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Biomedical subjects

T Wakatsuki

Publications and source records attributed to T Wakatsuki.

At least 109 records · Page 6Linked to original sources
PubMed1987

[Intrahepatic-artery infusion of cis-diamminedichloroplatinum (II) and 5-fluorouracil in primary or metastatic liver cancer].

Eight hepatocellular cancer patients and eighteen metastatic liver cancer patients were treated with intrahepato-arterial infusion of CDDP (cis-diamminedichloro-platinum II) plus 5-FU (5-fluorouracil); CDDP (0.8-1.0 mg/kg) was given once every 7 or 10-14 days, while 5-FU (250-100 mg/day) was infused daily. A partial response was obtained in 5 of 8 patients with primary liver cancer and in 9 of 14 evaluable patients with metastatic liver cancer. However, severe complications due to bone marrow suppression were observed in 4 patients, 3 of whom died of septicemia and one of enterocolitis. This combined intra-hepato-arterial chemotherapy exerts a synergistic anticancer effect on malignant liver tumors, although the bone marrow suppression associated with it remains to be overcome.

Adult↗
PubMed1986

Negative correlation between cholecystectomy and the subsequent development of large bowel carcinoma in a low-risk Japanese population.

The incidence of previous cholecystectomy in a series of 541 patients with colorectal cancer and 1832 patients with stomach cancer was studied. Five patients (0.92 percent) with colorectal cancer and eight (0.44 percent) with stomach cancer had undergone previous cholecystectomy. To avoid biases in the two groups of patients, 416 pairs of patients, comparable in sex, age, and time of admission for cancer treatment, were matched from each group to compare the number of patients who had undergone previous cholecystectomy. Within these matched pairs, three patients with colorectal cancer and two with stomach cancer had histories of cholecystectomy. Hence, no substantial difference was noted between the two groups. In a follow-up study of 461 patients who had undergone cholecystectomy for gallstones, large bowel carcinoma and stomach carcinoma developed in one and six patients, respectively, during an observation period of four to 36 years. The ratio of patients with large bowel cancer to those with stomach cancer observed in this survey was almost equal to the value estimated for the population of Tottori Prefecture, where the majority of the patients reside. The incidence of large bowel carcinoma is not increased among cholecystectomized patients in a low-risk Japanese population.

Adolescent↗
PubMed1986

[Types of surgical operations and cancer development].

Experimental and clinical studies were undertaken to examine whether carcinogenesis in particular organs is influenced by types of surgical operations resulting in an alteration of bile acid excretion and metabolism. A higher incidence of remnant gastric carcinoma was noted in rats receiving gastrectomy with a greater amount of duodenogastric reflux. Furthermore, carcinogenesis was enhanced in gastrectomized rats that had been fed on a high-cholesterol diet causing an increase in bile acid excretion. In a human study, however, there was no relationship between gastrectomy and the incidence of remnant stomach carcinoma. Intestinal surgery alters bile acid metabolism, which may promote colon carcinogenesis. In patients receiving ileocecal resection or right hemicolectomy, the amount of total fecal bile acids was markedly increased as compared to the normal controls. A retrospective study on the incidence of metachronous colorectal cancer in our department showed that the incidence was 12.2% in patients with ileocecal resection in contrast to 4.4% in those with left-side colon resection. These findings suggest that there is a relationship between previous ileocecal resection and the development of metachronous colon carcinoma. We could not obtain any evidence of cholecystectomy having an increased risk for the development of colorectal carcinoma.

Animals↗
PubMed1986

Esophageal cancer developed after gastrectomy.

Between 1965 and 1983 we treated 129 patients with primary esophageal squamous cell carcinoma. Of these patients, 12 (9.3%) had previously undergone partial gastrectomy and six manifested tumors in the lower thoracic esophagus. Esophagitis of the noncancerous esophageal mucosa surrounding the cancer was confirmed in three of five patients who underwent esophagectomy. We also retrospectively evaluated 130 patients with esophageal cancer who had undergone gastrectomy, including our 12 patients, reported in the Japanese literature between the same period. Between patients with esophageal cancer who had undergone gastrectomy and those who had not there was no age difference; there were more men in the first group. Cancer developed in the lower thoracic esophagus with relatively high frequency in patients who had undergone gastrectomy compared with those who had not. The possibility of an association between gastrectomy and the subsequent development of esophageal cancer, especially lower thoracic esophageal cancer, cannot be ruled out. Further studies are necessary to clarify a possible association.

Adult↗
PubMed1985

Intra-hepato-arterial infusions of cis-diamminedichloroplatinum (II) and 5-fluorouracil clinically effective for malignant liver tumors.

Four hepatocellular cancer patients and 11 metastatic liver cancer patients were treated with intra-hepato-arterial infusions of cis-diamminedichloroplatinum (II) plus 5-fluorouracil. Cis-diamminedichloroplatinum (II) (25-35 mg/m2) was given once a week, 5-fluorouracil (150-180 mg/m2) was infused daily. A partial response was obtained in 3 of 4 patients with primary cancer and in 5 of 9 evaluable metastatic cancer patients; the mean response durations were 27+ weeks in the former and 47+ weeks in the latter. However, severe bone marrow suppression occurred in 4 patients; 3 died of septicemia (2 cases) and massive intra-tracheal bleeding, respectively. This combined intra-hepato-arterial chemotherapy exerts a synergistic anticancer effect on malignant liver tumors, however, the related bone marrow suppression remains to be overcome.

Adult↗
PubMed1985

[Relationship between cholecystectomy and the subsequent development of colorectal carcinoma].

In order to clarify the presence or absence of a relationship between cholecystectomy and the subsequent development of colorectal carcinoma, we compared the incidence of previous cholecystectomy in 448 patients with colorectal cancer and in 1627 with gastric cancer, who had been treated in our clinic during the 21 year period through 1963 to 1983. There was no statistically significant difference in the incidence of previous cholecystectomy between patients with colorectal and gastric cancer. We then performed an historical cohort study covering 461 patients undergoing cholecystectomy for gallstone during the 32 year period from 1949 to 1981 for the subsequent occurrence of carcinoma of the colorectum and stomach. The observed incidence was one in colon cancer and six in gastric cancer, showing a similar proportion of the development of both carcinomas in our district. The present study showed no evidence of cholecystectomy being an increased risk for the development of colorectal carcinoma.

Adolescent↗
PubMed1980

Epidemiology of contact dermatitis from pesticides in Japan.

An epidemiological study was made of 216 patients with contact dermatitis from pesticides in Japanese rural regions from 1968 to 1970. They were analyzed according to conditions of use, sex, age, occupation, exposure, and season. The pesticides most often responsible were captafol (Difolatan) (28.7%), sulfurs (18.5%), highly and moderately toxic organic phosphates (18.1%), and chlorinated hydrocarbons (9.7%). Complications, sites of dermatitis, prognosis and factors contributing to onset of dermatitis are discussed.

Adult↗