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Biomedical subjects

T W Anderson

Publications and source records attributed to T W Anderson.

At least 37 records · Page 2Linked to original sources
PubMed1983

Accuracy of registration of invasive cervical cancer.

The quality of the data recorded by the British Columbia Cancer Registry for 521 new cases of invasive cervical cancer was evaluated. The registry's pathological diagnosis in all new registrations of invasive cervical cancer diagnosed in British Columbia between 1977 and 1979 was compared with a best estimate of the true diagnosis, which was determined from the results of the provincial cervical cytology screening program and the clinical charts at the Cancer Control Agency of British Columbia. The registry's data overestimated the true incidence of invasive cervical cancer by approximately 55%, since 184 (35%) of the cases were incorrectly registered. Of the 184, 141 (77%) were cases of preinvasive cervical cancer, 26 (14%) did not meet the criteria for a true case (i.e., they were not newly diagnosed in British Columbia between 1977 and 1979) and 17 (9%) were cases of invasive cancer of another primary site. In addition, 28 cases of invasive cervical cancer diagnosed in the province during the study period had not been reported to the registry. Thus, both over-reporting and under-reporting occurred. There is a need for constant evaluation of registry data if cancer registries are to fulfil their potential contribution to cancer control programs and research.

Adult↗
PubMed1983

A randomized placebo-controlled trial of ultraviolet light in the treatment of superficial pressure sores.

Ultraviolet (UV) light treatment of pressure sores enjoyed widespread popularity for many years, but recently its effectiveness has been increasingly questioned. Surprisingly, it appears that this form of treatment has never been tested by a randomized placebo-controlled trial. Eighteen patients residing in the Extended Care Unit of the Health Sciences Centre Hospital at the University of British Columbia and suffering from superficial pressure sores of recent onset were therefore randomly assigned to active and placebo treatment groups. Since treatment procedures appeared identical in both groups, both patients and hospital staff were blind as to individual allocation. Sixteen patients completed the study. Mean time to complete healing was 6.3 weeks in the UV treated group, significantly (P less than .02) less than the mean of 8.4 weeks in the placebo group. This difference persisted unchanged when each patient's age and the initial size of the sore were taken into account by an analysis of covariance. Thus, in spite of growing skepticism about its effectiveness, it appears that UV light may play a useful role in the treatment of pressure sores, and a systematic evaluation of different treatment protocols seems to be justified.

Aged↗
PubMed1979

Cold snaps, snowfall and sudden death from ischemic heart disease.

The short-term effect of low temperature on the incidence of ischemic heart disease over a 15-year period was examined. To reduce confounding by other seasonal factors the analysis was restricted to the winter months and was based on the change in the daily rate of sudden death at the time of cold snaps (arbitrarily defined as days on which the mean temperature was at least 4.4 degrees C lower than the day before) and around the time of heavy snowfalls. A statistically significant increase in the daily rate of sudden death at the time of cold snaps occurred only in men under 65 years of age, and even in this group the effect was of relatively small magnitude (+16%) compared with the large change in rate following heavy snowfalls (+88%). Among persons aged 65 years or over cold snaps had virtually no effect, and only the men in this group showed an increased daily rate of sudden death following a snowfall. These results suggest that much of the increased frequency of death from ischemic heart disease in winter, particularly among the elderly, must be due to factors other than short-term cold stress.

Adult↗
PubMed1979

Does screening by "Pap" smears help prevent cervical cancer? A case-control study.

The Papanicolaou (Pap)-smear history of 212 cases of invasive cervical cancer was compared with that of 1060 age-matched controls drawn from neighbours. In the 5 years before the year of diagnosis 32% of the cases had been screened by Pap smear, compared with 56% of the controls. This difference was statistically highly significant (p less than 0.0001) and indicated a relative risk of invasive cancer of 2.7 in women who had not been screened by Pap smear, compared with those who had. Differences in Pap-smear history between cases and controls persisted when the data were stratified by age, income, education, marital history, smoking habit, employment status, and access to medical care. These results support the belief that the Pap smear is an effective screening procedure for invasive cervical cancer.

Adenocarcinoma↗
PubMed1979

The sex differential in ischaemic heart disease: trends by social class 1931 to 1971.

The comparison of trends in ischaemic heart disease (IHD) mortality in different social classes is confounded by historical changes in diagnostic techniques and statistical classification, and possibly by different standards of diagnostic accuracy in the different social classes. The problems can be circumvented by taking advantage of the fact that in middle age (45 to 64) the IHD death rate is much higher in men than in women. This large sex differential is not present in any of the other causes of death with which IHD might easily be confused and it is therefore relatively unaffected by diagnostic errors and variation in classification. The changes that have occurred in the sex differential in Social Classes I and V in England and Wales between 1931 and 1971 confirm anecdotal clinical reports that the male vulnerability to IHD appeared first in Social Class I (professionsl). By 1971 Social Class V (unskilled) had caught up, and the men in these two social classes now experience an almost identical excess in cardiovascular death rate compared with their wives.

Coronary Disease↗
PubMed1978

Re-examination of some of the Framingham blood-pressure data.

Mathematical smoothing of data for the Framingham study leads to the conclusion that there is no threshold of normality for blood-pressure. A reasonable therapeutic goal might be "the lower the better". However, examination of the unsmoothed Framingham data indicates that while systolic pressures fit this no-threshold model reasonably well, changes in diastolic pressure below about 90 mm Hg have little or no prognostic significance. The poor fit of the diastolic points to the no-threshold model may also help to explain why at Framingham raised systolic pressure seemed to have a greater impact than raised diastolic pressure.

Blood Pressure↗