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Biomedical subjects

T Ujiie

Publications and source records attributed to T Ujiie.

At least 37 records · Page 2Linked to original sources
PubMed1995

[Surgical treatment of acute aortic dissections--a clinical study using a ringed intraluminal graft].

From 1984 to 1994, surgery was performed using a ringed intraluminal graft (RIG) in 75 patients with acute aortic dissection (DeBakey's type I in 37 cases, type II in 10 cases and type III in 28 cases). The operative death rate was 24% for type I, 30% for type II and 21% for type III. The average time from onset to surgery was short (47 +/- 67 hours for type I, 34 +/- 36 hours for type II and 47 +/- 77 hours for type III). The outcome of these cases indicated that this technique was effective for saving the lives of patients in the acute early stage of aortic dissection. No characteristic complications developed after this surgery. The postoperative course of patients was followed by using CT scans, MRI, angiography. No patients developed aneurysmal formation in the ligated area or dislocation of the RIG. There were no deaths directly attributable to the RIG. Patients who were autopsied in the late postoperative period showed no aneurysm of the ligated area or necrosis of the aortic wall. In conclusion, RIG surgery effectively saved the life of patients with acute aortic dissection and the RIG could be used as prosthetic graft for long-term periods.

Acute Disease↗
PubMed1994

Eating Attitudes Test in Japan.

A Japanese version of the Eating Attitudes Test (EAT) was developed and validated using a group of anorectics and Japanese female controls. Its sensitivity was considered to be low for anorectics, especially for the fasting type anorectics. A cross-cultural comparison of the EAT scores of anorectics showed some significant differences among those found in Japan, Canada and Germany. A survey of eating disorders among 286 Japanese female students was carried out with a Japanese EAT. Three cases of bulimia nervosa were identified in this survey, although no clear case of anorexia nervosa could be identified. The EAT seemed to be useful to screen cases of bulimia nervosa and sensitive to distinguish abnormal eating attitudes among the young females in Japan.

Adult↗
PubMed1994

[A case report of left ventricular-right atrial communication with tricuspid regurgitation due to infective endocarditis].

A case of 58-year-old man with a left ventricular-right atrial communication with tricuspid regurgitation due to infective endocarditis was reported. Surgical treatment was performed following intensive chemotherapy. The communication was found in the center of a vegetation on the septal leaflet. Closure of the communication and replacement of the tricuspid valve were done successfully. His postoperative course was uneventful.

Endocarditis, Bacterial↗
PubMed1993

[An investigation of medical circumstances of the long-term hospitalized severely mentally and physically handicapped children in Sapporo district].

The author investigated medical circumstances of the severely mentally and physically handicapped children who needed to be treated for more than one month at general hospitals in Sapporo district using a questionnaire method followed by a direct observation. Fifty patients were identified and their chronological ages distributed from 5 months to 19 years old. The mean period of hospitalization was approximately 2 years. They could be roughly divided into two groups; high risk infants for severely mental and physical handicap; and the most severely mentally and physically handicapped teens needing hospital treatment for their lives. Etiology was congenital in 38% (CNS malformations, neuromuscular diseases, etc.), acquired in 36% (hypoxic brain damage due to accidents, CNS infections, etc.) and perinatal in 26% (all hypoxic ischemic encephalopathies). More than 90% of the patients showed abnormal brain CT scan and 20% had visual and/or auditory disturbances. A half of them needed artificial ventilation supports and/or tracheal cannulation. More than 60% received tube feeding therapies. From this evidence, it is considered that the long term hospitalized severely mentally and physically handicapped children have severe brain dysfunction which needs high medical technology and professionals. It seems that a little remedial supports to them is done in general hospitals at present in Sapporo district. Comprehensive treatment will hopefully be done for them in the near future.

Adolescent↗
PubMed1993

[Endoscopic correction of vesicoureteral reflux by Teflon].

From March 1988, 19 vesicoureteral reflux (VUR) patients were treated by endoscopic injection of Teflon paste. Of these patients 17 cases 27 ureters were followed for more than one year. After injection of Teflon paste, reflux was eliminated in 63%, decreased in 30%, and unchanged in 7%. Then 7 ureters were injected twice and 1 ureter three times. Finally, reflux was eliminated in 93% of all cases, and decreased in 7%. Early complications were fever up in 4 cases, flank pain 3, acute cystitis 1. In the follow up period, acute cystitis occurred in 1 patient, ureter stone in 1, and renal failure in 1. However, the ureter stone and renal failure were probably not caused by this procedure.

Adult↗
PubMed1992

[Clinical statistics of the Urological Clinic of Sapporo Sanjukai Hospital. Clinical statistics on patients admitted from 1985 to 1989].

A clinical statistic survey was carried out on the patient admitted, diseases and operations experienced at our urological clinic during 1985-1989. The total number of inpatients was 8,750 (The male to female ratio was 2.8:1). The major diseases of the inpatients were urolithiasis (4,134 cases, 47.2%) and benign prostatic hypertrophy (1,529 cases, 17.5%). Among the operations extracorporeal shock-wave lithotripsy 2,589 cases (44.6%) and transurethral resection of prostate 1,295 cases (22.3%) were predominant.

Adolescent↗
PubMed1992

[Sarcomatoid renal cell carcinoma: 3 case reports].

We report 3 cases of sarcomatoid renal cell carcinoma, which is an uncommon neoplasm consisting of a typical renal cell carcinoma associated intimately with a sarcomatoid component. All patients were symptomatic at hospitalization and underwent nephrectomy. Two patients died of metastatic renal cancer within a year, and another is alive without evidence of metastasis for 12 months after the surgery. Because sarcomatoid renal cell carcinoma has a highly malignant behavior and poor prognosis, an adjuvant treatment effective in controlling the disease is awaited.

Adult↗
PubMed1991

[Clinical application of Modulith SL20 on extracorporeal shock wave lithotripsy for upper urinary tract calculi].

Thirty-nine patients, 27 males and 12 females with renal and ureteral stones, were treated using the Modulith SL 20 between October 1990 and January 1991. Thirty-three of the 39 cases had a single session of extracorporeal shockwave lithotripsy (ESWL) and the other six cases had two sessions. The pulverization rate of ESWL by this device was 84.6%. According to the X-rays taken 21 days after ESWL, of the 37 cases, 14 (37.8%) were stone-free, 18 (48.7%) had residual sandy stones less than 4 mm in diameter, five (13.5%) had residual stone fragments larger than 4.1 mm in diameter, and two cases were not clear. Using the criterion of cases which can be expected to have spontaneous passage, in other words, residual stones less than 4 mm in diameter, lithotripsy with the Modulith SL 20 was regarded as "effective" in 32 of the 37 cases (86.5%). As side effects of this treatment, hematuria was observed for several days after ESWL in all patients, but not other serious complications were observed. Among the 37 cases in which the grade could be evaluated the evaluation for 24 (64.9%) was "useful" and that for 13 (35.1%) "useful to some extent". Therefore, ESWL was performed very successfully.

Adult↗
PubMed1990

[Clinical study on recurrence of urinary tract lithiasis of ESWL].

During the 4 year period from September 1, 1984 through August 31, 1988, a total of 1,866 patients with calculi of the urinary tract (125 patients had bilateral calculi) were subjected to extracorporeal shock wave lithotripsy (ESWL) with a DORNIER HM3 ESWL apparatus. Follow-up was performed factor 1,056 cases 3 or more months after complete elimination of the calculi, and data were obtained for 343 of them. Lithiasis was found to have recurred after ESWL in 30 cases, with a recurrence rate of 11.1%. Recurrence was seen in 16.9% of cases with multiple calculi and 6.5% of cases with a single calculus. The difference was statistically significant. Surgical removed of calculi or spontaneous discharge of calculi had been experienced in 50.0% of the recurrent cases and 27.8% of the non recurrent cases. The difference was also statistically significant. Stone size, stone location and urinary tract infection were unrelated to the recurrence.

Adult↗
PubMed1989

Prostatic epithelial polyp of the prostatic urethra.

Ten cases of prostatic epithelial polyps of the prostatic urethra are reported. The ages of the patients were from 27 to 69 years, with a mean of 44 years. The most common clinical signs were gross hematuria, microhematuria, hematospermia, and dysuria. All specimens, obtained by transurethral resection, had a papillary or polypoid configuration. The tissue had a glandular structure that resembled that of the prostate. Prostate-specific antigen and prostatic acid phosphatase were found in the epithelial cells of the polyps by indirect immunoperoxidase staining. The polyps seemed to be hyperplasia of prostate-specific antigen and prostatic acid phosphatase-positive epithelial cells of the prostatic gland or duct, especially that of the latter.

Adult↗
PubMed1989

[Metastatic renal tumor of esophageal carcinoma: report of a case].

In August 1987, a 66-year-old man was hospitalized because of macrohematuria and right flank pain. He had undergone resection of middle and lower part of the esophagus with esophagogastrostomy for esophageal carcinoma on April 16, 1984. Computed tomography revealed a solid, irregular, low density area in the upper pole of the right kidney and the right lobe of the liver. Arteriography showed a hypovascular mass in the upper pole of the right kidney, and several small tumor stains in the liver. At cystoscopic examination, the urinary bladder was normal and blood flowing from bilateral ureters was not seen. Cytological study of urine sediment disclosed squamous cell carcinoma. The patient was treated with systemic chemotherapy, but not improved. He died 6 months later, and the autopsy demonstrated widespread metastasis in various organs including the right kidney and liver. No recurrence was found in the residual esophagus. The kidney is the sixth organ of metastasis following the lung, liver, bone, adrenal, peritoneum and mesenterium. Although metastasis to the kidney is relatively common in autopsy, it is uncommon to be manifest clinically.

Aged↗
PubMed1989

Increased sensitivity of tumor cells to immune defense cells following treatment with antineoplastic agents in vitro.

Murine EL-4 thymoma cells became highly sensitive to attack by cytotoxic T-lymphocytes (CTL) and allo-reactive T-cells in a 4-hr 51Cr release assay when the target EL-4 cells had been either incubated with 5-fluorouracil, cytosine arabinoside or hydroxyurea at 37 degrees C for 16 hr (nearly one generation period), or exposed for 30 min to adriamycin, actinomycin D, bleomycin, mitomycin C, 1-(4-amino-2-methylpyrimidine-5-yl)-methyl-3-(2-chloroethyl)-3-nitros our ea, cis-diamminedichloroplatinum(II) or 4-hydroperoxycyclophosphamide followed by incubation for 16 hr. In contrast, short-term exposure of EL-4 cells to the latter group of drugs had no effects on immune lysis in vitro. Target cells treated with these antineoplastic agents were enlarged in volume, resulting from the blockade of cell division, and the major histocompatibility complex (MHC) class I antigens detectable on the cell surface were significantly increased in the treated cells. CTL can lyse altered cells by recognizing foreign antigens in association with MHC class I antigens. Thus, these data suggest that the enhanced sensitivity of target tumor cells to CTL lysis following treatment with antineoplastic agents could be at least partly due to increases in the expression of MHC class I antigens. These treatments made natural killer (NK)-resistant EL-4 cells susceptible to NK lysis, hence, their relation to chemoimmunotherapy for cancer is discussed.

Animals↗
PubMed1989

[Clinical statistics on outpatients at the urological clinic of Sanjukai Hospital in 1988].

A statistical study was performed on new outpatients. The total number of new outpatients in 1988 was 8,389 (male: 5,284, female: 3,105) and the male to female ratio was 1.70:1. They had urogenital diseases definitely diagnosed (7,486), urogenital diseases indefinitely diagnosed (576), no diseases (260), and diseases other than urogenital (67). Thirty-five percent of the outpatients were referred to us by other sources. The number of operations on new outpatients was 139, circumcision, vasectomy and resection of condyloma were representative. The peak of the age distribution was in the thirties for males and in the fifties for females. A statistical study was made on new outpatients according to the international classification of disease. There were 146 malignant (urogenital) tumors (1.8%). The major diseases of the new outpatients were cystitis (acute or chronic: 20.7%), upper urinary tract stone (18.5%), prostatitis (13.0%), and benign prostatic hypertrophy (11.2%). In males the major diseases were prostatitis, upper urinary tract stone, benign prostatic hypertrophy, balanoposthitis, phimosis and in females they were cystitis, upper urinary tract stone, pyelonephritis, renoptosis, and neurogenic bladder. We conclude that our hospital plays a major role as a private urological hospital.

Adult↗
PubMed1988

Ceroid-lipofuscinosis. Report of two autopsy cases.

Light and electron microscopic examinations were performed on two autopsy cases of ceroid-lipofuscinosis of the juvenile (Case 1) and late infantile (Case 2) types. Much ceroid-lipofuscin (CL) was found in nerve cells throughout the nervous system. In Case 1, CL had also accumulated in thyroid follicular cells, glomerular podocytes, and epithelial cells of the ductus epididymidis, and in the endothelium and smooth muscle of vessels. Electron microscopy showed CL in 5% of peripheral lymphocytes sampled when the patient was alive. In Case 2, an accumulation of CL was found in the vascular endothelial cells of the cerebrum, and Kupffer cells and sinusoidal endothelial cells of the liver. The CL was autofluorescent, and was seen to be composed of electron-dense granules, lipid droplets, lamellar structures, and curvilinear bodies by electron microscopy. Limiting membranes were often found surrounding CL granules. The dolichol level in the cerebral cortex was high in Case 1. Accumulation of CL was found in cells other than nerve cells, although the main signs and symptoms were caused by the involvement of nerve cells. The CL showed various ultrastructural features.

Adult↗
PubMed1988

Immunogenic potential of tumor cells after treatment with antitumor chemotherapeutic agents.

Mouse EL-4 lymphoma cells exposed in vitro for short periods to 4-hydroperoxycyclophosphamide, an in vitro active derivative of cyclophosphamide, and to another alkylating agent, cis-diamminedichloroplatinum(II), as well as to mitomycin C, induced development of antitumor immunity in syngeneic mice co-administered with OK-432, an immunostimulator prepared from streptococci. The anthracyclines (adriamycin and daunomycin) were very slightly effective. The efficacy of the alkylating agents in inducing tumor immunity was also demonstrated by their ability to stimulate secondary in vitro generation of splenic cytotoxicity. These data supported the proposed explanation for effectiveness of chemoimmunotherapy against poorly immunogenic tumors.

Adjuvants, Immunologic↗
PubMed1988

[Studies on serum and urinary alpha 1-microglobulin levels as parameter of the renal function--renal function observed after CDDP administration].

To evaluate the clinical usefulness of alpha 1-microglobulin (alpha 1-MG) as parameter of renal function, we determined the levels of alpha 1-MG in the serum and urine of patients who had no malignant tumors, and compared them with the levels of beta 2-microglobulin (beta 2-MG), serum creatinine, urinary N-acetyl-beta-glucosaminidase (NAG) and 24-hour creatinine clearance (24 Ccr). There were significant positive correlations between alpha 1-MG in the serum and urine, and those of beta 2-MG levels. Serum alpha 1-MG and 24 Ccr were inversely correlated. Combined measurements of alpha 1-MG in the serum and urine seemed to be useful to estimate glomerular and tubular renal functions. The renal function in 8 patients with advanced urogenital cancers treated with cis-diammine-dichloroplatinum (CDDP) was examined by measuring 24 Ccr, alpha 1-MG, and beta 2-MG in serum and urine and urinary NAG. Determination of urinary alpha 1-MG was useful for early detection of tubular damage after CDDP administration.

Acetylglucosaminidase↗