[Clinical study on DIC in urological malignancies].
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Biomedical subjects
Publications and source records attributed to T Umeyama.
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This report presents a case of colonic adenoma which developed after ureterosigmoidostomy. A 71-year-old man was initially treated by total cystectomy and ureterosigmoidostomy for transitional cell carcinoma of the bladder in 1970. In 1983, a routine checkup revealed urinary occult blood. A barium enema x-ray showed a polypoid lesion in the sigmoid colon. Colonoscopy confirmed the presence of the polyp adjacent to the ureteral stoma. The biopsy findings were interpreted as villous adenoma with severe atypia. This tumor was removed endoscopically. This is the seventh case report of neoplasia occurring in the sigmoid colon after ureterosigmoidostomy in Japan. Review of the pertinent literature indicates that patients who have undergone this type of urinary diversion have an increased risk of development of large bowel neoplasia. Adequate and regular surveillance of these patients has been suggested in order to help in early detection.
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Long-term intra-arterial infusion chemotherapy with Adriamycin (ADM) was performed in cases of bladder cancer prior to total cystectomy. This report describes the effects in 13 cases evaluated more than 3 weeks after infusion of 10 mg ADM once or twice weekly. An oblique skin incision approximately 10 cm long was made in the gluteal region to expose the gluteus maximus muscle. A teflon catheter was then inserted into the gluteal artery and fixed; the distal end was brought out from under the skin in the precordial region. A similar procedure was performed on the contralateral side. The catheter was inserted through the superior and inferior gluteal arteries in five and eight cases, respectively. In the former group, partial response was obtained in two cases, minimal response in two and no response in one, so that primary tumor remission was evident in 40% of the cases. In the latter group, all cases but one attained partial response, i.e., remission was seen in 87.5% of cases treated by inferior gluteal infusion. Skin erosion of the gluteal, perineal, and anal regions and sciatica-like pain were observed in some cases; however neither myocardial effect nor bone marrow suppression, which have been reported as side-effects of ADM, were observed in any of the cases. These results suggest that this therapeutic modality could be effective in the preoperative work-up of candidates for total cystectomy, and also that it could be useful in the treatment of patients in whom total cystectomy is contraindicated.
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This is a case report of a localized amyloidosis of the ureter presented with gross hematuria. Amyloidosis of the ureter is a rare entity and 21 cases have been collected from the Japanese and English literature. It is believed to be difficult to diagnose before surgery and almost all the cases were treated by nephrectomy. After malignancy was denied, autotransplantation combined with psoas hitch procedure was carried out in order to preserve the kidney. This is the second case of ureter amyloidosis treated by autotransplantation. Amyloidosis was confirmed with Congo red stain and electronmicroscopy of which characteristics is discussed in detail.
Renal cell carcinoma in a solitary kidney is rather rare. We present a case of this condition occurring in a 50-year-old man. He was treated by partial nephrectomy and temporary hemodialysis for postoperative acute renal failure. Perusal of the literature reveals that in situ partial nephrectomy, if possible, seems to be a reasonable treatment of choice for renal cell carcinoma in a solitary kidney. This is the fifth case ever reported in Japan.
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Clinical studies on postoperative complications and prognosis were done on 27 patients who had undergone cystectomy at our hospital. Thirty one postoperative complications were seen in 16 patients. Early complications which developed within 3 months of operation were more frequent (25 cases). They included pyelonephritis (5 cases), wound infection (4 cases), pulmonary complications (2 cases), cardiovascular complications (2 cases), ileus (2 cases) and delayed ambulance (2 cases) in decreasing order of frequency. Complications related to urinary diversion were observed in 4 out of 6 late complications. Reoperation secondary to surgical complications were done in 6 cases. Four of the 6 reoperations were related to gastrointestinal complications, all of which would be fatal if left untreated. Postoperative followup period ranged from 3 weeks to 49 months with a mean period of 12.8 months. The present status of the patients is as follows: 16 patients alive, 10 patients dead and 1 patient lost to followup. So far we cannot draw a definite conclusion regarding the relationship between surgery and the prognosis of the patients because the followup period is too short in many patients. In our experience: 1) The fewest cancer deaths occurred in patients who had undergone radical surgery; 2) the largest percentage of living patients was seen in the group of patients who had undergone radical cystectomy; and, 3) almost all patients with low stage tumors are living more than 6 months after operation.
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