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T Weber

Publications and source records attributed to T Weber.

At least 361 records · Page 20Linked to original sources
PubMed1987

Differential transcription of the repetitive R-element in various mouse cell types.

Clones that contain R-elements separated from the rest of the L1-repeat have been isolated from a mouse genomic DNA library. Spot hybridization of DNA from various species (from mammals to plants) with one representative and well characterized mouse DNA clone shows that at least this sequence hybridizes only with mouse DNA. In addition, we demonstrate that the R-element repeat is transcribed differentially in various tissues or cell types. Furthermore, the amount of R-transcripts is regulated at varying rates in the different cell types of a tissue as shown by in situ hybridization.

Animals↗
PubMed1987

Suction fixation of the tcPco2 electrode for fetal monitoring.

The fixation ring for suction fixation is made of a soft plastic material and is measuring 24.5 mm in diameter and 5.8 mm in height. The electrode is mounted into the center of the ring and kept in position by the elasticity of the material. A polyethylene catheter is glued into the ring connecting it to the vacuum pump (-20 kPa). The soft plastic material will be deformed by heating, and sterilization should be performed by gamma radiation or by fluid aldehydes. The electrode mounted in the suction ring is attached to the fetal head during vaginal examination without amnioscopy or the use of application tools. The suction fixation technique was evaluated in relation to the glue fixation technique by simultaneous measurements with two electrodes. In adult monitoring no differences in stabilization times and Pco2 values were found. In fetal monitoring a little difference (0.3 kPa) in mean values was found at a cervical dilatation of less than 8 cm, but no difference was found at a cervical dilatation of more than 8 cm. Calibration may be performed by either two-point or one-point calibration. One-point calibration is usually sufficient, but the sensitivity of the electrode should be checked regularly. Electrode sterilization by fluid aldehydes following the calibration does not influence electrode drift. A close correlation was found between the transcutaneous carbon dioxide tension just before delivery and the Pco2 of umbilical artery blood (r = 0.77, n = 64). Stabilization time was short (2.1 min.) and the electrode drift usually low (mean -0.14 kPa or 2.7%) independent of the duration of the monitoring.(ABSTRACT TRUNCATED AT 250 WORDS)

Blood Gas Monitoring, Transcutaneous↗
PubMed1987

Light microscopical morphometry, immunocytochemistry, and clinical correlations of pituitary adenomas at various stages of oncocytic transformation.

In a series of 124 pituitary adenomas displaying oncocytic alterations, we studied the degree of oncocytic transformation by light microcopical and morphometrical means for semiquantitative analysis. We established three groups with different percentages of oncocytically transformed cells for comparison of clinical and immunocytochemical data. Of the patients, 32.3% exposed adenomas with less than 50% oncocytic alterations (group I), whereas 22.6% showed tumours with oncocytic transformations between 51% and 75% (group II). Oncocytic parts consisting of more than 75% of the tumour cells were found in 41.1% of the patients (group III). All three groups differed in the rate of immunocytochemically positive cases, but not in sex distribution, tumour size, and rate of recurrency. Immunocytochemical analyses for PRL and GH (81 vs 78 adenomas) showed a decline of immunohistochemically positive adenomas with increasing proportions of oncocytic transformation for both hormones. Whereas in group I 38% of the adenomas were PRL-positive and 15% GH-positive, group III displayed only 9% PRL-positive and 3% GH-positive adenomas. The results display the correlation between the increasing volume of oncocytic transformation and its effect on decreasing hormone content in pituitary adenomas.

Adenoma↗
PubMed1987

Outpatient treatment of cervical intra-epithelial neoplasia. The CO2 laser versus cryotherapy, a randomized trial.

In a randomized study, 204 patients were allocated to either laser or cryo treatment for cervical intra-epithelial neoplasia (CIN). The patients were treated on an outpatient basis without anesthesia unless other conditions requiring anesthesia had to be dealt with at the same time. Both the laser and the cryo method were highly acceptable to the patients. Slightly more patients experienced moderate or severe pain during laser treatment, compared with cryo treatment (P = 0.05). Peroperative hemorrhage did not exceed 25 cc except for one laser-treated patient. Postoperative vaginal discharge was more often seen after cryo coagulation, the discharge being malodorous in 36% of cryo-treated patients and in 17% of laser-treated patients. Pelvic inflammatory disease was found in one patient in each treatment group. Postoperative spotting occurred more often in laser-treated patients (49%) than in cryo-treated patients (22%). At follow-up colposcopy 3 months after treatment, the squamocolumnar junction was fully visible significantly more often in laser-treated patients (P less than 0.001). The cure rates after one laser or cryo treatment were 90% and 91%, respectively. Subsequent to 19 initial treatment failures, 8 patients have at present been retreated with the same method as initially used, and all 8 are cured. The cure rates after one or two treatments are 96% in the laser group and 93% in the cryo group. The rates are preliminary, due to the short observation time. Publications will appear when all patients have been followed for 2 and 5 years.

Adult↗
PubMed1987

Double-blind study on antitissue immunoglobulin injections versus placebo in the treatment of acute lumbar pain with muscular spasms.

A double-blind study was carried out on antitissue immunoglobulins (Sérocytol Neuro-Vasculaire) administered by intradermal injections to 44 patients (24 women, 20 men; age range 36-76 years) suffering from acute lumbar pain accompanied by muscular spasms. In the treated group of 21 patients, excellent or good results were recorded in 14 cases (67%) and moderate results or no effect in 7 (33%). The mean number of injections necessary was 3.7 per patient. Injections were given every four days. In the placebo group of 20 patients (an addition 3 having dropped out), excellent or good results were obtained in 6 cases (30%) and moderate results or no effect in 14 (70%). The mean number of injections required was 4.6 per patient. The parameters considered included pain (night wakings, spontaneous pain and pain on pressure) and mobility (Schober's index, distance from fingertips to ground, extension, lateroflexion). The investigating physician's evaluation of the efficacy of antitissue immunoglobulins was similar to that of the patients. Tolerance of the product was excellent in all cases.

Acute Disease↗
PubMed1986

Sodium homeostasis in infants with biliary drainage procedures.

We studied biliary excretion of sodium and chloride in 17 infants with external bile drainage through a "biliostomy" and describe four additional children who became ill from sodium depletion following external biliary drainage procedures for biliary tract anomalies. In the 17 infants, the mean +/- SD bile sodium concentration was 122 +/- 15 mEq/L. The mean +/- SD serum sodium concentration was low (132 +/- 7 mEq/L) (normal, 138 to 145 mEq/L). The mean +/- SD bile volume was 388 +/- 317 mL/day at one year following surgery (range, 40 to 1,000 mL/day). In the four children, clinical manifestations of sodium depletion (lethargy, anorexia, dehydration, and malnutrition) necessitated hospital admission. At that time, the serum sodium concentration ranged from 109 to 129 mEq/L, and the simultaneous urinary sodium concentration ranged from 0 to 5 mEq/L. Although dietary sodium was normal, biliary losses exceeded dietary intake, resulting in salt and water depletion despite renal conservation. Children with biliary drainage procedures are at risk for sodium depletion and should be monitored closely and supplemented accordingly until biliostomy closure is performed.

Bile↗
PubMed1986

Continuous standard base excess monitoring during human labour.

Previously, the various components of fetal acid-base state during labour could only be estimated discontinuously by fetal blood sampling, or continuously by monitoring of a single component. This is the first report describing simultaneous continuous monitoring of the tissue pH, the transcutaneous carbon dioxide tension and on-line calculation of the tissue-standard base excess (t-SBE) of the human fetus during labour. In seven uncomplicated deliveries t-SBE was increasing or constant, thus indicating no fetal hypoxia. When a more reliable tissue pH electrode becomes available, t-SBE calculation may become a valuable tool in the management of high-risk labours.

Acidosis↗
PubMed1986

Fetal carbon dioxide tension during human labour.

Fetal carbon dioxide tension during labour is elevated in both metabolic and respiratory acidosis, but intermittent fetal blood analyses often fail to detect PCO2 changes during acute complications. Transcutaneous carbon dioxide monitoring is continuous and the possibility of diagnosing PCO2 changes is therefore better. The theoretical background for transcutaneous measurements and methods for clinical monitoring are described. Close correlations with capillary and arterial blood values have been found, and the atraumatic principle with a simple electrode application indicates a promising new method for acid-base assessment during human labour.

Acidosis↗
PubMed1986

Fetal transcutaneous carbon dioxide monitoring--the effect of different fixation methods.

Fetal transcutaneous carbon dioxide tension (tc-Pco2) was monitored simultaneously by two electrodes fixed with glue or suction during 10 deliveries. There were no differences in success rate, tc-Pco2 readings or stabilization time between the two fixation methods, but the glue fixation method was more time consuming, caused more discomfort to the patient and generally did not permit reapplication of the electrode.

Blood Gas Monitoring, Transcutaneous↗
PubMed1986

The effect of electrode compression during fetal transcutaneous carbon dioxide monitoring.

The influence of electrode compression by the cervix on transcutaneous CO2 measurements (tc-Pco2) was studied during 20 deliveries by simultaneous measurements with two electrodes, one positioned under the cervical edge and the other free of the cervix. At a cervical dilation of less than 8 cm, significantly higher values were measured by the electrode exposed to cervical compression, and tc-Pco2 fluctuations with uterine contractions were observed. This study confirms that the tonsure effect usually does not interfere with tc-Pco2 monitoring.

Blood Gas Monitoring, Transcutaneous↗
PubMed1986

Pregnancy following kidney transplantation.

Following kidney transplantation, 20 women gave birth to 24 infants after the 28th gestational week. All babies were singletons, alive, and free from malformations. The mean weight was 2,595 g (range 1,420-3,200 g) and the mean gestational age was 37.8 weeks (range 32-40 weeks). The cesarean section rate was 75%. On dividing the patients into low- and high-risk groups, the rate of pre-eclampsia, prematurity, and intra-uterine growth retardation was 2-3 times as high in the high-risk as in the low-risk group. No patients experienced graft rejection during the pregnancy but, within 3 months after delivery, two rejection episodes occurred. Later, a further 5 patients experienced graft rejection. All infants developed normally. We conclude that pregnancy following renal transplantation generally has a normal outcome and that the function of the transplanted kidney is unaffected by the pregnancy.

Adult↗