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Biomedical subjects

T V Colby

Publications and source records attributed to T V Colby.

233 records · Page 13Linked to original sources
PubMed1981

Hodgkin's disease at autopsy: 1972-1977.

The autopsies of 80 patients with Hodgkin's disease (HD) were reviewed. Nearly one-third of the patients died without evidence of HD at autopsy. Four patients died with clinically unsuspected HD. Infection was the most common cause of death but a significant number of patients died of complications of therapy, both benign and malignant, including five patients with hematologic or de novo lymphoid malignancies. There was wide histologic variation of HD at autopsy and many cases had a pleomorphic appearance with few of the typical features of Hodgkin's disease. Fibrous nodules interpreted as sites of eradicated HD were found in many organs, most commonly lymphoreticular. Nonfatal histopathologic effects of therapy were common and specifically assessed thyroid and gonads.

Adolescent↗
PubMed1981

Lymph node biopsy in mycosis fungoides.

Ninety lymph node biopsy specimens from 76 patients with mycosis fungoides (MF) were reviewed. Dermatopathic lymphadenopathy was the most common change found in biopsies of palpable lymph nodes obtained from patients with MF. The paracortical expansion and histiocytes with elongated, folded, and delicate nuclei were characteristic. Lymph node involvement by MF lymphoma had a broad spectrum of histologic appearance. Most commonly, MF lymphoma was composed of atypical, often hyperconvoluted, lymphoid cells showing a wide variation in size. The pretreatment biopsies from 38 patients were graded according to the number of atypical small lymphocytes (AL) in the paracortical region and the results were correlated with survival. No significant differences in survival were found among the various grades, which ranged from dermatopathic lymphadenopathy without AL to frank involvement by MF lymphoma. Patients with more extensive skin disease tended to have a higher grade and to do poorly.

Biopsy↗
PubMed1981

Pulmonary involvement of malignant histiocytosis: a clinicopathologic spectrum.

We described five patients in whom pulmonary malignant histiocytosis was histologically confirmed during life. Pulmonary symptoms dominated the clinical presentation in three patients, and one patient had a 5-year history of pulmonary malignant histiocytosis controlled by steroids. Radiologic features were nonspecific. Most patients had bilateral reticulonodular or fluffy infiltrates. Recurrent pulmonary histiocytosis in one patient was manifest by bilateral pulmonary nodules. Pathologically, pulmonary infiltration by malignant histiocytosis followed the normal lymphatic pathways of the lung along bronchovascular rays, in interlobular septa, and within the pleura. Unusual features included marked septal edema and fibrosis out of proportion to the degree of infiltration, and in one case, the marked predilection fo the infiltrate to occlude small airways ("malignant histiocytosis bronchiolitis"). Three patients had microscopic nondestructive nodules adjacent to lymphatics. A pulmonary recurrent in one patient was composed of large monomorphous nodules with central necrosis and prominent vascular infiltration by malignant cells. The pulmonary infiltrate of malignant histiocytosis was often heterogeneous, and included variable numbers of lymphocytes and plasma cells intermingled with alveolar macrophages and metaplastic alveolar lining cells. The cytologic features of the infiltrate varied from benign to pleomorphic and obviously malignant. Histologic features which may obscure the correct diagnosis, as they did initially in three of our cases, include: malignant histiocytic bronchiolitis, marked septal edema and fibrosis; the heterogeneous cellular infiltrate; and in one case, benign cytologic features. The most valuable initial clue to the correct diagnosis was the tendency of the infiltrates to follow lymphatics of the lung.

Adolescent↗
PubMed1981

Differentiation of chronic lymphocytic leukemia from Hodgkin's disease using immunologic marker studies.

Four consecutive lymph node biopsies from one patient showed features typical of lymphocyte-pre-dominant Hodgkin's disease. When the patient developed lymphocytosis of the peripheral blood and a staging bone marrow biopsy was found to have nodular lymphoid infiltrates atypical for Hodgkin's disease, the fourth node biopsy was performed in order to perform immunologic marker studies. A monoclonal cell population was identified and the lymph nodes were interpreted as chronic lymphocytic leukemia mimicking lymphocyte-predominant Hodgkin's disease. The diagnostic usefulness of immunologic marker studies stressed.

Diagnosis, Differential↗
PubMed1981

Dermatopathic lymphadenopathy. Comparison of cases associated and unassociated with mycosis fungoides.

Thirty-three biopsies showing dermatopathic lymphadenopathy were obtained from patients with documented cutaneous mycosis fungoides and were studied together with an equal number of dermatopathic lymph nodes derived from patients without evidence of mycosis fungoides. The nodes were evaluated for a variety of histologic features including mitotic figures, immunoblasts, and in particular for the number of atypical cerebriform lymphocytes. Atypical lymphocytes were found to be equally as frequent among both groups of dermatopathic lymph nodes without any statistically significant differences in quantitation or distribution. Similarly, no other morphologic variable was found which would allow an objective distinction of dermatopathic lymphadenopathy from patients with or without mycosis fungoides.

Adolescent↗
PubMed1980

Nodular lymphoma: clinicopathologic correlations of parafollicular small lymphocytes and degree of nodularity.

One hundred thirty-four cases of Stages III and IV nodular non-Hodgkin's lymphoma, subclassified according to the criteria of Rappaport, were assessed for parafollicular small lymphocytes and vascular prominence and degree of nodularity. Statistically significant correlations with survival were found for the groups in the Rappaport classification but not for groups based on the amount of parafollicular small lymphocytes or vascular prominence (PSL grading). In the subgroup of patients with nodular poorly differentiated lymphocytic lymphoma, a significant difference in survival time was found between those with pure nodular patterns and those with 25--60% diffuse areas.

Humans↗
PubMed1980

The histology of the initial relapse of Hodgkin's disease.

The histology of relapsing Hodgkin's disease was compared with that of the original diagnostic biopsy in 56 patients. A criterion for inclusion in this study was relapse in an untreated site, thereby excluding all patients initially treated with chemotherapy. THose patients selected for study were initially treated with local radiotherapy, and relapsed outside the initial radiation fields. There was an impressive maintenance of the histologic appearance in the relapse biopsies: a change in histology was seen only in a small percentage of cases. The histologic relationship of so-called "cellular phase" of nodular sclerosing Hodgkin's disease to classical nodular sclerosing Hodgkin's disease was confirmed. Those patients with a relapse-free interval greater than one year more often had an epithelioid cell reaction (granulomatous reaction) in their biopsy material in contrast to those who relapsed in less than one year.

Eosinophils↗
PubMed1980

Malakoplakia of the lung: a report of two cases.

We have presented the clinical, radiologic and pathologic features of 2 patients with pulmonary malakoplakia. The histologic features, including diagnositc Michaelis-Gutmann bodies, were identical to those in the urinary tract where malakoplakia is recognized as an abnormal cellular response to chronic bacterial infection. Both patients were immunocompromised: one a cardiac transplant, the other a patient with Hodgkin's disease. The lesions were focal and showed some response to antibiotic therapy, although other disease processes progressed in both patients. Malakoplakia should be added to the list of unusual infections occurring at unusual sites in compromised hosts.

Heart Transplantation↗
PubMed1980

Carcinoid tumor of the bladder. A case report.

A carcinoid tumor of the bladder was documented by light and electron microscopy. The tumor was small and benign, but definitely neoplastic. Dense-core intracytoplasmic granules were found on electron microscopy.

Adult↗
PubMed1980

Pathogenesis of veno-occlusive liver disease after radiation.

Radiation-induced liver disease is characterized structurally by progressive fibrous obliteration of central veins (veno-occlusive disease [VOD]). The pathogenesis is unknown. Samples of liver from 11 patients with radiation-induced VOD were studied by light and electron microscopy for evidence of central vein thrombosis. The patients had received fractionated radiation with total doses of 1,850 to 4,050 rads, or single doses of 1,000 rads. In addition, six patients had received chemotherapy. Although usually undetectable by light microscopy, fibrin was found in all samples, sometimes in large amounts, within central veins, and also often in the adjacent sinusoids. One sample had a small platelet aggregate. In two patients, portal veins also showed occlusive lesions. We postulate that ionizing radiation injures preferentially the endothelial cells of central veins, which leads to focal deposition of fibrin. The resulting fibrin network is eventually replaced by collagen, causing fibrous occlusion. In several patients, this type of liver injury occurred at radiation doses conventionally considered safe even in the absence of chemotherapy.

Adolescent↗
PubMed1979

Malignant lymphomas involving the salivary glands.

Malignant lymphomas involving the salivary glands are probably more common than has been previously recognized. They must be differentiated from the benign lymphoepithelial lesion, although there may be an association between the two. The entire histologic spectrum of malignant lymphomas found at other sites can be seen in the salivary gland. In this study of 59 patients with lymphoma affecting the salivary gland, a large percentage were found to have disseminated disease. We recommend the same rigorous clinical evaluation and staging procedures as used in patients who present with primary lymph node involvement.

Adolescent↗
PubMed1978

Malakoplakia. Two unusual cases which presented diagnostic problems.

Two unusual cases of malakoplakia are presented. Both cases occurred outside the urinary tract (retroperitoneum and anus) and were diagnostic problems due to the paucity of Michaelis-Guttman bodies. One case mimicked a retroperitoneal malignant fibrous histiocytoma and the other a common perianal abcess.

Abdominal Neoplasms↗
PubMedDate not supplied

Multilobated B cell lymphomas. A study of 7 cases.

Seven cases of multilobated lymphomas with B cell surface markers are presented. Clinical, histological, ultrastructural and immunohistochemical features are detailed. These observations serve to underscore the importance of not relying on morphology alone for the phenotypic classification of non-Hodgkin's lymphomas.

Adolescent↗
PubMedDate not supplied

Diffuse pulmonary lymphangiomatosis: CT findings.

OBJECTIVE: Our objective was to determine and report the CT findings in patients with diffuse pulmonary lymphangiomatosis (DPL). MATERIALS AND METHODS: We retrospectively reviewed the CT findings in eight patients with pathologically proven DPL. The patients ranged in age from 3 to 35 years (mean 15 years) and included four male and four female patients. The CT scans were analyzed for type of pulmonary infiltrative process and its distribution, presence or absence of pleural fluid or thickening, and presence or absence of thoracic lymphadenopathy. RESULTS: The main abnormality seen on conventional and high resolution CT in all patients was smooth thickening of the interlobular septa and bronchovascular bundles. Seven of eight patients had patchy bilateral areas of ground-glass attenuation. All eight patients had diffuse increased attenuation of the mediastinal fat, approximating that of water, and mild bilateral perihilar infiltration. Seven of the eight had bilateral pleural effusions or smooth thickening of the pleura (or both), and two had regions of calcified pleural thickening. CONCLUSION: The constellation of CT features of DPL is distinctive and includes diffuse, smooth thickening of interlobular septa and bronchovascular bundles with extensive infiltration of the mediastinal fat and associated perihilar infiltration. Since the CT findings described are suggestive but not pathognomonic, definitive diagnosis requires lung biopsy.

Adolescent↗
PubMedDate not supplied

Utility of bronchoalveolar lavage in the diagnosis of drug-induced pulmonary toxicity.

Two hundred consecutive bronchoalveolar lavages (BALs) performed at Mayo Clinic were retrospectively reviewed. The BAL specimens were evaluated for nuclear enlargement, hyperchromasia and increased cytoplasmic staining density as possible cytologic markers of cytotoxic drug effects. Of the 200 patients whose lavages were examined, 178 had sufficient clinical data for study. Thirty-six BAL specimens had cytologic changes consistent with drug-induced pulmonary toxic effects. Twenty-three of the 36 patients had concurrent or subsequent lung tissue available for evaluation; 10 of the 23 showed histologic evidence of cytotoxic effects. The results indicate that BAL is a safe and useful procedure, not only for the assessment of suspected pulmonary infection in immunocompromised patients, but also for the investigation of drug-induced pulmonary disease.

Biopsy↗