U.S. health care is missing a link between the financial managers and clinical health managers of defined patient populations. Utilization and cost management try to bridge the gap by focusing on restricted access to care or tightly managed provider reimbursement to control costs. But frequently, they do not take clinical outcomes or health status into consideration. Take a look at another method based on the science of epidemiology that brings a more balanced knowledge of the clinical world to financial managers and more financial insight to clinicians.

Community Health Planning↗

PubMedDate not supplied

Time-varying effects in mice and rats of several synthetic ACTH preparations.

Circadian stage-dependent effects characterize synthetic ACTH 1-17 preparation (HOE 433 = Synchrodyn 1-17), tested in mice and rats, with reference notably to corticosterone and aldosterone production in vitro and to the behavior of rhythms in these two corticoids as an aspect of the adrenal cortical pacemaker of the circadian system. The possibility to advance or delay the rhythm in serum corticosterone by ACTH 1-17 also is demonstrated, as is a differential behavior of the circadian rhythm in serum aldosterone. Differences in timing of circadian corticosterone and aldosterone responses also are described and await further scrutiny for ultradian and infradian (notably circannual) modulation.

Adrenocorticotropic Hormone↗

PubMedDate not supplied

Circadian-stage-specified effects of a synthetic short chain ACTH-1-17 (HOE 433) on blood leukocytes and corticosterone secretion in mice.

A synthetic short chain ACTH, ACTH-1-17 (HOE 433 = Synchrodyn 1-17), beta-ala1, lys17 corticotropin (1-17)heptadecapeptide-4-N-butylamide, was tested for activity at the anticipated circadian stage of highest adrenal corticosterone responsiveness (22-HALO) in BALB/c mice. Statistically significant dose-response relations were demonstrated both in vitro (corticosterone production by adrenals incubated in Krebs-Ringer solution) and in vivo (increases in the serum corticosterone concentration). Leukocyte counts in mice injected with this ACTH showed statistically significant decreases (as compared to controls) for all kinds of cells except the neutrophil and medium-sized lymphocyte.

Adrenocorticotropic Hormone↗

PubMedDate not supplied

A Canadian snow-shoeing in London.

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Cholera↗