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Biomedical subjects

T Walsh

Publications and source records attributed to T Walsh.

At least 91 records · Page 5Linked to original sources

Outpatient treatment of patients with substance abuse and coexisting psychiatric disorders.

Thirty-two patients with coexisting substance abuse and other psychiatric disorders were treated in a unique outpatient pilot program that used techniques drawn from both psychiatric and substance abuse treatment. Eleven patients remained in treatment for 3 or more months, and seven completed a year or more of treatment. Severity of associated psychiatric illness did not affect retention in treatment. Drug-abusing patients and those with personality disorders dropped out quickly; patients with a history of reliable outpatient treatment involvement tended to remain in treatment. Treatment retention was associated with reduced hospital utilization. The authors suggest guidelines for management of patients with coexisting substance abuse and other psychiatric disorders.

Adult↗

Intracranial neoplasms in children.

The outlook for children with intracranial neoplasms is not uniformly bleak. Fully half of these children have nonmalignant tumors. Treatment for patients with inoperable lesions remains unsatisfactory but may significantly prolong useful function. Knowledge of the wide variety of signs and symptoms produced by brain tumors in children, along with the increased availability of computed tomography, usually enables the physician to make the diagnosis quickly and refer the patient for treatment.

Adolescent↗

Demonstration of pancreatic parenchyma by digital subtraction techniques during endoscopic retrograde cholangiopancreatography.

This paper reports the feasibility of using digital subtraction angiography techniques during endoscopic retrograde cholangiopancreatography to obtain greater detail of pancreatic structure. The pancreatic duct was filled in 23 of 27 cases attempted and in 17 cases parenchymal detail was obtained. Filling defects due to neoplasm were clearly defined and the changes of chronic pancreatitis visualised. The technique seems valuable for small lesions but may carry a higher risk of producing pancreatitis.

Acute Disease↗

Patients with small-cell lung cancer treated with combination chemotherapy with or without irradiation. Data on potential cures, chronic toxicities, and late relapses after a five- to eleven-year follow-up.

We assessed the outcome in 252 patients with small-cell lung cancer 5 to 11 years after treatment with combination chemotherapy, with or without chest and cranial irradiation, in National Cancer Institute therapeutic trials from 1973 through 1978. Twenty-eight patients (11%) survived free of cancer for 30 months or more. Fourteen patients remain alive without evidence of cancer beyond 5 years (range, 6.4 to 11.3 years), and 7 patients have returned to a lifestyle similar to that before diagnosis. The other 14 patients who were cancer-free at 30 months have developed cancer or died; 6 patients had a relapse, 4 developed or died from non-small-cell lung cancer, and 4 died of unrelated causes. A few patients with small-cell lung cancer (5.6%) may be cured. Thirty-month, cancer-free survival is insufficient to show a cure. Although late toxicities are troublesome, they do not outweigh the benefits of prolonged survival and potential for cure with modern aggressive therapy in small-cell lung cancer.

Adult↗

Ender nailing for peritrochanteric fractures of the femur. An analysis of indications, factors related to mechanical failure, and postoperative results.

Of 100 patients with a peritrochanteric fracture of the femur treated by the Ender technique, we reviewed the cases of seventy-nine after an average follow-up of 11.4 months in order to clarify the indications for the procedure and investigate variables that may affect the results. The variables that correlated with the failure rate appeared to be the quality of the reduction, the number of nails used, the experience of the surgeon with the technique, and the degree of fracture instability. Nail placement in terms of medial-lateral and anterior-posterior positioning within the femoral head, however, did not appear to correlate. The Ender technique seems to be reasonably effective both for the treatment of stable intertrochanteric fractures and, if a good reduction and four or more nails are used, for the treatment of four-part unstable fractures. We do not recommend the technique for fractures with a subtrochanteric component unless mobilization of the patient can be delayed.

Adult↗

Voice-onset time as a clue to the nature of Broca speech errors.

Blumstein, Cooper, Goodglass, Statlender, and Gottleib (Brain and Language, 9, 153-170 (1980] attempt to determine by an examination of the VOTs of aphasic speakers whether Broca's aphasics make phonemic substitutions in addition to their well-known phonetic errors. There are a number of problems with this study, mostly due to an apparent failure to fully appreciate the fact that VOT is a cover term for several acoustic features. It is suggested that VOT measurement in any given position in a word cannot solve this problem and that future studies should include glottographic observations as well as VOT measurements made in all positions in the word.

Aphasia↗

Quality review of outpatient psychopharmacological practice with APA Task Force criteria.

The authors conducted quality review of outpatient psychopharmacological practice in 180 cases with the screening criteria of the APA Task Force on Psychopharmacological Criteria Development and a subset of 12 criteria involving higher-risk practices. Excessive duration of drug treatment was the most common questionable practice, and no relationship was found between frequency of questionable practices and patients' sex, age, social class, or Global Assessment Scale score. An educational exercise based on the audit resulted in a nonsignificant decrease in the higher-risk practices.

Adolescent↗

Late sequelae of allergic bronchopulmonary aspergillosis.

Seven patients with late sequelae of allergic bronchopulmonary aspergillosis (ABPA) are described. All seven had significant chronic symptoms from asthma. At the time of diagnosis of ABPA all patients had marked irreversible pulmonary function abnormalities; symptoms of chronic bronchitis were present in all. Pulmonary fibrosis was present in six of seven patients. Three patients have died from irreversible lung disease with terminal cardiac failure. Despite the difficulty in establishing an early diagnosis of ABPA, its importance must be emphasized in order to attempt to prevent progression of the disease to severe irreversible and potentially fatal end-stage lung disease.

Adult↗

Part-time staff.

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Dental Staff↗

The ototoxic potential of propylene glycol in guinea pigs.

Propylene glycol, previously indicated to be ototoxic and to produce "deafness," was studied in the middle ear space of guinea pigs. Ninety percent propylene glycol produced conductive middle ear problems, but there was no loss of hair cells above that found in normal untreated animals. Ten percent propylene glycol produced no negative effects in the middle ear or elsewhere. Topical ear drops containing high concentrations of propylene glycol are contraindicated in cases with perforation of the tympanic membrane.

Action Potentials↗