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Biomedical subjects

T Tsubokawa

Publications and source records attributed to T Tsubokawa.

At least 127 records · Page 7Linked to original sources
PubMed1989

[Neuroradiological image analysis and prognostic factors of malignant gliomas in the cerebral hemisphere of adults].

54% cases of malignant gliomas followed more than 2 years were studied about prognostic factors focusing on neuroradiologic image analysis in the two groups classified survival cases over 2 years and dead cases within 2 years after surgical treatment. 21% cases of malignant gliomas having tumor infiltration or edema to contralateral hemisphere on CT and MRI before treatment were dead within 2 years. 80% of recurrent malignant gliomas had abnormal shadow on CT due to tumor recurrence in primary tumor site or ventricular wall and/or contralateral hemisphere continuing with there. Remote metastasis discontinuing with primary site was demonstrated in only 20% of them. Over 90% of glioblastoma multiforme showing irregular tumor stain with arteriovenous fistula on angiogram were dead within 2 years, whereas in the cases without tumor stain the alive cases more than 2 years increased comparing with those having tumor stain.

Adult↗
PubMed1988

Preoperative determination of the level of spinal cord lesions from the killed end potential.

To determine preoperatively the level of lesions in acute cervical cord injury, the killed end potential of the spinal cord was recorded with a pair of electrodes placed in the spinal epidural space, one initially being placed rostrally to the lesions for obtaining recordings and the other placed caudally to the lesions for stimulation. The level associated with the largest killed end potential was clearly determined without much difficulty, with sequential recordings on stepwise withdrawal of the recording electrode, in four of five cases investigated. In two cases subjected to surgery, the recording electrode left in place at the level associated with the largest killed end potential was found to be located at, or a few millimeters below, the center of the lesions. This demonstrates the preoperative localizing value of the killed end potential for determining the level of lesions responsible for myelopathy.

Evoked Potentials↗
PubMed1988

Supranormal levels of serotonin and its metabolite after raphe cell transplantation in serotonin-denervated rat hippocampus.

Transplantation of fetal raphe cells (14 days of gestation) into the adult rat hippocampus, 2 weeks following serotonin (5-HT)-denervation with intracisternal injection of 5,7-dihydroxytryptamine, can restore 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) levels in the hippocampus to far beyond normal values. Transplantation into the unilateral hippocampus produces asymmetrical turning behavior after administration of the 5-HT releasor, p-chloroamphetamine (IP), comparable to the behavior reported for rats with 5-HT denervation of the unilateral hippocampus. The effect is blocked by prior depletion of 5-HT with p-chlorophenylalanine (IP). The asymmetry in 5-HT levels are correlated with the behavioral change. These data indicate that a large amount of 5-HT is released from nerve terminals of transplanted raphe cells, and suggest that the supranormal levels of 5-HT and 5-HIAA after raphe cell transplantation are neurochemical correlates of 5-HT hyper-innervation of the hippocampus which has been reported previously.

5,7-Dihydroxytryptamine↗
PubMed1988

Corticospinal direct response in humans: identification of the motor cortex during intracranial surgery under general anaesthesia.

The corticospinal direct (D) response to stimulation of the motor cortex exposed for intracranial surgery was recorded in 20 cases from wire electrodes inserted into the spinal epidural space. The D response was obtained from stimulation of restricted areas of the cerebral cortex, that is, the hand, trunk and thigh areas of the motor cortex. The D response was resistant to anaesthesia and unaffected by muscle relaxants. Thus, recordings of the D response are useful for identifying the location of the motor cortex during intracranial surgery under general anaesthesia.

Anesthesia, General↗
PubMed1988

[Metastatic brain tumor originating from the cardiac sarcoma].

A 39-year-old woman had suddenly onset of headache, aphasia and right hemiparesis. CT scan revealed a mass lesion in the left parieto-temporal lobe. The brain tumor was resected twice. But, heart tumor could not be resected because congestive heart failure progressed rapidly. At last, she succumbed to systemic metastasis at 4 months after the onset of symptoms. At autopsy, tumors were found to be localized in left atrium of the heart, left parietal lobe, bilateral occipital lobe of the brain, pancreas, liver and stomach. Histological examination was diagnosed as a malignant-fibrous-histiocytoma. Review of the literature reveals no other case with cerebral metastasis of malignant-fibrous-histiocytoma.

Adult↗
PubMed1988

[The effect on the tumor vessel permeability by hyperosmotic blood brain barrier disruption].

The limited effect of chemotherapy on malignant brain tumors has been related to tumor cell insensitivity to the drugs and to their ineffectual delivery to the tumor. The studies by Groothuis and Neuwelt et al have shown that the studies of tumor vessel permeability show considerable variability in different areas of tumors and between different tumor models. The present studies used the 9L gliosarcoma model in Fischer 344 rats to evaluate the increase of tumor vessel permeability by osmotic BBB opening on drug delivery to the tumor, brain adjacent to tumor (BAT), and brain distant to tumor using cis-diamminedichloroplatinum (CDDP) as a chemotherapeutic agent which was water soluble and rarely permeable to BBB. In addition the difference of delivery to normal brain and tumor tissue were studied on intravenous or intracarotid administration of cisplatin with or without intracarotid infusion of graded (20%, 25%) hyperosmolar mannitol. Evans blue, which binds to plasma albumin, was used to provide a visual marker of BBB opening. 20% or 25% hyperosmolar mannitol infusion to right internal carotid artery for BBB disruption was done at 0.12 ml/sec for 30 sec with controlled respiration after temporally clipping of right common carotid artery. Then cis-diamminedichloroplatinum (CDDP) was infused at 0.5 mg/ml/100 gr (body weight). In control studies isotonic saline instead of mannitol was infused to intracarotid artery at identical rate and volume. In 14 9L gliosarcoma bearing rats and 3 normal rats cis-diamminedichloroplatinum (CDDP) delivery to tumor and normal brain.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1987

Benign osteoblastoma of the temporal bone of an infant.

Benign osteoblastoma is a rare neoplasm of bone tissue most commonly involving the vertebral column and long bones. Occurrence in the calvarium is extremely rare, and no cases in infants have previously been described. We report a case of benign osteoblastoma occurring in the temporal squama of an infant. The clinical features of this type of tumor occurring in the calvarium are briefly discussed.

Age Factors↗
PubMed1987

Meningeal chondrosarcomatous tumor associated with meningocytic differentiation.

Most meningeal chondrosarcomatous tumors have been regarded as identical to similar tumors occurring elsewhere in the body. The neoplasm reported here, however, clearly demonstrated transitions between usual meningiomas and chondrosarcomatous tumors. The present case thus provides evidence in support of Cushing's and Eisenhardt's proposal that some meningeal chondrosarcomatous tumors are derived from meningeal cells and are histogenetically related to meningiomas.

Aged↗
PubMed1987

Solitary hemangioblastoma within the third ventricle.

A case of solitary hemangioblastoma within the third ventricle is presented. This case was not associated with von Hippel-Lindau disease. Only two other cases of hemangioblastoma arising in the third ventricle have been previously reported.

Adult↗
PubMed1987

Angioma of the cerebellopontine cistern simulating acoustic neurinomas.

We report a cryptic angioma associated with a cisternal hematoma confined to the cerebellopontine cistern occurring in a 29-year-old woman. The angioma was related to the acoustic nerve. The cisternal hematoma appeared to have increased in size gradually with repeated hemorrhages from the angioma. The location of the lesion, in conjunction with the gradual size increase of the cisternal hematoma, resulted in the lesion simulating acoustic neurinomas radiologically as well as neurologically.

Adult↗
PubMed1987

Somatosensory evoked potentials from the thalamic sensory relay nucleus (VPL) in humans: correlations with short latency somatosensory evoked potentials recorded at the scalp.

Somatosensory evoked potentials (SEPs) were recorded in humans from an electrode array which was implanted so that at least two electrodes were placed within the nucleus ventralis posterolateralis (VPL) of the thalamus and/or the medial lemniscus (ML) of the midbrain for therapeutic purposes. Several brief positive deflections (e.g., P11, P13, P14, P15, P16) followed by a slow negative component were recorded from the VPL. The sources of these components were differentiated on the basis of their latency, spatial gradient, and correlation with the sensory experience induced by the stimulation of each recording site. The results indicated that SEPs recorded from the VPL included activity volume-conducted from below the ML (P11), activity in ML fibers running through and terminating within the VPL (P13 and P14), activity in thalamocortical radiations originating in and running through the VPL (P15, P16 and following positive components) and postsynaptic local activity (the negative component). The sources of the scalp-recorded SEPs were also analyzed on the basis of the timing and spatial gradients of these components. The results suggested that the scalp P11 was a potential volume-conducted from below the ML, the scalp P13 and P14 were potentials reflecting the activity of ML fibers, the small notches on the ascending slope on N16 may potentially reflect the activity of thalamocortical radiations, and N16 may reflect the sum of local postsynaptic activity occurring in broad areas of the brain-stem and thalamus.

Electroencephalography↗
PubMed1986

Preferential accumulation of 11C in human brain tumors after intravenous injection of 11C-1-pyruvate.

Regional cerebral turnover of 11C following intravenous injection of 11C-1-pyruvate was investigated in 12 patients with brain tumors. The positron emission tomography (PET) image taken at 10-15 min after the injection always demonstrated a high concentration of 11C in tumor, and thus visualized precise tumor contours. This phenomenon was not influenced qualitatively by the variation of blood flow in the tumor. Brain edema associated with the tumor was not visualized. We conclude that the localization of brain tumors would be well determined by the PET scan, using 11C-1-pyruvate.

Adult↗
PubMed1986

Destructive hydrocephalus: a proposed new category.

A case is reported with hydrocephalus subsequent to neonatal intraventricular and intracerebral hemorrhage. Hydrocephalus was diagnosed as obstructive, secondary to subarachnoid hemorrhage. However, the lateral ventricle in the hemisphere in which the intracerebral hemorrhage occurred dilated much more than that in the contralateral hemisphere. Hydrocephalus occurring in regions of the brain that have suffered destructive changes from a cause other than that of the hydrocephalus, as in this reported case, is proposed as a new category, ("destruction hydrocephalus"). It is to be distinguished from hydrocephalus with dilated ventricles due simply to increased intraventricular pressure. In "destructive hydrocephalus" dilatation of the ventricles occurs irregularly and rapidly, leading to secondary cerebral destruction. Therefore, treatment to prevent the progressive cerebral damage is required immediately.

Cerebral Cortex↗