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Biomedical subjects

T W Williams

Publications and source records attributed to T W Williams.

103 records · Page 6Linked to original sources
PubMedDate not supplied

Use of trimethoprim-sulfamethoxazole for treatment of infections due to Nocardia.

Trimethoprim-sulfamethoxazole (TMP-SMZ) was used for treatment of 34 patients with pulmonary or cutaneous nocardiosis. Of nine patients with primary cutaneous disease, eight had rapid resolution of their infection after short-term therapy and none have relapsed after a follow-up of more than six months. The 25 patients with pulmonary nocardiosis had a good clinical response, but three of five (60%) who completed less than three months of therapy relapsed within four weeks. Of the 10 patients who completed four to six months of therapy, only one (10%) relapsed and this relapse was due to drug resistance. By the method of serial dilution in agar, 96% of 59 isolates of Nocardia had MICs of SMZ of less than 25 micrograms/ml. Fewer than 20% were susceptible to 2.5 micrograms of TMP/ml. Synergy between TMP and SMZ was usually present with ratios of TMP to SMZ of 1:5, 1:1, or 5:1, but was less common at a ratio of 1:20. Disk susceptibility testing was easy to perform and readily separated sensitive from resistant strains. TMP-SMZ is highly effective for the treatment of nocardiosis, but the question of whether it is more effective clinically than a sulfonamide alone remains unanswered.

Adult↗
PubMedDate not supplied

"Contribution to the Question of Pneumotyphus": a discussion of the original article by J. Ritter in 1880.

In 1880, Dr. J. Ritter wrote a classic infectious disease article (originally in German) on psittacosis entitled, "Contribution to the Question of Pneumotyphus." In this article, Ritter meticulously describes a mini-epidemic--in which three individuals died--of seven cases of psittacosis caused by parrots and finches caged in the study of his brother's house in Uster, Switzerland. Ritter accurately identified the study as the site of the source of infection, considered the birds as vectors, and determined both the incubation period and the nontransmissability of the disease from human to human. His main differential diagnosis was a choice between typhoid and typhus; with pneumonitis being the main pathologic finding, he coined the term pneumotyphus. Ritter's article elegantly describes the clinical presentation, epidemiology, pathologic findings, and natural history of infection due to Chlamydia psittaci. Ritter's astute observations and their significance are discussed in this paper.

Adult↗
PubMedDate not supplied

Combined clinical and laboratory studies with carbenicillin and ticarcillin: use in infections involving anaerobic bacteria.

Eleven patients with serious infections involving anaerobic bacteria were treated with carbenicillin (four patients) or ticarcillin (seven patients). All patients were cured clinically and bacteriologically of their infections. An in vitro study testing 157 recently isolated anaerobic organisms against 11 antibiotics showed chloramphenicol, carbenicillin, and ticarcillin at blood level concentrations to be inhibitory to more anaerobic strains than the other eight antibiotics tested. Ticarcillin and carbenicillin appear to be safe and effective and deserve further consideration for use in the therapy of anaerobic infections.

Abdomen↗
PubMedDate not supplied

Combined effects of ticarcillin and cefazolin on blood coagulation and platelet function.

Combined intravenous infusions of ticarcillin and cefazolin given to normal volunteers resulted in a functional platelet defect which appeared to be determined primarily by the dose and duration of treatment with the penicillin component. No effect on soluble blood coagulation factors was evident. Acute administration of corticosteroids did not influence the prolonged bleeding times induced by extended ticarcillin infusions.

Blood Coagulation↗
PubMedDate not supplied

Case report. Pseudomonas puncture wound osteomyelitis in adults.

Pseudomonas osteomyelitis following a puncture wound is commonly reported in children, but very few cases have been recorded in adults. We describe ten adult patients with well documented Pseudomonas aeruginosa osteomyelitis consequent to puncture wounds. The disease in adults is similar to that in children with respect to bone involved, clinical features, and preferred antibiotic therapy; however, the prognosis for complete recovery without permanent sequelae seems much better in adults.

Adolescent↗