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Biomedical subjects

T Tsuchiya

Publications and source records attributed to T Tsuchiya.

1,024 records · Page 57Linked to original sources
PubMedDate not supplied

A case of solitary tuberculosis of the liver.

The liver involvement by tuberculosis in the macronodular form is quite rare and one must know their clinical features and actual imaging to have precise diagnosis. We present a case of the solitary hepatic tuberculosis, of which angiographic findings originally suggested hepatocellular carcinoma (HCC) given Lipiodol Ultra Fluid (LUF). On angiogram the tuberculoma showed marked hypervascularity in a capillary phase. Histological examination of the biopsy specimen disclosed granulomas with central coagulation necrosis. A good clinical response was achieved with a course of Isoniazid and Rifampicin. Angiographic findings of one year later showed hypovascularity. Meanwhile LUF remained long in the tuberculoma marginally, presenting nodular opacities on lipiodolized CT. This finding was different from that of HCC. We also discussed those clinical actual imaging and pathological findings.

Adult↗
PubMedDate not supplied

Left atrial myxoma presenting as acute myocardial infarction.

A 58-year-old man with left atrial myxoma complicated with acute myocardial infarction is presented. On coronary arteriography, 50% stenosis and a saccular aneurysm was found just below the stenosis at segment 1 of the right coronary artery. Ergonovine provocation study was negative. It was proposed that the myocardial infarction probably was caused by coronary embolization from the left atrial myxoma.

Coronary Aneurysm↗
PubMedDate not supplied

Pancoast tumour treated with combined radiotherapy and hyperthermia--a preliminary study.

Six patients with Pancoast (superior sulcus) tumours were treated with combined radiotherapy and hyperthermia from April 1986 to December 1989. Radiotherapy was performed using 10 MV X-ray, and all patients received total doses of 60-74 Gy, in five fractions per week, during 5.5-15 weeks. Hyperthermia was performed once or twice a week within 30 min after each irradiation, using 8 MHz RF capacitive heating equipment (Thermotron RF-8). Partial response, defined as 50% or more regression of the tumour, was observed in four of the six patients. Three patients are alive 30, 28, and 14 months after their treatments. Radiotherapy combined with hyperthermia appears to be a promising and effective means for treating Pancoast tumours.

Adenocarcinoma↗
PubMedDate not supplied

Overview of clinical studies of childhood acute lymphoblastic leukemia for more than ten years by the Japanese Children's Cancer and Leukemia Study Group.

Since 1981, the Children's Cancer and Leukemia Study Group (CCLSG) has developed a series of protocols for treatment of acute lymphoblastic leukemia (ALL) in childhood. In the first randomized controlled study of the 811 protocol (1981-1983) a comparison of conventional daily 6-mercaptopurine and methotrexate with a pulsed regimen of the two drugs was performed. The superiority of the pulsed regimen was shown. In the next 841 protocol (1984-1987) a comparison of two drugs and three drugs during induction therapy was conducted. The three-drug regimen resulted in a significantly higher event-free survival (EFS) rate. In the 874 protocol (1987-1990) two regimens with or without cranial irradiation were randomly compared, and there was no significant difference between the two regimens for the standard-risk group. To further improve the EFS rate a risk group-directed protocol 911 was conducted starting in January 1991. Life-table analysis of serial CCLSG protocols revealed that the outcome of overall ALL has gradually improved with an increase of the EFS rate; 41.4% +/- 3.6% at 14 years for the 811 protocol, 51.3% +/- 3.5% at 11 years for the 841 protocol, 56.7% +/- 3.1% at 8 years for the 874 protocol, and 78.2% +/- 3.1% at 4 years for the more recent 911 protocol.

Antineoplastic Combined Chemotherapy Protocols↗
PubMedDate not supplied

Rearrangements of bcl-1, bcl-2, bcl-6, and c-myc in diffuse large B-cell lymphomas.

Diffuse large B-cell lymphoma (DLBL) is characterized by a marked degree of morphologic and clinical heterogeneity. We studied 137 patients with de novo DLBL for rearrangements of the bcl-1, bcl-2, bcl-6 and c-myc oncogenes by Southern blot analysis. Structural alterations of bcl-1, bcl-2, bcl-6, and c-myc were detected in 21 of 137 (15.3%), 8 of 137 (5.8%), 22 of 137 (16.1%), 14 of 137 (10.2%) patients, respectively. Two cases showed a combination of bcl-1 and bcl-6 rearrangements. Chromosomal analysis was performed in 31 cases of the 137 DLBL. 27 of these showed karyotypic abnormalities, and two had translocations 3q27 involving bcl-6. However, one of two cases had no rearrangement of bcl-6. Patients with rearranged bcl-6 and c-myc tended to have poorer survival than patients with germ-line. Furthermore, bcl-1 and bcl-2 rearrangements tended to have a better outcome, although the above differences were not statistically significant. Rearrangements of the bcl-1, 2, 6, and c-myc gene correlated with the clinical outcome in DLBL and may thus serve as prognostic markers in patients with this form of malignant lymphoma. However, other genetic factors are probably involved in determining prognosis.

Adolescent↗
PubMedDate not supplied

Cephalometric changes during self-correction of primary anterior crossbite.

Longitudinal growth changes were investigated cephalometrically for sixty-one Japanese girls who had anterior crossbite at the initial visit (ages 3 years and 11 months on an average). Cephalograms were taken annually from the initial visit to the end of the observation period (ages 7 years 6 months on an average). Eleven of them (Group N1) showed self-correction of anterior crossbite during the primary dentition; ten (Group N2) showed self-correction when the permanent incisors erupted and forty (Group R) did not show self-correction. There was no statistical skeletal difference between Groups N1 and N2 during the observation period. Groups N1 and N2 were larger, however, than Group R in A'-Ptm'/Pog'-Go (p < 0.05) and Group N1 was smaller than Group R in Pog'-Go/N-S (p < 0.01) at the end of the observation period. In summary, favorable growth of the maxilla relative to the mandible leads to self-correction of primary crossbite and when mandible size relative to the cranial base is large, primary crossbite does not show self-correction.

Analysis of Variance↗
PubMedDate not supplied

Effect of sealant viscosity on the penetration of resin into etched human enamel.

This study was designed to investigate the relationship between the etched depth, penetration of sealants and marginal seal. Sixty unerupted lower first premolars extracted from patients for orthodontic reasons were thoroughly cleaned and stored in an antiseptic Ringer's solution at 4 degrees C. A "window" on the occlusal of 15 of the premolars, including both mesial and distal pits, was developed by painting nail varnish around the border of the occlusal surfaces. Etching was then done with 35% phosphoric acid for 60 seconds to all 60 premolars. Five of the "window" teeth were evaluated by microradiography to determine the etched depth of the superficial and subsurface enamel. Five were prepared for SEM analysis to observe the change of the superficial etched enamel surface. Another five "window" teeth were embedded in epoxy resin and sectioned parallel to the long axis of the tooth through the fissures in order to observe the subsurface depth of the etch by SEM analysis. The other 45 teeth were divided into three groups of 15 teeth each. Fissures of each group of teeth were sealed using Prisma-Shield (LD Caulk), Concise White Sealant (3M Dental Products) or Teethmate A (Kuraray) sealants and stored in water (37 degrees C) for 24 hours. They were then sectioned and demineralized before being examined by a scanning electron microscope. Photographs of secondary electron image (SEI) were done to gradate the resin-infiltrated enamel and resin tags for these sealants. After SEM observation, the 15 samples of each applied sealant were polished to a high gloss again and placed in a silver nitrate solution for 24 hours before being examined under the SEM equipped with a back-scatter electron detector. Data were then analyzed using the Welch and Student t-tests. Results showed that fissured enamel of unerupted human lower first premolars became porous after etching with 35% phosphoric acid. The low viscosity sealant Teethmate A (approximately 260 mPa.s), penetrated fully and formed a resin-infiltrated layer in enamel beyond the etched depth. However, the high viscosity sealants (Prisma-Shield and Concise White Sealant) did not penetrate enough to ensure that the acid-etched enamel was infiltrated sufficiently by the sealant to insure good marginal seals.

Acid Etching, Dental↗
PubMedDate not supplied

Clinical application of low calcium peritoneal dialysate.

Low calcium dialysate (LCa) with calcium levels of 2.3 mEq/L was prepared for peritoneal dialysis, and its equilibration was compared with those of conventional dialysates with calcium contents of 3.5 mEq/L and 4.0 mEq/L. The variation in dialysate to plasma concentration ratios of total calcium of conventional dialysates was positive; that of LCa was negative. Mass transfer of calcium per day was positive and normal for calciums of 4.0 mEq/L (31 +/- 51 mg/day) and 3.5 mEq/L (-37 +/- 40 mg/day), compared with a negative balance for LCa (-157 +/- 26 mg/day). The LCa was used in six patients over 6 months. The doses of calcium carbonate and vitamin D also were increased from 1.2 +/- 1.5 to 5.4 +/- 3.3 g/day (p less than 0.05) and from 0.17 +/- 0.2 to 0.38 +/- 0.47 micrograms/day, respectively. Aluminum gel was discontinued. Low calcium dialysate may become the standard dialysate for stable continuous ambulatory peritoneal dialysis patients.

Adult↗
PubMedDate not supplied

Imaging of the basal cerebral arteries and measurement of blood velocity in adults by using transcranial real-time color flow Doppler sonography.

We report an attempt to obtain images of the basal cerebral arteries and to measure the quantitative flow velocity in these arteries from outside the skull via the color Doppler imaging method. In 25 healthy volunteers, 22-41 years old, the transducer was positioned just superior to the zygomatic arch and anterior to the external ear canal. The absolute flow velocity was calculated by dividing the measured velocity by the cosine of the incident angle. The middle cerebral artery was readily identified in all subjects, but the anterior cerebral artery was seen in only 7/50, and the posterior cerebral artery in 27/50. The corrected mean velocity of the horizontal middle cerebral artery was 86 +/- 17 cm/sec at an average incident angle of 49 degrees. However, it was difficult to calculate the absolute flow velocity in the anterior and posterior cerebral arteries because the length of those arteries delineated was too short to read the incident angle. The reproducibility of the mean blood velocity in the middle cerebral artery was tested by two examiners on two different occasions, and showed a linear regression with a correlation coefficient of 0.93 (p less than .001) when the correction with the incident angle was made. Transcranial real-time color-flow Doppler imaging permits more accurate noninvasive quantification of cerebral hemodynamic consequences than previous methods do.

Adult↗
PubMedDate not supplied

Temporary liver support using a new type of sorbent. A urethane sheet embedded with powdered charcoal.

A new sorbent, urethane sheet embedded with powdered charcoal (UPC, BESPORE), which had been developed for use in a temporary liver support system, has been clinically applied since 1984. This system consists of a UPC plasma-perfusion circuit (using a recirculation system) followed by a supplementary 0.8 L plasma exchange, using hemodialysis for the purpose of performing both removal and supplementary therapy at the same time. On average, approximately 40% of both bilirubin and bile acid are removed, with the osmolality gap reduced by 30%. This system is effective for prolongation of life in patients with chronic hepatic failure and those with acute hepatic failure that has become chronic. It can be considered an effective maintenance therapy for patients before liver transplantation.

Adsorption↗
PubMedDate not supplied

[Effect of reperfusion therapy on the prognosis of acute myocardial infarction complicated by left heart failure: prediction based on the acute course of left ventricular heart failure].

This study evaluated the correlation between the acute course and prognosis of patients with acute myocardial infarction complicated by heart failure. Heart failure was defined as a mean pulmonary capillary wedge pressure equal to or greater than 20 mmHg with radiographic evidence of pulmonary congestion during hospitalization in the coronary care unit. A total of 77 heart failure patients underwent primary percutaneous transluminal coronary angioplasty or thrombolysis. Twelve patients who died within the first 3 days (group I) had a higher incidence of unsuccessful reperfusion (50 vs 19%, p < 0.05) and cardiogenic shock (64 vs 4%, p < 0.01), compared with the 65 patients who survived at least the initial 4 days (group II). These 65 patients were classified into three subgroups according to the course of heart failure: early regression type (group IIA, n = 38); prolonged type (group IIB, n = 18); delayed-onset type (group IIC, n = 9). Patients in group IIB had a higher incidence of multivessel disease than group IIA. Patients in group IIC had a higher incidence of unsuccessful reperfusion. Cardiac index in group IIB was lower than in group IIA (2.50 +/- 0.70 vs 1.91 +/- 0.39 l/min/m2). Changes in left ventricular ejection fraction were 4.1 +/- 9.2% in group IIA, -6.6 +/- 16.8% in group IIB, and 0.9 +/- 7.3% in group IIC. The hospital mortality rate was 0% in group IIA, 11% in group IIB, and 33% in group IIC, the reinfarction rate was 0, 17 and 22%, and sustained arterial patency was demonstrated in 81, 62 and 43%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗