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Biomedical subjects

T Tsuchiya

Publications and source records attributed to T Tsuchiya.

At least 703 records · Page 39Linked to original sources
PubMed1984

Inhibitory effect of Li+ on cell growth and pyruvate kinase activity of Escherichia coli.

Li+ inhibited growth of Escherichia coli when glucose, galactose, fructose, or glycerol was added as the sole source of carbon. Growth inhibition was not observed when lactate or a mixture of amino acids was used as the carbon source. A mutant possessing elevated activity of Li+ extrusion was not inhibited by Li+. These results suggested that intracellular Li+ inhibited the glycolytic pathway, most likely triose metabolism, without affecting gluconeogenesis. We also found that pyruvate kinase I was inhibited by Li+.

Cations, Monovalent↗
PubMed1984

Immunocytochemical study on the C cells in pig thyroid glands.

The distribution of pig thyroid C cells was demonstrated by a immunoperoxidase method using antiserum to porcine calcitonin. The average number of C cells per 4 mm2 counted in the deep and superficial regions was 127 and 55, respectively. The number in the cranial, middle and caudal regions was 60, 128 and 83, respectively. The number of C cells per follicular and C cells (C cell concentration) in deep and superficial regions was 4.9 and 2.6%. It was 3.2, 4.9 and 3.3% in the cranial, middle and caudal regions, respectively. These results indicate that the number and concentration of C cells were not only larger in deep than superficial regions but also in the middle region than in cranial and caudal in pig thyroid gland. These results also indicate that the C cell distribution in pig thyroid gland is the same as that of dog, human, cat, rat, guinea pig, and mouse.

Animals↗
PubMed1984

A case of cornstarch granuloma.

A 57-year-old female was diagnosed as having asymptomatic cornstarch granuloma. The disseminated small nodules over the peritoneum were incidentally discovered at operation for cholelithiasis, when she was misdiagnosed as carcinomatosis peritonei. Histological observations revealed a characteristic finding of tuberculoid granuloma with caseous necrosis, a rather rare histological type of cornstarch granuloma. Polarized light microscopic examination of biopsy specimens is particularly important for the diagnosis. We emphasize that cornstarch granuloma should once be considered when tuberculoid or unknown abdominal granuloma are observed in patients with history of abdominal surgery.

Female↗
PubMed1984

A radiation detector fabricated from silicon photodiode.

A silicon photodiode is converted to a low energy charged particle radiation detector. The window thickness of the fabricated detector is evaluated to be 50 micrograms/cm2. The area of the depletion region is 13.2 mm2 and the depth of it is estimated to be about 100 microns. The energy resolution (FWHM) is 14.5 ke V for alpha-particles from 241Am and 2.5 ke V for conversion electrons from 109Cd, respectively.

Alpha Particles↗
PubMed1984

Syntheses of 23-deoxy-23-N-ethyl-23-(2-fluoro-, 2,2-difluoro-, and 2,2,2-trifluoroethyl)amino derivatives of mycaminosyl tylonolide and 4'-deoxymycaminosyl tylonolide.

Derivatives of mycaminosyl tylonolide (1) and 4'-deoxymycaminosyl tylonolide (2) containing N-ethyl-2-fluoro-, 2,2-difluoro- and 2,2,2-trifluoroethylamino groups at their C-23 have been prepared by treating 23-deoxy-23-ethylaminomycaminosyl tylonolide diethyl acetal (14) and its 4'-deoxy analog 15 with 2-fluoro-, 2,2-difluoro- and 2,2,2-trifluoroethyl trifluoromethanesulfonates. The relationship between the antibacterial activity and the numbers of the fluorine atoms introduced in the final products is discussed.

Leucomycins↗
PubMed1984

[Pathophysiological assessment of continent ileostomy in patients with ulcerative colitis--with special reference to the internal pressure and capacity of ileostomy].

Eight patients subjected to surgery for ulcerative colitis were followed up 1-27 years. Of eight, 3 patients received Kock's continent ileostomy and 5 patients end ileostomy. The survey was performed mainly in terms of emptying frequency, the internal pressure and the capacity of the ileostomy. The patients with continent ileostomy empty their reservoirs one to four times a day, while the patients with end ileostomy change the ileostomy bags four to ten times a day. In patients with Kock's ileostomy, high pressure zone was observed at 3 to 6 cm proximal to the stoma corresponding to the site of the nipple valve. The pressure of the nipple valve showed higher than the internal pressure of the reservoir. When the internal pressure at the site of 10 cm proximal to the stoma was measured after end ileostomy, it increased proportionally to the amount of infused saline. Infusion of 50 ml of saline induced its evacuation from the stoma without causing any sensation of fullness to the patients. The patients with Kock's ileostomy announced sensation of fullness when 80% of the maximal capacity of the reservoir was filled with saline. This sensation of fullness made it easy for the patients to control emptying the reservoir. Therefore, we conclude that Kock's procedure should be more widely performed to ulcerative colitis when ileostomy is required.

Adolescent↗
PubMed1984

Removal of protein-bound substance in hepatic failure: polyetherurethane sheet embedded with powdered charcoal (UPC).

For the purpose of applying an artificial liver support system to a direct hemoperfusion (DHP), a new type of adsorbent, "polyetherurethane sheet embedded with powdered charcoal (UPC)" has been developed and clinically used. A polypropylene container was used to prepare a column containing 70 g of powdered charcoal by filling it with a 35 m x 15 cm roll of the 150 microns thick UPC. The powdered charcoal with an optimum pore size was selected for the purpose of adsorbing protein-bound substances and middle molecular substances. The result of a 3-hour DHP performed on a jaundiced dog showed the removal amounts of about 70% of bilirubin and 90% of bile acid. DHP was also performed on jaundiced patients. A 3-hour hemoperfusion using one UPC column obtained the maximum removal amounts of 23% of total bilirubin and 31% of bile acid. When 3 columns in all were used, one at a time, by replacing it with time, the removal amounts of 43% of total bilirubin and 55% of bile acid resulted. The hemoperfusion was safely completed with transient effects, if any, on the blood elements.

Adsorption↗