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Biomedical subjects

T Watanuki

Publications and source records attributed to T Watanuki.

At least 37 records · Page 2Linked to original sources
PubMed1983

Malignant lymphoma of the large intestine--operative results in Japan.

One hundred thirty cases of primary malignant lymphoma of the large intestine in Japan were studied with regard to operative results. The averaged age was 52.6 years and most of the patients were men. Sites of the tumor were the cecum (71.5 per cent), rectum (16.9 per cent) and the ascending colon (6.2 per cent). Surgery was performed for 129 (99.2 per cent) of the 130, of which 71 (55 per cent) were curatively resected. Surgical procedures were mostly Miles operation and the others were anterior resections and hemicolectomies. Postoperative 5 and 10 year survival rates were 34.8 per cent and 33.2 per cent respectively, and the rates after curative resection were 44.2 per cent and 40 per cent respectively. Prognoses were better when the tumor was of 5 cm or less in diameter, intraluminal and without lymph node metastasis. Classified histologically, most of the tumors were of histiocytic type, followed by lymphocytic, mixed type and Hodgkin's disease. Five and ten year survival rates of the curative resection group, by histological type, were both 38.9 per cent for histiocytic type, both 43 per cent for lymphocytic type, 43.8 per cent and 21.9 per cent respectively for mixed type, and both 100 per cent for Hodgkin's disease. Therefore, the operative result of malignant lymphoma in the large intestine was poor compared with results in case of cancer of the large intestine.

Adolescent↗
PubMed1980

[Toxicological studies on dibekacin for intravenous injection use. I. Subacute toxicity in rats and rabbits (author's transl)].

Dibekacin sulfate (DKB) dissolved in physiological saline J.P. was administered to rats intraperitoneally and rabbits intravenously for subacute 35-day toxicity test. The results were as follows: I. Wistar-strain rats (1) All the animals of both male and female died in the group with 500 mg/kg. (2) In general conditions stretching physical positions, decrease in spontaneous movements, decrease in respiration rates, unsteady steps of walking and muscular relaxation developed in the groups of high doses of either sex. The effects through the administration of this drug were also noted on the progress of body weights and food intakes in the groups of high doses. (3) In the hematological and histopathological studies, degenerative and reparative changes of tubular epithelia were evidently noted in the groups which were administered more than 100 mg/kg of DKB in both male and female. No pathological findings were noted in administration groups less than 20 mg/kg. (4) Microscopically, slight inflammatory changes were noted in the bladder of the male groups of high doses and the direct stimulative effects on the peritoneum due to intraperitoneal administration were noted but slightly in the serous membrane of the liver, spleen and the gastrointestinal tracts. (5) Judging from the above-mentioned results, "the maximal non toxic dose" through the intraperitoneal administration to rats of this drug was assumed 20 mg/kg in either sex. II. Albino rabbits (1) Neither remarkable change in the general conditions nor death was noted in each administration group. (2) The increase in the mean body weight in each group was almost similar to the control value. They consumed the amounts of food given. (3) The specific abnormal finding was not noted in the hematology and biochemical tests of serum or urine. (4) Since no change was noted on ERG in each rabbits, we estimate there is no effect to the visual organs. (5) In histopathological study, several changes revealed in some organs through the macroscopic findings, organ weights and microscopic findings but they were no more the serious changes attributable to administration. (6) We estimate "the maximal non effective dose" in this test was 10 mg/kg.

Animals↗
PubMed1980

[Toxicological studies on dibekacin for intravenous injection use. II. Chronic toxicity in rats (author's transl)].

The toxic effects of dibekacin sulfate (DKB) in male and female rats were examined in chronic toxicity test (intraperitoneal injection), and the following results were obtained. 1) No death was noted in both male and female. 2) In general conditions, the excretion of soft or diarrheal stool was noted in groups of more than 20 mg/kg of either sex. The mean body weight was less than the control during a certain period in the male group of 40 mg/kg and in the female group of 20 mg/kg. But, in the food intakes, no particular change was noted in each group of either sex. 3) In the auricle reflex, no abnormality was noted in each group of either sex. 4) In the hematological test, the findings such as an increase of BUN, anemia, etc. were noted in the groups more than 10 mg/kg of male and more than 20 mg/kg of female. 5) In the histopathological study, evident degenerative changes of renal tubular epithelia were noted in the groups which were administered more than 20 mg/kg of DKB in both male and female, but no evident pathological findings due to the renal failure were noted in the groups of less than 10 mg/kg. Several slight changes of the thyroid gland noted in a few rats of DKB administration group of both male and female seemed to be artifact, and inflammatory changes owing to intraperitoneal injection were occasionally noted in the peritoneum of DKB injected animals. 6) Considering the above results, "the maximal non effective dose" was estimated to be 10 mg/kg in both male and female.

Animals↗
PubMed1979

Operative and postoperative choledochofiberoscopy.

Choledochofiberoscopy is effective for both diagnosis and therapy. It is a valuable diagnostic technic because it permits a definite diagnosis and it allows the surgeon to determine the operative method by direct viewing and by biopsy of the biliary tract wall. Choledochofiberoscopy is therapeutically valuable because it permits cleaning of the bile duct, the removal of retained or remnant stones in the common and intrahepatic ducts, and the removal of granuloma and benign tumor with forceps under direct vision.

Biliary Tract Surgical Procedures↗