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Biomedical subjects

T Togo

Publications and source records attributed to T Togo.

77 records · Page 5Linked to original sources
PubMed1977

Urinary hydroxyproline, creatinine and urea excretion during the growth of five siblings.

Urinary excretions of hydroxyproline, creatine and urea in 24 h specimens from 5 siblings have been determined monthly from 1971 to 1976 together with the measurements of body height and body weight. Changes with age in the urinary levels of these substances are in good agreement with those from cross-sectional studies in various age groups of children. Wide fluctuations of excretion levels occurred. The creatinine coefficients did not remain constant even over short periods. Menarche was observed shortly after the peak of hydroxyproline excretion at puberty. The hydroxyproline excretion pattern is similar to that of hydroxyproline index proposed by Whitehead, and it is quite different from that of hydroxyproline ratio.

Adolescent↗
PubMedDate not supplied

Time-series analysis of stature and body weight in five siblings.

Since 1971, stature and body weight in five siblings have been measured monthly. Time-series analysis of stature, body weight and their increments per month was made by the Program of Census Method IIX11 resulting in three components: a trend-and-cycle factor, a seasonal factor and an irregular factor. Significant seasonal variation was found in both stature and body weight. In two young subjects, trend curves of stature are very close to each other while those of body weight are different. Trend factor in increment indicates that growth rate of stature or body weight fluctuates, instead of being smooth, suggesting that from birth to maturity acceleration and deceleration occur alternately, like repeated retardations and subsequent catch-ups. A high peak of body weight increment precedes menarche by 1 1/2 years in two girls. In one case, no adolescent spurt in stature was observed while a high peak appeared in body weight in that period. Irregularity in stature is about one-tenth that of body weight when the two are compared in terms of the ratio of SD of irregular factor/mean of trend factor. The raw data are given in an appendix.

Adolescent↗
PubMedDate not supplied

Dementia with Lewy bodies showing advanced Lewy pathology but minimal Alzheimer pathology--Lewy pathology causes neuronal loss inducing progressive dementia.

The present study concerns an autopsied case of dementia with Lewy bodies (DLB) showing advanced Lewy pathology but minimal Alzheimer pathology. The patient was a 50-year-old Japanese male without inheritance. His initial symptoms at the age of 43 suggested the diagnosis ofjuvenile idiopathic Parkinson's disease (PD), but were followed by memory disturbance 1 year later. He showed parkinsonism, dementia, personality change, fluctuating cognition and visual hallucinations 3 years later. Neuroradiological examination revealed moderate brain atrophy, predominantly in the frontal and temporal lobes. Neuropathological examination demonstrated a widespread occurrence of Lewy bodies (LB) with LB-related neurites not only in the brainstem but also in the cerebrum. The present case showed Lewy pathology which corresponded to stage IV by our staging and was parallel to neuronal loss. There was marked neuronal loss with many LB-related neurites in the CA2 of the hippocampus. Neurofibrillary tangles (NFT) were almost restricted to the entorhinal cortex, while senile plaques were absent. Consequently, the present case was pathologically diagnosed as having DLB of the neocortical type, pure form. In the present study, we suggest that Lewy pathology in the cerebral cortex could be responsible for progressive dementia.

Alzheimer Disease↗
PubMedDate not supplied

Surgical treatment for isolated hypoplasia of the right ventricle.

Four patients with isolated hypoplasia of the right ventricle who underwent intracardiac repair are described. An atrial septal defect (ASD) was successfully closed in 3 patients with mild hypoplasia of the right ventricle. The remaining patients underwent ASD closure and right atrium-to-pulmonary artery connection with a conduit with a bovine pericardial valve because of severe hypoplasia of the right ventricle and tricuspid valve. Postoperative angiocardiogram in the last patient demonstrated two-channel pathways from the right atrium to the pulmonary artery via both the right ventricle and external conduit. At long-term follow-up studies, 3 patients had developed arrhythmias and/or sinus node dysfunction, and one had died, probably because of arrhythmia, 13 years postoperatively. The right ventricular ejection fractions were below normal levels at 11 and 12 years postoperatively in 2 patients who underwent closure of ASD. It was concluded that the mild form of hypoplasia of the right ventricle should be surgically corrected by ASD closure, while right atrium-to-pulmonary artery connection or Fontan's operation should be chosen for cases of severe hypoplasia. Arrhythmias and hypofunction of the right ventricle are long-term problems after intracardiac repair of this anomaly.

Adolescent↗