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Biomedical subjects

T Wheeler

Publications and source records attributed to T Wheeler.

At least 37 records · Page 2Linked to original sources
PubMed1998

A longitudinal study of maternal serum vascular endothelial growth factor in early pregnancy.

Using a competitive radioimmunoassay to measure total immunoreactive vascular endothelial growth factor (VEGF), we describe for the first time longitudinal changes in serum VEGF in early pregnancy. The measurements were obtained from 26 women following the transfer of cryopreserved embryos; 18 singleton and eight twin pregnancies were identified by ultrasound at 6 weeks gestation and subsequently delivered as live births. Subjects did not have corpora lutea and exogenous hormone support was provided for the first 70 days of pregnancy. Serum VEGF increased approximately 30 days after embryo transfer and thereafter continued to rise in both singleton and twin pregnancies over a period of 20-40 days after which concentrations remained elevated. The longitudinal profile of serum VEGF concentrations was characterized by a logistic curve for singleton and twin pregnancies; the profile of VEGF concentrations in the twin pregnancies was significantly higher than in the singleton pregnancies (P < 0.0001). Profiles of the longitudinal concentrations of serum human chorionic gonadotrophin (HCG), oestradiol and progesterone were created by polynomial regression for singleton and twin pregnancies. The VEGF profiles were positively correlated with the profiles of HCG (r = 0.44, P = 0.02) and oestradiol (r = 0.36, P = 0.07) but not progesterone (r = 0.16, P = 0.42). Serum VEGF concentrations in the singleton thawed embryo pregnancies were compared with gestation-matched normal singleton pregnancies with corpora lutea. Concentrations of VEGF were significantly (P = 0.004) greater in the pregnancies with corpora lutea although this difference became less marked with advancing gestation. In addition to its important role in angiogenesis, we speculate that VEGF is involved in mechanisms which control the maternal cardiovascular adaptation to pregnancy.

Chorionic Gonadotropin↗
PubMed1998

Disproportionate fetal growth and fingerprint patterns.

Fingerprint whorl patterns are formed during fetal life. In a group of 180 term infants, those with more fingerprint whorls tended to have a small abdominal circumference (P = 0.09) and high ratio of head to abdominal circumference (P = 0.008). These associations were independent of the relation between the whorl counts of the mothers and their infants. We also found an independent correlation between the babies' whorl count and the combination of increasing subscapular (P = 0.03) and decreasing triceps (P = 0.02) skinfold thicknesses of the mothers. Whorl patterns are associated with adult hypertension; maternal nutritional status may influence their common origin during fetal development.

Adult↗
PubMed1998

Attitudes and compliance of pre-adolescent children during early treatment of Class II malocclusion.

A survey was administered to 168 parents and their children at the end of mixed dentition treatment for Class II correction utilizing bionators and headgears to investigate attitudes of parents and patients toward bionators and headgears and to elicit factors associated with compliance. Directional differences between parent and child responses occurred frequently with agreement ranging from 41 to 100%, averaging 69% overall. The results indicate that the orthodontic patient population has medical and dental health as a priority. While parental and child reasons for seeking treatment may be different, it appears that both groups seek care for perceived benefits of health, decreased present and future oral problems, peer influences, and dental self image improvement. Additionally, children who are undergoing treatment perceive that others do not understand what they are going through, they may be embarrassed, and some may break their appliances to annoy the parent or orthodontist. Pain, decreased ability to speak, and difficulty chewing were reported to decrease appliance wear. Patient understanding of the treatment goals was reported to increase compliance. The bionator caused more instances of speech problems and associated non-compliance than the headgear. The headgear caused more instances of pain, but did not cause significantly less associated compliance than the bionator. The results suggest that bolstering the patient-orthodontist relationship, informing the patient about the treatment goals, methods, and their individual role, and offering immediate short term rewards can potentially increase patient compliance.

Activator Appliances↗
PubMed1998

Empirically supported psychosocial treatments for attention deficit hyperactivity disorder.

Reviews and evaluates psychosocial treatments for attention deficit hyperactivity disorder (ADHD) in children and adolescents according to Task Force Criteria (Lonigan, Elbert, & Johnson, this issue). It is concluded that behavioral parent training and behavioral interventions in the classroom meet criteria for well-established treatments. Cognitive interventions do not meet criteria for well-established or probably efficacious treatments. Issues regarding the evaluative process are discussed and future directions for psychosocial treatment for ADHD are outlined.

Adolescent↗
PubMed1998

Strategies for delivering tele-home care--provider profiles.

Tele-home health care is expanding, and it is easy to say why. There are about 1.5 million home health visits each day in the U.S. For the substantial fraction of these that are staffed by a Registered Nurse, the average cost/visit is nearly $90. Several small studies have shown that the cost per visit for a tele-home visit is about $20-$30--that is, one third, or less, the price of an onsite visit. This is due, of course, to the substantial overhead in an on-site visit: the automobile and the time spent driving and parking. The same nurse that can visit only 5 or 6 patients in their homes each day can see 15-25 patients daily using telenursing technology. Increasingly, this efficiency is starting to compel the attention of strategic planners in healthcare. Tele-home nursing uses a variety of video and telemonitoring technologies. These can be configured to connect the patient to a nursing call center or to a specific practitioner. In the past we've reviewed tele-home nursing and call-center services extensively, most recently in our December 1997 issue. With this story we take a close look at individual companies and the way they are integrating new technologies into service-delivery programs.

Chronic Disease↗