Biomedical subjects
T W Sheehy
Publications and source records attributed to T W Sheehy.
Sickle cell hepatopathy.
Hepatic dysfunction is a common finding in patients with sickle cell disease but viral hepatitis appears to be an unusual complication in the adult SS patient. Only five cases of viral hepatitis were recorded in 378 admissions for SS crisis. In contrast, hepatic crisis occurred as a distinct event in 9% of 88 patients with sickle cell anemia. This entity must be differentiated from acute cholecystitis or viral hepatitis. Transiently abnormal results of hepatitic function tests were observed in another 26 patients with extrahepatic crisis. Cirrhosis is relatively common and often the terminal event in SS disease. Choledocholithiasis and cholecystitis are infrequent complications despite the prevalence of gallstones in SS anemia.
The hematologic changes caused by alcohol.
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Treatment of sickle cell disease.
The treatment of sickle cell disease requires familiarity with the medical manifestations of the vaso-occlusive and hematologic crises and their complications. This discussion deals with treatment of the sickle cell crises and major clinical manifestations of the disease. At present, treatment is primarily symptomatic despite intensive efforts during the past decade to provide more definitive therapy.
To treat or not to treat hypertension in the aged.
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Geotrichum septicemia.
Although disseminated geotrichosis is an unusual disease (to our knowledge, only six cases have been reported), Geotrichum candidum is not a very virulent fungus. In our case, there was neutrophillic phagocytosis of the arthrosphores of G candidum, with rapid clearance of the fungus from the plasma of a chronically ill patient whose immune defenses were still intact.
Platelets and drugs.
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Upper gastrointestinal hemorrhage.
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Upper gastrointestinal hemorrhage.
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Giardia-induced malabsorption in pancreatitis.
This report deals with the onset of Giardia-induced, primary malabsorption in patients with chronic pancreatitis. To our knowledge, this association has been reported only once previously. A further review of the literature suggests that malnourished patients with chronic pancreatitis may be susceptible to G lamblia infection. Therapy for giardiasis rapidly reverses the diarrhea, malabsorption, and edema seen in these patients.
Letter: disseminated intravascular coagulation and severe falciparum malaria.
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Colitis associated with clindamycin therapy.
Clindamycin (7-chloro-7-deoxylincomycin) may induce mild or severe colitis. In 28 months, clindamycin-associated diarrhea was encountered in 8 patients who had received oral therapy. Severe, acute colitis was seen in 4 older patients, 3 of whom had acute pseudomembranous colitis and one who had an adynamic ileus mimicking an acute abdomen. Mild colitis with protracted diarrhea occurred in 4 younger patients who had mild, nonspecific inflammation in the rectum which responded to symptomatic treatment. The mechanism and true incidence of diarrhea as a sequel of clindamycin therapy are unknown. In all 8 patients, the use of clindamycin was arbitrary. Because of potentially serious gastrointestinal disturbance, including acute pseudomembranous colitis, clindamycin should be reserved for anaerobic and other serious infections.
How to set about diagnosing malabsorption.
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Sickle cell disease and the liver.
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Apathetic thyrotoxicosis causing gastrointestinal malabsorption.
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