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Biomedical subjects

T Walley

Publications and source records attributed to T Walley.

120 records · Page 7Linked to original sources
PubMed1990

Adverse effects of captopril in hospital outpatients with hypertension.

Hypertensive patients prescribed captopril while attending a hospital hypertension clinic were studied, to identify the benefits of the drug, its adverse effects and factors predisposing to them. One hundred and eighty two patients were followed for a mean of 18 months; 24 received captopril alone, and 158 combinations of captopril and other antihypertensive drugs, especially loop diuretics (91/158), or thiazide diuretics (57/158), or other vasodilators (57/158). The mean final dose of captopril was 67 mg/day. Blood pressure (BP) was effectively controlled in 73% of patients (mean fall in systolic BP 29 mmHg, CI 24 to 34, P less than or equal to 0.001; mean fall in diastolic BP 18 mmHg, CI 16 to 20, P less than or equal to 0.001). Blood urea and creatinine rose slightly in all patients (urea by 0.9 mmol/l [13%], CI 0.5-1.3, P less than or equal to 0.001 and creatinine by 9 mumols/l [8%], CI 4-13, P less than or equal to 0.001). Twenty six patients were withdrawn from captopril therapy: 6 because of poor control of their blood pressure, two because it was no longer necessary and 12 (7.7%) because of extrarenal adverse effects--10 for rashes, one each for gastric upset and impotence. Captopril was withdrawn in a further 6 patients, because of deteriorating renal function. Factors discriminating those at risk of renal dysfunction were high doses of captopril, concomitant high dose diuretic therapy and undiagnosed renovascular disease.

Adult↗
PubMed1987

Nitrite-induced methaemoglobinaemia.

Three patients developed methaemoglobinaemia after eating meat contaminated with excessive nitrites. Diagnosis was delayed in the first two mild cases but was promptly made in the third most severely affected case.

Adolescent↗
PubMedDate not supplied

Trends in primary care antibiotic prescribing in England 1994-1998.

PURPOSE: To investigate the changing decisions to prescribe antibiotics as manifest in the patterns of prescriptions dispensed in England, and to investigate antibiotic prescribing in different types of practice. METHODS: Antibiotic prescribing data and practice characteristics collected for every practice in England for the years 1994/5-1997/8. Morbidity data for common infections was also obtained from published sources. RESULTS: Antibiotic prescribing was related to practice characteristics, with high prescribing in deprived and single-handed practices in particular. There was a fall in antibiotic prescribing in all types of practice of practice over the period of the study. Morbidity data from other sources shows a fall in diagnosed morbidity from some infectious diseases over the same period. There were no differences in choice of antibiotic in different types of practice. CONCLUSIONS: The fall in antibiotic prescribing is universal across all kinds of practices and is possibly related to the fall in diagnoses. It is uncertain whether this reflects true morbidity.

Age Factors↗
PubMedDate not supplied

Autoregulation of tissue blood flow in essential hypertension.

Autoregulation of tissue blood flow is a mechanism by which tissues control their own blood supply. The mechanism is dependent on an intrinsic capacity of tissues to vary their arteriolar resistance in relation to their needs. One view of the nature of the increased peripheral resistance in essential hypertension is that it represents autoregulatory vasoconstriction functioning to hold in check a cardiac output that would otherwise be excessive; in this situation autoregulation would be functioning normally. An alternative view is that the increased peripheral resistance represents the effect of a direct-acting vasoconstrictor substance; in this situation autoregulation would be rendered defective in its vasodilator capacity. A study of autoregulatory vasodilatation in eight subjects with essential hypertension supported an autoregulatory mechanism as the cause of the increased peripheral resistance.

Adult↗
PubMedDate not supplied

Reporting of adverse drug reactions: practice in the UK.

As the range of available drugs becomes increasingly wide, it is ever more important for adverse drug reactions and interactions to be reported. With the extended role of the nurse moving closer towards nurse prescribing, this article seeks to demystify the adverse drug reactions reporting system in the UK, and explain the role of nurses.

Adverse Drug Reaction Reporting Systems↗