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Biomedical subjects

T Umeda

Publications and source records attributed to T Umeda.

At least 289 records · Page 16Linked to original sources
PubMed1984

Hepatic granuloma. Report of a case successfully treated by hepatectomy and antituberculous therapy.

A 62 year-old male presented with high fever, weight loss and painful hepatomegaly. The clinical presentation, results of laboratory studies, angiography and laparotomy suggested hepatic abscess or cholangiocarcinoma. He underwent left lobe hepatectomy, and pathological examinations revealed granuloma. Acid-fast bacilli, fungi and parasites were not identified by special stainings. Hepatic tuberculosis was considered most likely because, after operation, an intermediate-strength purified protein derivative (PPD) skin test gave strongly positive results and his subsequent response to antituberculous treatment was excellent. His complex clinical features and the diagnostic difficulties were outlined.

Antitubercular Agents↗
PubMed1984

Circulating immune complexes in patients with bladder cancer and other malignancies of the urogenital tract.

Sera from 70 patients with bladder cancer, 26 patients with kidney cancer, and 20 patients with prostate cancer were studied for the presence of circulating immune complexes (CIC) utilizing the human red blood cell (HRBC) radioimmunoassay. Elevated CIC levels were found in 32% of patients with bladder cancer, 30% of patients with kidney cancer, and 20% of patients with prostate cancer. For comparison, CIC was also measured in 37 sera from patients with bladder cancer by the polyethylene glycol precipitation complement consumption (PEG-CC) test. 13 of them (35%) had elevated CIC levels. The correlation between the results of the two tests was significant. There were significant correlations between CIC levels and the extent of tumor invasion and the degree of malignancy in patients with bladder cancer. The elevation of CIC level was also significantly associated with poor prognosis of these bladder cancer patients. It is proposed that measurement of CIC in patients with bladder cancer by the HRBC radioimmunoassay may be useful to evaluate their stage, degree of malignancy, and prognosis.

Adult↗
PubMed1984

Interrelation between plasma amino acid composition and growth hormone secretion in patients with liver cirrhosis.

We examined the possibility that abnormalities of growth hormone (GH) release in cirrhotic patients were related to a reduction in the ratio of branched chain amino acids (BCAAs) to aromatic amino acids (AAAs) in plasma. The intravenous infusion of 250 micrograms of thyrotropin-releasing hormone (TRH) caused a significant rise in plasma GH greater than 5 ng/ml and more than twice as much as the basal levels in 7 out of 15 patients (responders) but an insignificant rise in the remaining patients (non-responders). The difference in the basal GH level was not significant. The oral glucose load suppressed plasma GH in all of the normal subjects and 6 of 7 non-responders, while it was elevated in 6 of 7 responders and one of the non-responders. The ratio of BCAAs to AAAs in the plasma of cirrhotic patients was 1.21 +/- 0.38, which was significantly lower than that of normal subjects (3.31 +/- 0.42, p less than 0.01). In addition, there was a significant difference between responders and non-responders in the ratios (0.96 +/- 0.22 vs 1.42 +/- 0.36, p less than 0.05). An inversely significant correlation (p less than 0.05) between the ratios of BCAAs to AAAs in plasma and the peak levels of GH after TRH injection was observed when all subjects were combined, but no correlation was found between the ratios and the peak levels of GH after oral glucose loading. There were also significant correlations (p less than 0.01) between the ratios and various parameters including the serum albumin, cholinesterase and indocyanine green disappearance rate constant (KICG).(ABSTRACT TRUNCATED AT 250 WORDS)

Administration, Oral↗
PubMed1984

Abnormal blood chemistry data in Cushing's syndrome: comparison with those for fatty liver.

It has been reported that fatty liver is not uncommon in Cushing's syndrome. Biochemical data obtained from routine blood chemistry in 10 patients with Cushing's syndrome were compared with those for 15 patients with histologically verified fatty liver. We found an absence of a decreased GOT/GPT ratio, low normal choline esterase and increased lactic dehydrogenase activities together with lowered serum protein and albumin, and increased blood sugar and total cholesterol in Cushing's syndrome when compared with those of fatty liver cases. These data and additional findings in liver histology obtained from one patient with Cushing's syndrome due to adrenocortical carcinoma indicated that fatty changes in the liver were not frequently encountered in Cushing's syndrome. These abnormal biochemical data might be a way of distinguishing Cushing's syndrome from fatty liver.

Adult↗
PubMed1984

Hepatic dysfunction in primary hypothyroidism.

Twenty-seven patients with primary hypothyroidism were studied to evaluate the relationship between hepatic function and thyroid hormone deficiency in this disorder. In hypothyroidism, hypergammaglobulinemia was found in 71%, elevated glutamic oxaloacetic transaminase (GOT) in 48%, high lactic dehydrogenase (LDH) in 58%, hypercholesteremia in 52% and low elimination rate constant of indocyanin green (KICG) in 44%. In each criterion of liver function, these patients were divided into two groups, normal level and abnormal level group, respectively. T3 and T4 in patients with abnormal levels of GOT, glutamic pyruvic transaminase (GPT), gamma-glutamyl transpeptidase (gamma-GTP), leucine aminopeptidase (LAP), alkaline phosphatase (ALP) and 45 minutes retention rate of bromsulphalein (BSP) were not different from those in the normal level group. However, T3 and T4 in patients with abnormal levels of LDH, cholesterol, cholinesterase (ChE) and KICG were lower than those in the normal level group. The abnormal KICG group had a statistically higher cardio-thoracic ratio (CTR) than the normal group (65.7 +/- 18.8% vs 50.4 +/- 8.3%, p less than 0.05). In patients with pericardial effusion, CTR was 65.9 +/- 14.6%, while that in patients without pericardial effusion was 49.9 +/- 7.5% (p less than 0.05). These abnormalities of liver function were normalized in all cases after hormone replacement therapy. Liver biopsy in three cases disclosed normal liver in two cases and mild infiltration of monocyte into Glisson's capsule in one case.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1984

Changes of platelets, serum lactic dehydrogenase, gamma-glutamyltranspeptidase, choline esterase and creatine phosphokinase levels in patients with Cushing's syndrome.

In order to identify non-endocrine laboratory tests of diagnostic value in Cushing's syndrome, we measured platelet counts and serum myogenic and hepatic enzyme levels in 10 patients with Cushing's syndrome and compared the findings with those of 15 obese patients without Cushing's syndrome. Patients with Cushing's syndrome had increased numbers of platelets, moderately elevated serum lactic dehydrogenase and gamma-glutamyltranspeptidase levels, and significantly lower creatine phosphokinase and choline esterase activities compared with those of obese control patients. We concluded that when several of these abnormal values were seen in obese patients the levels of suspicion for Cushing's syndrome should be high.

Alanine Transaminase↗
PubMed1984

Decreased serum levels of various hydrolytic enzymes in patients with rheumatoid arthritis.

It is known that the serum level of glycylproline aminopeptidase (Gly-Pro-AP) is decreased in the patients with rheumatoid arthritis. In the present study, the serum levels of various hydrolytic enzymes were tested in such patients. In comparison to the controls, many enzymes, including Ala-AP, Ser-AP, Phe-AP, Gly-Pro-AP, Gly-Pro-Leu-AP, dipeptidyl carboxypeptidase (angiotensin converting enzyme), and esterase, showed significantly decreased activities in the patients' sera. Only the activity of Trp-AP was significantly increased. Of these enzymatic activities in serum, several ones including those of Gly-Pro-AP, Ala-AP, Phe-AP, trypsin-like enzyme, and esterase, were significantly correlated with the severity of the disease. Although a part of these findings are compatible with previous observations, they suggest rather more extensive disorders of peptide metabolism in this immunological disease.

Acetylcholinesterase↗
PubMed1984

Different tendencies of changes in hydrolytic enzyme activities in sera from prostatic cancer patients with or without bone metastasis.

Serum levels of various hydrolytic enzymes in prostatic cancer patients with or without bone metastasis were compared with those in patients with prostatic hypertrophy and in the control subjects. The enzymes tested included 11 aminopeptidases, 2 endopeptidases, dipeptidyl carboxypeptidase, esterase, acetyl cholinesterase, and RNase. Although most of the enzymatic levels tended to be decreased in the cancer patients without bone metastasis, they tended to be increased in those with metastasis as well as in the patients with prostatic hypertrophy. Thus, bone metastasis is an important factor affecting the serum levels of hydrolytic enzymes in cancer patients. Of the enzymes tested, RNase was unique in that its serum levels were significantly increased regardless of the existence of bone metastasis. This enzyme may become a marker of malignancy.

Aged↗
PubMed1984

[Leukocyte migration inhibition (LMI) of murine spleen cells after immunization with tumor cells, and an experimental study with LMI in combination therapy with a non-specific immunostimulant and a chemotherapeutic agent].

We have previously reported the leukocyte migration inhibition (LMI) factor in cancer patients, which is one of the specific parameters of cell mediated immunity. Since interpretation of these results was sometimes difficult in human cancer because of the unknown participation in the reaction, the inbred mouse strains were used as an experimental animal. We studied how the LMI factor of murine spleen cells changed with immunization of tumor cells, and intraperitoneal injection of protein polysaccharide (PSK) and/or cyclophosphamide (CPA). Method. LMI was performed by Clausen's method. Mouse strain; C3H/Heston. Tumors; C3M2 (methylcholanthrene induced tumor) and MAC (spontaneous mammary tumor). Result. Migration cells of murine spleen cells were almost granulocytes. Migration inhibition was maximum in 2 to 3 weeks after immunization of tumor cells. In vivo studies as well as in vitro studies revealed that C3M2 and MAC were not crossreactive. Migration was accelerated with CPA and inhibited with PSK. Leukocyte migration was inhibited by injection of PSK after treatment of CPA at a dose of 50 mg/kg, while in the case of CPA at a dose of 200 mg/kg, preinjection of PSK inhibited leukocyte migration.

Adjuvants, Immunologic↗
PubMed1984

Suppressive effect of cupric acetate on DNA alkylation, DNA synthesis and tumorigenesis in the liver of dimethylnitrosamine-treated rats.

The effect of cupric acetate on dimethylnitrosamine (DMN)-induced hepatocarcinogenesis in rats was investigated. The surviving rats in the group given DMN (25 ppm) in the drinking water alone were killed at 26 weeks and it was found that 12 of 16 rats had developed liver tumors. In the group given DMN and cupric acetate (sc injections of 2 mg of Cu/kg of body weight once a week for 26 weeks), 7 of 22 rats developed liver tumors. The incidence of liver tumors in rats given DMN and cupric acetate was thus only about 40% of that in rats given DMN alone. No tumor was observed in the group given saline or cupric acetate alone. The thymidine incorporation into the liver DNA of rats was measured at 2 and 4 weeks after the start of the carcinogenicity experiment. The thymidine incorporation into the liver DNA of rats given DMN was significantly suppressed by the administration of cupric acetate. The methylation of liver DNA in rats given a single dose of DMN was also significantly suppressed by sc injection of cupric acetate; the formation of both O6-methylguanine and 7-methylguanine was reduced. This result suggests that sc injection of cupric acetate may have a suppressive effect on the initiation of carcinogenesis in the liver.

Alkylation↗
PubMed1984

[Hemodynamic determinants of late systolic reversed flow in the main pulmonary artery in pulmonary hypertension: a pulsed Doppler echocardiographic study].

Pulsed Doppler echocardiograms of the main pulmonary artery were evaluated in 46 cases including 23 cases with valvular heart disease, 13 with an intracardiac shunt, two with severe right ventricular failure and low cardiac output state, and eight healthy normals. In each Doppler echocardiogram the sample volume was placed at well defined nine locations within the main pulmonary artery. Among 23 cases with valvular heart disease, 10 cases with pulmonary hypertension showed a late systolic reversed flow ("rebound" pattern : type B) in all nine sample volumes examined. This pattern was neither detected in any cases with normal pulmonary arterial pressure, cases with an intracardiac shunt, cases with low cardiac output state, nor healthy normals. A comparative study of 10 cases with "rebound" pattern (type B) and 13 cases without it disclosed that the former had a significantly increased pulmonary arterial pressure (30.9 + 15.1 mmHg vs 17.8 +/- 9.0 mmHg, p less than 0.001), an increased total pulmonary resistance (789 +/- 496 dynes X cm X sec-5 vs 285 +/- 170 dynes X cm X sec-5, p less than 0.001) and a decreased pulmonary arterial compliance expressed as stroke volume divided by pulmonary arterial pulse pressure (1.75 +/- 0.94 ml/mmHg vs 3.80 +/- 1.65 ml/mmHg, p less than 0.01). Mean acceleration of the pulmonary ejection expressed as peak flow velocity divided by acceleration period was also significantly larger in cases with "rebound" pattern (type B) than in cases with "normal" pattern (938 + 255 cm X sec2 vs 675 +/- 160 cm X sec2, p less than 0.01). In conclusion, "rebound" pattern (type B) in pulmonary hypertension is not simple swirl formation, but a totally reversed late systolic flow in the main pulmonary artery, which is caused by sudden interruption of the distal run-off due to markedly elevated total pulmonary resistance under normal right ventricular ejection.

Adolescent↗