Search PubMed⌕ Search

Biomedical subjects

T Tsutsui

Publications and source records attributed to T Tsutsui.

At least 343 records · Page 19Linked to original sources
PubMed1982

Ga-67 scan in patients with intrathoracic esophageal carcinoma planned for surgery.

The authors evaluated Ga-67 scan in 68 patients with intrathoracic esophageal carcinoma initially planned for surgery. Of these, 59 patients were staged pathologically or surgically; their Ga-67 scan results correctly predicted the presence of extraesophageal spread and lymph node metastases. Of 38 clinical Stage II patients, 15 (39%) could be Stage III by the results of Ga-67 scan. However, two of four clinical Stage I patients (50%) and 35 of 38 clinical Stage II patients (92%) were eventually pathologic or surgical Stage III. This high conversion rate and the high incidence of Stage III in esophageal carcinoma patients may not justify routine use of Ga-67 scan only for staging. Ga-67 scan, however, was useful for planning radiotherapy, because missing extraesophageal extension or gross metastases from the radiation fields were detected in six patients of 51 so treated. Ga-67 scan has its value in some patients with intrathoracic esophageal carcinoma.

Esophageal Neoplasms↗
PubMed1982

Serial observations of brain stem function by auditory brain stem responses in central transtentorial herniation.

Changes in auditory brain stem responses were serially investigated in a patient with downward transtentorial herniation due to acute obstructive hydrocephalus to correlate the neurological signs with the results of computerized tomography. Neurological deterioration correlated highly with disruption of auditory brain stem responses, especially with that of the components of waves V to VII. A noninvasive technique, the measurement of auditory brain stem responses is thought to be useful in detecting the severity of downward transtentorial herniation and in estimating the recovery of brain stem function after surgical treatment of intracranial hypertension.

Brain Stem↗
PubMed1982

Computerized tomography of the brain in manic-depressive patients--a controlled study.

A computerized tomography (CT) of the brain was carried out on 40 manic-depressive patients and 40 controls in order to study the organic characteristics of the brain in manic-depressive psychosis. In the age group of 49 years and below, the left septum-caudate distance (LSC) showed a lower value in the manic-depressive group, but the other measurements for the ventricular system did not differ between both groups. The age group of 50 and over revealed a significant enlargement of maximum width of the interhemispheric fissure (IF) and maximum width between the sylvian fissure and inner skull (SFIS) in the manic-depressive group compared with the controls. The tendency to an enlargement of the third ventricle (HIV) and maximum width of the right anterior horn (RAH) was also seen in the manic-depressive patients. Cortical atrophy tended to appear in the temporal and occipital lobes earlier in the manic-depressive group than in the controls. The patients showing a cerebral asymmetry of the hemisphere in the manic-depressive group tended to show a reversed cerebral asymmetry.

Adolescent↗
PubMed1982

Open versus closed position fixation of bioprosthesis. Comparative in vitro studies from the viewpoint of durability.

In an effort to normalize the dynamic leaflet behavior of a porcine bioprosthesis, an experimental attempt was made to treat a tissue heart valve with 0.625% glutaraldehyde in the open position ("open-type valve"). Eighteen open-type valves, having fixed openings of various sizes, were examined with our pulse simulators. Eight closed-type valves, which were treated in the closed position, were studied for comparison. The results showed that closed-type valve tended to offer an immobile cusp at a low flow state; at a pump pressure of 90 mm Hg in a pulsatile flow or under steady flows of no more than 10 L/min. By contrast, the open-type valve showed the symmetric cusps opening with circular orifices at any given flow rates. Analysis of the pressure loss coefficient revealed that the leaflets prepared in the open position produced only a minimal impediment to the forward flow. One half of the anatomic orifice of a valve was considered to be the optimal size for the fixed opening. It is concluded that open position fixation is expected to provide the bioprosthesis with improved fatigue durability in patients with low cardiac output syndrome and in small children.

Aortic Valve↗
PubMed1981

Comparison between mutagenesis in normal and transformed Syrian hamster fibroblasts: difference in the temporal order of HPRT gene replication.

A highly tumorigenic subdiploid cell line, BP6T, derived in our laboratory from Syrian hamster embryo (SHE) cells, is amenable to studies of somatic mutation in vitro. Cellular and biochemical characterization of clonally derived BP6T cells resistant to 6-thioguanine (TGr) or ouabain (Quar) demonstrated these mutants to be similar qualitatively to mutants of SHE cells characterized previously (Barrett et al., 1978). BP6T TGr mutants resistant to 6-thioguanine are cross-resistant to 8-azaguanine, lack HPRT activity, exhibit a low frequency of reversion and arise spontaneously at a rate of approximately 5 X 10(-7) mutants per cell per generation. BP6T Ouar mutants were shown to be highly resistant to ouabain-mediated inhibition of 86Rb influx, indicating an alteration in the Na+/K+ ATPase. These studies on the BP6T cell line provide the experimental basis for a comparative study of the mutagenic responses of normal, diploid SHE cells versus those of related, but transformed aneuploid cells. Highly synchronized cultures of these 2 cells were mutagenized by pulse treatment with BrdU during different periods of S phase, followed immediately by near-UV irradiation. The induced mutation frequencies so obtained provided information about the temporal order of replication of genes encoding HPRT and Na+/K+ ATPase in both SHE and BP6T cells. The temporal pattern of replication of Na+/K+ ATPase gene loci is similar in both cell types, but the temporal order of replication of the HPRT gene is significantly different between SHE and BP6T cells (mid-late S phase, versus early S phase, resp.). This observed difference emphasizes the caution required in the study of mutagenesis and DNA replication using transformed, aneuploid cells under the assumption that the underlying mechanisms are the same for normal, diploid cells.

Animals↗