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T Weinert

Publications and source records attributed to T Weinert.

22 records · Page 2Linked to original sources
PubMed1989

Control of G2 delay by the rad9 gene of Saccharomyces cerevisiae.

In response to DNA damage, Saccharomyces cerevisiae cells arrest the cell cycle in the G2 phase. Arrest is defective in rad9 mutants; rad9 cells divide and die without repairing the damage. Several cell cycle mutants that are defective in DNA replication arrest in G2 at the restrictive temperature; this arrest is due to the RAD9 control function. Thus RAD9 is responsible for the fact that mitosis is normally dependent upon DNA replication, a function we term a 'checkpoint'. Four additional genes have been identified that are also components of the RAD9 checkpoint.

DNA Damage↗
PubMed1983

[Fees and compensation for therapy in foreign populations. A contribution to medical ethics from the history of medicine and ethnomedical point of view].

The 'Human Relations Area Files' (Yale) have been looked through in respect of the medical data on 220 peoples, tribes or ethnic groups. Concerning our theme data for 162 ethnies (73.6%) were available. In 26 ethnies of 162 ethnies (16%) no compensation has been demanded but in 11 ethnies gifts were accepted. Only 15 ethnies or less than 1/10 do not know any compensation for therapy. Payment is mentioned with 144 ethnies (89%). This outspoken opinion of the Ojibwa near the great lakes of Canada is widespread in the world: "You can't have anything for nothing". (1932) In 55 ethnies (34%) a 'very high' fee was paid, with another 47 ethnies (29%) a 'fair' fee was paid, this is altogether about 2/3. In 21 ethnies (13%) only a 'small' fee was paid. With another 30 ethnies (19%) the compensation could not be rated. In 43 ethnies (27%) a fee was paid only in case of success, this is more than 1/4. 12 times deposits are reported, this is especially common in central and southern Africa. 4 times refusal of payment is reported. Recourse (Regress) was positively absent in 9 ethnies but reported with 39 ethnies, this is 1/4 (24%). In 24 ethnies (15%) the recourse turns out sometimes or mostly with the death of the therapist, this is 1/6. This deadly recourse is obviously more common in the New World. Simple recourse or recourse with strokes were reported with 25 ethnies (15%). Because mortal and non-mortal recourses were reported twice with 10 ethnies the total of recourses is 39. Recourse does not depend on any fee at all. In the Middle East and in islamic Africa fees in general are small. There is a tendency towards very high fees in the less civilized ethnic groups. Typical in this respect is an observation in the bushnegroes of Guayana in Latin-America, where with free medical aid the reputation of the (white) doctor dwindles to the mind of everyone (1948).

Africa↗
PubMed1982

Potent microtubule inhibitor protein from Dictyostelium discoideum.

A novel potent protein factor capable of inhibiting the in vitro polymerization of mammalian brain microtubule protein and of breaking down preformed microtubules has been partially purified from cell extracts of Dictyostelium discoideum. The factor has an apparent Mr of around 13000 and is trypsin resistant but heat and pepsin sensitive. When soluble microtubule protein was fractionated into tubulin and microtubule-associated proteins and each fraction was assayed independently for its susceptibility toward inhibition, it was clearly demonstrated that the tubulin but not the associated protein fraction was rendered nonpolymerizable. Soluble tubulin was inactivated at ratios of 1 mol of inhibitor to 100 mol of tubulin, estimated conservatively. Quantitative separation of tubulin and inhibitor after inactivation did not result in reactivation of tubulin's polymerizing capacity, suggesting a catalytic modification. The biochemical properties tested of the inactive tubulin argue against a mechanism involving simple proteolysis, N-site GTP hydrolysis or release, or general denaturation.

Animals↗