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T Toivonen

Publications and source records attributed to T Toivonen.

25 records · Page 2Linked to original sources
PubMed1987

[Medical slang].

Explore the source record for details and available documents.

Terminology as Topic↗
PubMed1981

Antihypertensive action of drug combination: Timolol, hydralazine, hydrochlorothiazide and triamterene.

A fixed combination tablet containing 5 mg of timolol, 25 mg of hydralazine, 25 mg of hydrochlorothiazide and 37.5 mg of triamterene was prepared and its antihypertensive effect compared with placebo in a randomized double-blind cross-over study lasting 16-20 weeks. 37 patients entered the study and 32 of them completed it. The trial drug caused a highly significant drop in blood pressure in both the supine and standing positions (from 172/112 to 142/91 mm Hg supine and from 168/17 to 136/100 mm Hg standing). There was also a highly significant fall in heart rate. Three patients were nonresponders with maximal dose used (4 tablets daily) and two patients had to withdraw from the trial because of complications. In general the side effects recorded were mild and equally common both on placebo and the trial drug. The serum potassium level was well maintained. The serum urate concentration was increased, but no signs of gout were observed. The conclusion was that this fixed combination of timolol, hydralazine, hydrochlorothiazide and triamterene is effective and well tolerated in the treatment of mild to moderate hypertension.

Adult↗
PubMedDate not supplied

Large-volume cytocentrifuge for processing alcohol-fixed cytologic specimens. Application in urinary cytology.

The use of a large-volume cytocentrifuge for the routine processing of urine specimens was investigated. Most specimens arrived in the laboratory mixed with 50% ethanol. Polyethylene glycol was added to the fixative supplied to the clinicians or to the cell suspension received in the laboratory. The slides used in the cytocentrifuge were coated with gelatin or poly-L-lysine to minimize cell loss. The resulting monolayers of cells, with occasional true tissue fragments, were stained by the Papanicolaou method. When indicated, immunocytochemical and histochemical stains were used. The technique gave good morphologic details, good cell yield and consistent staining quality. This method has also been applied to other cytologic specimens, such as serous fluids and fine needle aspirates, with good results. The method saves the time of cytotechnologists, and slides prepared by this technique are suitable for automatic staining.

Cell Separation↗
PubMedDate not supplied

Preparation of methacrylate-embedded cytologic smears from prefixed cells.

A new method of preparing smears of alcohol-fixed cytologic material by using methacrylate embedding medium to make the cells adhere on plain glass slides is presented. After centrifugation, the cytologic material was mixed with Lowicryl K4M embedding medium and smeared on slides. The polymerization process was achieved by exposing the slides to ultraviolet light. The morphology in such smears was similar to that of specimens prepared by the filter technique. The methacrylate method does not have the most common disadvantages of the filter technique--the development of air bubbles over time and the visually disturbing presence of the filter.

Acrylates↗