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Biomedical subjects

T Wiznitzer

Publications and source records attributed to T Wiznitzer.

At least 37 records · Page 2Linked to original sources
PubMed1986

Recurrent spontaneous perforation of the colon.

A 58-year-old man with recurrent spontaneous perforations of the colon is reported. The first two events were of the sigmoid colon, and a sigmoidectomy was performed after the second perforation. The third spontaneous perforation had occurred in the transverse colon, however, although a patent sigmoid colostomy was present. Neither primary colonic pathology nor elevated intraluminal pressure were found, which means that the cause and pathogenesis of these perforations are unknown. Six months later, a subtotal colectomy with ileo-sigmoid anastomosis was performed with an apparent satisfactory result.

Colonic Diseases↗
PubMed1984

Lipase turbidimetric assay and acute pancreatitis.

The simplified turbidimetric assay for lipase activity was used for the differential diagnosis of acute pancreatitis. Serum lipase levels were found to be increased in a group of 17 patients in whom acute pancreatitis was clinically suspected and confirmed by a high ACCR and decreased uptake of the radionuclide in the pancreas scan. The lipase levels were within normal limits in a control group of 14 patients suffering from diseases other than acute pancreatitis. The turbidimetric test was helpful for rapid quantitative determination of serum lipase and thus for the early and accurate diagnosis of acute pancreatitis.

Acute Disease↗
PubMed1982

Hemisplenectomy using a hand-held CO2 laser. An experimental study.

Hemisplenectomy was performed in mongrel dogs using a hand held CO2 laser. Cutting and hemostasis were performed by a laser beam with a high concentration power--about 6kW/mm2--at the focal spot, and residual bleeding was controlled by using a defocused beam. The cutting action was improved by temporary closing of the arterial vessels and by injecting adrenaline into the splenic artery to produce a relatively dry surface. The surgical procedure was free of mortality or morbidity. Histological studies revealed a brand of fibrous tissue at the cut surface, without apparent abnormalities in the splenic parenchyma beneath the section. Activity of the residual half spleen was shown by postoperative technetium scan and by the fact that Howell-Jolly bodies appeared in peripheral blood only after resection of the remaining half spleen.

Animals↗
PubMed1982

Growth hormone response to L-dopa in the thinned obese.

The response of plasma growth hormone (GH) to 0.5 g L-dopa was studied in 17 obese nondiabetic subjects and in 6 normal-weight subjects, aged 16 to 46 yr. The test was repeated after the obese subjects were thinned 12 to 50 kg, either with a hypocaloric diet or by a jejunoileal shunt. All the obese subjects had a blunted response to L-dopa stimulation. Nine of the thinned obese continued to exhibit the same blunted GH response, while the other eight responded with a significant GH rise after L-dopa stimulation, although the increase was smaller than that in the controls. No correlation between the initial or final weight or the extent of weight loss and the response to L-dopa was observed. It is assumed that a hypothalamic underresponsiveness is responsible for the blunted response in the obese subjects and its persistence in some of the thinned obese.

Adolescent↗
PubMed1981

Postsplenectomy splenic activity.

Evidence of recurring activity of splenic tissue was investigated in patients who had undergone splenectomies. Methods included technetium 99m sulfur colloid scan, serum tuftsin assay, serum immunoglobulin concentration, blood cell counts, and search for Howell-Jolly bodies. Positive scans were observed together with normal levels of tuftsin in 54% of the patients. In 46% of the patients, no splenic activity was detected by scanning and low levels of tuftsin were noticed. The difference in tuftsin levels between the two groups was statistically significant. Howell-Jolly bodies and decreased serum levels of IgM featured all patients. The possible application of combined splenic scan and tuftsin assessment for screening recurring splenic activity in the postsplenectomy population at great risk is suggested.

Adolescent↗
PubMed1981

Retrograde urography with a new antiseptic contrast contrast material. An experimental study.

A new antiseptic contrast material, composed of sodium diatrizoate-meglumine diatrizoate and PVP-iodine solution, was prepared and tested for retrograde cystography. It was tested in vitro and in dogs, showed satisfactory radiological features and rapid wide bactericidal action without detectable side effects. Septic complications following radiological demonstration of the urinary tract may be reduced.

Animals↗
PubMed1981

Zinc deficiency during intravenous hyperalimentation.

Two cases of patients developing symptoms and signs of zinc deficiency while on total parenteral nutrition are presented. Supporting causes for the appearance of early low serum zinc levels are discussed. These cases serve to further stress the need of adding trace elements to solutions given to patients on long-term total parenteral nutrition.

Adult↗
PubMed1980

Experimental acute pancreatitis. Inducement by taurocholate sodium-trypsin injection into a temporarily closed duodenal loop in the rat.

Experimental pancreatitis induced by permanently closed duodenal loop results in death of the experimental animal. Acute pancreatitis can be induced in the rat by injection of taurocholate sodium-trypsin solution intraluminally into a temporarily occluded duodenal loop. Mortality in this model was 45% within one week after injection. Mean serum amylase level was greatly increased above that in control rats that underwent temporary duodenal ligation without intraduodenal injection of fluid. The presence of pancreatitis was confirmed by histological examination. The advantage of the temporarily occluded pancreatitis model is that the animal can survive if the stimulus is not excessively severe.

Acute Disease↗
PubMed1980

Partial distal pancreatectomy with a hand-held CO2 laser. An experimental study.

Partial distal pancreatectomy was performed in dogs with CO2 laser. Results were compared with those obtained with use of diathermy and scalpel. Postoperative hyperamylasemia appeared in all the animals. The highest peaks in the laser and scalpel groups were found on the fifth postoperative day, after which they gradually returned to normal; the highest levels appeared in the diathermy group on the 21st day, and returned to normal only after 56 days. Pancreatography showed a sealed duct in the laser and diathermy groups although no duct ligation was performed. Histological study of the laser group disclosed initial thermal injury at the cut section with no damage to the nearby parenchyma, followed later by a smooth, thin scar. In the diathermy and scalpel groups, the injured zone became enlarged later by active parenchymal and interlobular inflammation in the underlying tissue.

Amylases↗