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Biomedical subjects

T Witte

Publications and source records attributed to T Witte.

42 records · Page 3Linked to original sources
PubMed1992

[Fc gamma receptors: structure, function, and clinical significance].

Fc gamma receptors are a group of three different receptors with several subtypes. They are widely distributed on many cells of the immune system and contribute to the pathogenesis of immune complex- and autoantibody-mediated diseases such as vasculitis, rheumatoid arthritis, idiopathic thrombocytopenic purpura or autoimmune neutropenia. This review focuses on the structure, distribution and function in Fc gamma receptors and their subtypes.

Antigen-Antibody Complex↗
PubMed1990

A subset of CD16-natural killer cells without antibody-dependent cellular cytotoxicity function.

The low affinity IgG receptor, CD16 (Fc gamma RIII), is expressed on almost all peripheral blood natural killer (NK) cells. A small subset of CD3- CD16- CD56+ NK cells, representing less than 1% of peripheral blood lymphocytes, expands during in vivo IL-2 treatment. To analyze this CD16- NK cell subset in more detail, NK clones have been generated. One of them (TNK2) has been used to study the function of these cells in more detail. It is demonstrated that TNK2 exerts normal NK activity and displays large granular lymphocyte morphology. Since this clone lacks CD16 expression, antibody-dependent cellular cytotoxicity cannot be exerted. CD16 monoclonal antibodies fail to induce cytotoxic activity against NK-resistant target cells. These studies reveal that the lack of CD16 detection is not due to the modulation or the stage of activation of these NK cells. TNK2 is representative of this small subset of peripheral blood NK cells, expanded during IL-2 treatment, which does not express Fc gamma RIII and therefore cannot perform antibody-dependent cellular cytotoxicity.

Antibodies, Monoclonal↗
PubMed1990

Heterogeneity of human natural killer cells in the spleen.

Natural killer cells have an important role in tumour and viral defence and immunoregulation. In the present study the pan-NK cell monoclonal antibody NKH1 was utilized to study the heterogeneity of NK cells in the human spleen. Using one and two colour analysis it could be demonstrated that the majority of NKH1+ NK cells are located in the red pulp and marginal zone whereas only a minor subset is found in the lymph follicles. In the red pulp, NK cells resemble those of peripheral blood in terms of function and phenotype. In contrast, the few NK cells in the lymph follicles are mostly NKH1+, CD2- and CD16- and thus express a unique phenotype. The analysis of tissue distribution provides a basis for further studies on NK cell kinetics and differentiation.

Antibodies, Monoclonal↗
PubMed1989

[Heterogeneity of natural killer (NK) cells in the human spleen].

Natural killer (NK) cells in the human spleen represent a population of 25% of splenic lymphocytes. They are mainly located in the red pulp. In this compartment they resemble blood NK-cells in function and phenotype. Within the lymph follicles only a small subset is detected, expressing a particular phenotype.

Antibodies, Monoclonal↗