Search PubMed⌕ Search

Biomedical subjects

T Tojo

Publications and source records attributed to T Tojo.

At least 109 records · Page 6Linked to original sources
PubMed1989

[Studies on factors causing tooth resorption. 1. Role of prostaglandins as a chemical mediator on resorption of deciduous teeth in rabbits].

The aim of this study was to investigate the effects in the administration of indomethacin which is a specific inhibitor of prostaglandins (PGs) in order to understand the role of PGs in physiologic root resorption. For this study, 24 young rabbits aged 7 days which had been in utero for 31-32 days were used. The experimental group (N = 12) was injected with 5.0 mg/kg indomethacin every 12 h, and the control group (N = 12) was injected with normal saline solution every 12 h. 4 animals of each group were sacrificed at the 9th, 11th and 13th day, respectively. Their maxillary deciduous incisors embedded in paraffin were sectioned serially 7 mus in thickness. From each sample was counted the number of odontoclasts appearing on the root surface and measured the volume of the root in the maxillary deciduous incisor. The results were as follows: 1. The appearance of odontoclasts increased in a day-related manner from 9 days to 13 days on the resorption of maxillary deciduous teeth in the control and experimental rabbits. 2. The number of odontoclasts was significantly decreased by the administration of indomethacin (9 days P less than 0.05, 11 and 13 days P less than 0.01). 3. The amount of the root resorption was significantly inhibited by the administration of indomethacin at 9 days which was the initial stage of root resorption in the maxillary deciduous incisors, and then the effect of inhibition rapidly disappeared. These results strongly suggest that PGs can possibly act as a chemical mediator of odontoclastic root resorption occurred during tooth exchange.

Animals↗
PubMed1988

Pyloric stenosis in a patient with progressive systemic sclerosis.

A 64-year-old Japanese woman with progressive systemic sclerosis (PSS) who developed severe pyloric stenosis is described. The conservative treatments brought only the temporary symptomatic relief, and pyloroplasty became necessary. No ulcerative lesions or tumors were found in the resected stomach or duodenum specimens implicated for stenosis. The histological examinations revealed edema and replacement fibrosis in the pyloric ring. The possible mechanisms of pyloric stenosis are discussed.

Female↗
PubMed1987

Mixed connective tissue disease with pulmonary hypertension: a clinical and pathological study.

Clinical and autopsy findings of 2 cases with mixed connective tissue disease (MCTD) associated with severe pulmonary hypertension are reported. Both cases showed marked intimal and medial thickening in small and medium sized pulmonary arteries. In one of the cases plexiform lesions, endarteritis obliterans, and fibrous intimal thickening of the pulmonary veins were recognized. In some cases with MCTD, pulmonary hypertension develops due to pulmonary vascular lesions which are similar to those of primary pulmonary hypertension.

Adult↗
PubMed1986

Inhibition of topoisomerase I by antibodies in sera from scleroderma patients.

Purified type I topoisomerase from calf thymus as well as nuclear and cytoplasmic extracts from EGF-stimulated human and mouse fibroblasts in cell culture efficiently convert supercoiled plasmid DNA to the relaxed form. The purified IgG fraction from the sera of Japanese patients with the rheumatic disease scleroderma were shown to inhibit this relaxation activity. Thus, these patients likely produce autoantibodies to topoisomerase I. In addition, the human, bovine and murine enzymes share antigenic determinants recognized by the antisera.

Animals↗
PubMed1986

Anti-Ro/SSA and -La/SSB antibodies in patients with connective tissue diseases.

The frequency of anti-Ro/SSA and anti-La/SSB antibodies in patients from Japan with Sjögren's syndrome, systemic lupus erythematosus (SLE), progressive systemic sclerosis (PSS), polymyositis-dermatomyositis (PM-DM), rheumatoid arthritis (RA) and blood donors is reported. Anti-La/SSB ab was especially detected in patients with severe glandular and extraglandular manifestation and could be found in sera years prior to the confirmation of Sjögren's syndrome. The purified Ro/SSA antigen consisted of 60 k peptide and 16 k RNA while the La/SSB antigen consisted of 41 k and 29 k peptides. Some molecular association seems to exist between the peptides and corresponding IgG anti-Ro/SSA and anti-La/SSB antibodies.

Antibodies, Antinuclear↗
PubMed1981

[Prophylaxis and treatment of streptococcus infections (author's transl)].

Authors review and bring up to date problems related to prophylaxis and treatment of streptococcus infections in children. In those caused by the Group A streptococcus, the problem is rather one of medical education and practical application of techniques, and medicines. Active vaccination is still a remote possibility. In the case of streptococcus B and its perinatological incidence, there is still no standard therapeutic prophylaxis covering both the mother and child. With reference to streptococcus D plans proposed are somewhat discordant since it is difficult to carry out studies with sufficiently large groups but there are also proposals which can be carried out perfectly well and are reasonably safe. As far as the infectious, and to a great extent contagious, processes are concerned, measures of individual and collective hygiene are particularly important.

Anti-Bacterial Agents↗