Biomedical subjects

T W Belke

Publications and source records attributed to T W Belke.

13 recordsLinked to original sources

PubMed2005

Responding for sucrose and wheel-running reinforcement: effect of D-amphetamine.

The present study assessed the effect of D-amphetamine on responding maintained by wheel-running and sucrose reinforcement. Six male albino Wistar rats were placed in running wheels and exposed to a fixed-interval 30-s schedule that produced either a drop of 5% sucrose solution or the opportunity to run for 15 s as reinforcing consequences for lever pressing. Each reinforcer type was signaled by a different stimulus. Doses of 0.25, 0.5, 1.0, 1.5, and 3.0 mg/kg D-amphetamine were administered by i.p. injection 20 min prior to a session. As the dose increased, index of curvature values decreased toward zero and rate-dependency plots revealed increases in lower rates early in the interval and decreases in higher rates toward the end of the interval. Effects were similar in the presence of both stimuli. However, an analysis of post-reinforcement pauses and local response rates broken down by transitions revealed a differential effect. As the dose increased, local response rates following a wheel-running reinforcer were affected more than those following a sucrose reinforcer.

Animals↗

PubMed2001

The general matching law describes choice on concurrent variable-interval schedules of wheel-running reinforcement.

Six male Wistar rats were exposed to concurrent variable-interval schedules of wheel-running reinforcement. The reinforcer associated with each alternative was the opportunity to run for 15 s, and the duration of the changeover delay was 1 s. Results suggested that time allocation was more sensitive to relative reinforcement rate than was response allocation. For time allocation, the mean slopes and intercepts were 0.82 and 0.008, respectively. In contrast, for response allocation, mean slopes and intercepts were 0.60 and 0.03, respectively. Correction for low response rates and high rates of changing over, however, increased slopes for response allocation to about equal those for time allocation. The results of the present study suggest that the two-operant form of the matching law can be extended to wheel-running reinforcement. 'I'he effects of a low overall response rate, a short Changeover delay, and long postreinforcement pausing on the assessment of matching in the present study are discussed.

Animals↗

PubMed2001

Effects of cocaine on fixed-interval responding reinforced by the opportunity to run.

Rate-dependent drug effects have been observed for operant responding maintained by food, water, heat, light onset, electrical brain stimulation, shock-stimulus termination, and shock presentation. The present study sought to determine if the effects of cocaine on lever pressing maintained by the opportunity to run could also be described as rate dependent. Seven male Wistar rats were trained to respond on levers for the opportunity to run in a wheel. The schedule of reinforcement was fixed-interval 60 s, and the reinforcing consequence was the opportunity to run for 60 s. On this schedule, overall rates of responding were low, usually below six presses per minute, and pauses frequently exceeded the 60-s interval. Despite these differences, an overall scalloped pattern of lever pressing was evident for each rat. Doses of 1, 2, 4, 8, and 16 mg/kg cocaine were administered 10 min prior to a session. Only at the 16 mg/kg dose did the responding of the majority of rats change in a manner suggestive of a rate-dependent drug effect. Specifically, lower response rates at the beginning of the intervals increased and higher rates at the end of the intervals decreased, as indicated by the fact that slopes from the regression of drug rates on control rates decreased. These data provide tentative support for the generalization of rate-dependent effects to operant responding maintained by wheel running. Differences in the baseline performance maintained by wheel running compared to those for food and water point to the need for further experimentation before this effect can be firmly established.

Animals↗

PubMed2000

Sex differences in the anatomical distribution of melanocytic nevi in Canadian Hutterite children.

BACKGROUND: Studies of the distribution of melanocytic nevi (MN) and/or cutaneous malignant melanoma (CMM) in white populations have commonly observed greater numbers of MN and CMM on the torsos of males and on the limbs of females. The most commonly cited explanation for this sex difference is differential sunlight exposure of body subsites due to gender differences in clothing styles and recreational activities. Less common, but more speculative, explanations suggest hormonal differences or regional differences in melanocytes across body subsites. OBJECTIVE: The purpose of the present study was to evaluate these explanations in light of sex differences in the anatomical distribution of nevi in Canadian Hutterite children whose traditional religious costume protects them from sun exposure. METHODS: Nevi counts from 178 male and 154 female children, aged 5 to 15 years, from 23 Central Alberta Hutterite colonies were broken down by age and body subsite. RESULTS: At age levels from 6 to 15 years, males had greater nevus counts on the torso, whereas females had greater counts on the upper and lower limbs. CONCLUSION: The appearance of this distribution of nevi in sun-protected children as early as age 6 is problematic for explanations based on differential sunlight exposure and hormonal changes at puberty.

Adolescent↗

PubMed2000

Varying wheel-running reinforcer duration within a session: effect on the revolution-postreinforcement pause relation.

Previous investigations of wheel-running reinforcement that manipulated reinforcer duration across conditions showed a strong relation between wheel-running rate and average postreinforcement pause (PRP) duration. To determine if the basis of this relation across conditions was a local effect of fatigue or satiation, the correlation between revolutions run and the duration of the immediately following PRP was investigated under conditions in which reinforcer duration was either constant or variable within a session. Seven male Wistar rats pressed a lever on a fixed-interval 60-s reinforcement schedule with the opportunity to run for 60 s as the reinforcing consequence. In the constant-duration condition, the duration of the reinforcer was always 60 s. In the variable-duration condition, the duration of the reinforcer varied between 2 and 240 s with a mean of 60 s. Mean correlations between revolutions run and the next PRP duration for constant, variable, and constant conditions were -.07, .20, and -.07, respectively. Although the positive correlation in the variable-duration condition is consistent with an effect of momentary fatigue or satiation, little of the variance in PRP duration appears to be attributable to these factors.

Animals↗

PubMed2000

Studies of wheel-running reinforcement: parameters of Herrnstein's (1970) response-strength equation vary with schedule order.

Six male Wistar rats were exposed to different orders of reinforcement schedules to investigate if estimates from Herrnstein's (1970) single-operant matching law equation would vary systematically with schedule order. Reinforcement schedules were arranged in orders of increasing and decreasing reinforcement rate. Subsequently, all rats were exposed to a single reinforcement schedule within a session to determine within-session changes in responding. For each condition, the operant was lever pressing and the reinforcing consequence was the opportunity to run for 15 s. Estimates of k and R(O) were higher when reinforcement schedules were arranged in order of increasing reinforcement rate. Within a session on a single reinforcement schedule, response rates increased between the beginning and the end of a session. A positive correlation between the difference in parameters between schedule orders and the difference in response rates within a session suggests that the within-session change in response rates may be related to the difference in the asymptotes. These results call into question the validity of parameter estimates from Herrnstein's (1970) equation when reinforcer efficacy changes within a session.

Animals↗

PubMed1997

Running and responding reinforced by the opportunity to run: effect of reinforcer duration.

The present study investigated the effect of reinforcer duration on running and on responding reinforced by the opportunity to run. Eleven male Wistar rats responded on levers for the opportunity to run in a running wheel. Opportunities to run were programmed to occur on a tandem fixed-ratio 1 variable-interval 30-s reinforcement schedule. Reinforcer duration varied across conditions from 30 to 120 s. As reinforcer duration increased, the rates of running and lever pressing declined, and latency to lever press increased. The increase in latency to respond was consistent with findings that unconditioned inhibitory aftereffects of reinforcement increase with reinforcer magnitude. The decrease in local lever-pressing rates, however, was inconsistent with the view that response strength increases with the duration of the reinforcer. Response rate varied inversely, not directly, with reinforcer duration. Furthermore, within-session data challenge satiation, fatigue, and response deprivation as determinants of the observed changes in running and responding. In sum, the results point to the need for further research with nonappetitive forms of reinforcement.

Animals↗

PubMed1994

Increasing and signaling background reinforcement: effect on the foreground response-reinforcer relation.

Herrnstein's (1970) hyperbolic matching equation describes the relationship between response rate and reinforcement rate. It has two estimated parameters, k and Re. According to one interpretation, k measures motor performance and Re measures the efficacy of the reinforcer maintaining responding relative to background sources of reinforcement. Experiment 1 tested this interpretation of the Re parameter by observing the effect of adding and removing an additional source of reinforcement to the context. Using a within-session procedure, estimates of Re were obtained from the response-reinforcer relation over a series of seven variable-interval schedules. A second, concurrently available variable-interval schedule of reinforcement was added and then removed from the context. Results showed that when the alternative was added to the context, the value of Re increased by 107 reinforcers per hour; this approximated the 91 reinforcers per hour obtained from this schedule. Experiment 2 investigated the effects of signaling background reinforcement on k and Re. The signal decreased Re, but did not have a systematic effect on k. In general, the results supported Herrnstein's interpretation that in settings with one experimenter-controlled reinforcement source, Re indexes the strength of the reinforcer maintaining responding relative to uncontrolled background sources of reinforcement.

Animals↗

PubMed1994

Choice between reliable and unreliable reinforcement alternatives revisited: Preference for unreliable reinforcement.

Pigeons' choices between a reliable alternative that always provided food after a delay (i.e., 100% reinforcement) and an unreliable one that provided food or blackout equally often after a delay (i.e., 50% reinforcement) was studied using a discrete-trials concurrent-chains procedure modified to prevent choice between alternatives following a blackout outcome. Initial links were fixed-ratio 1 schedules, and terminal links were fixed-time schedules. Stimuli presented during the terminal-link delays were correlated with the food and blackout outcomes. In Experiment 1, terminal-link durations were varied. With short terminal links (i.e., 10 s), 6 of 8 subjects showed strong preference for the 50% side. As terminal-link duration increased to 30 s, preference, regardless of direction, became less extreme. In Experiment 2, the side-key location of the 50% and 100% alternatives was reversed for 3 subjects. Preference for the 50% alternative reoccurred following the key reversal. When a 5-s separation was subsequently interposed between the initial and terminal links for both alternatives, all birds reversed to a preference for the 100% side. In general, the strong preference for the 50% side was qualitatively consistent with the expectation that the procedure enhanced the conditioned-reinforcement effectiveness of the food-associated terminal-link stimulus on the 50% side. Implications of the results for various accounts of choice of the 50% alternative are discussed.

Journal Article↗

PubMed1992

Maximizing versus matching on concurrent variable-interval schedules.

Maximization and matching predictions were examined for a time-based analogue of the concurrent variable-interval variable-ratio schedule. One alternative was a variable interval whose time base operated relatively independent of the schedule chosen, and the other was a discontinuous variable interval for which timing progressed only when selected. Pigeons switched between schedules by pecking a changeover key. The maximization hypothesis predicts that subjects will show a bias toward the discontinuous variable interval and undermatching; however the obtained results conformed closely to the predictions of the matching law. Finally, a quantitative comparison was made of the bias and sensitivity estimates obtained in published concurrent variable-interval variable-ratio analogue studies. Results indicated that only the ratio-based analogue of the concurrent variable interval variable ratio studied by Green, Rachlin, and Hanson (1983) produced significant bias toward the variable-ratio alternative and undermatching, as predicted by reinforcement maximization.

Journal Article↗

PubMed1990

Suboptimal choice in a percentage-reinforcement procedure: effects of signal condition and terminal-link length.

Pigeons' choice between reliable (100%) and unreliable (50%) reinforcement was studied using a concurrent-chains procedure. Initial links were fixed-ratio 1 schedules, and terminal links were equal fixed-time schedules. The duration of the terminal links was varied across conditions. The terminal link on the reliable side always ended in food; the terminal link on the unreliable side ended with food 50% of the time and otherwise with blackout. Different stimuli present during the 50% terminal links signaled food or blackout outcomes under signaled conditions but were uncorrelated with outcomes under unsignaled conditions. In signaled conditions, most pigeons displayed a nearly exclusive preference for the 100% alternative when terminal links were short (5 or 10 s), but with terminal links of 30 s or longer, preference for the 100% alternative was sharply reduced (often to below .5). In unsignaled conditions, most pigeons showed extreme preference for the 100% alternative with either short (5 s) or longer (30 s) terminal links. Thus, pigeons' choice between reliable and unreliable reinforcement is influenced by both the signal conditions on the unreliable alternative and the duration of the terminal-link delay. With a long delay and signaled outcomes, many pigeons display a suboptimal tendency to choose the unreliable side.

Animals↗

PubMed1989

The effect of logarithmic transformation on estimating the parameters of the generalized matching law.

The generalized matching law was initially stated as a nonlinear relation between reinforcement-rate ratios and response-rate ratios. Often, the variables of the law are transformed logarithmically to remove the nonlinearity; empirical results are then fit to the model through least-squares regression. However, the logarithmic expression of the matching law is a biased statistical representation of the law itself. In particular, the logarithmic transformation alters the quantitative conclusions to be drawn from a least-squares regression analysis. A Monte Carlo study of the effect of transforming matching-law data demonstrated that (a) the estimates of one or both of the parameters of the generalized matching law are biased, (b) the measure of goodness of fit (R(2)) is inaccurate, and (c) predictions generated by the fitted parameters are incorrect. Alternative approaches to logarithmic transformations are shown to alleviate these problems.

Journal Article↗

PubMed1989

Determinants of choice for pigeons and humans on concurrent-chains schedules of reinforcement.

Concurrent-chains schedules of reinforcement were arranged for humans and pigeons. Responses of humans were reinforced with tokens exchangeable for money, and key pecks of 4 birds were reinforced with food. Variable-interval 30-s and 40-s schedules operated in the terminal links of the chains. Condition 1 exposed subjects to variable-interval 90-s and variable-interval 30-s initial links, respectively. Conditions 2 and 3 arranged equal initial-link schedules of 40 s or 120 s. Experimental conditions tested the descriptive adequacy of five equations: reinforcement density, delay reduction, modified delay reduction, matching and maximization. Results based on choice proportions and switch rates during the initial links showed that pigeons behaved in accord with delay-reduction models, whereas humans maximized overall rate of reinforcement. As discussed by Logue and associates in self-control research, different types of reinforcement may affect sensitivity to delay differentially. Pigeons' responses were reinforced with food, a reinforcer that is consumable upon presentation. Humans' responses were reinforced with money, a reinforcer exchanged for consumable reinforcers after it was earned. Reinforcers that are immediately consumed may generate high sensitivity to delay and behavior described as delay reduction. Reinforces with longer times to consumption may generate low sensitivity to delay and behavior that maximizes overall payoff.

Animals↗