodilatation of capillary vessels and pre- and postcapillary resistance vessels.

Adult↗

PubMedDate not supplied

[The mechanisms of the sclerotherapy of varices. Hemostatic, isotopic and histologic studies].

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Blood Coagulation↗

PubMedDate not supplied

[Study of the sclerosing of varicose veins: comparison between natural fibrinolysis in the blood of the cubital vein and the labeled fibrinogen test in the sclerosed leg].

After intravaricose injection of 3% ethoxysclerol a slight hyperfibrinolysis appears in the blood of a cubital vein. This is too weak to judge of the reality of the sclerosis. On the other hand, a very marked fibrinolysis is not seen after injection of ethoxysclerol. Fibrinogen labelled with iodine 131 however permits an exact control of what is happening at the site of the sclerosant injection. The reaction develops slowly, reaching its maximum not until 5 days after the injection of sclerosant. There is therefore no need to fear a sudden thrombosis which might be difficult to control.

Adult↗