The effect of albendazole and mebendazole was studied in 25 patients with severe, multiple, inoperable echinococcosis. Eleven patients were treated with albendazole 10 mg/kg/day for four courses of 30 days with 15-day drug-free intervals and 14 with mebendazole 50-70 mg/kg/day continuously for between 6 and 24 months. The determination of cyst response was based on the changes in cyst appearance as seen by radiography, ultrasound and computed tomography. Albendazole and mebendazole were found to have favourable effects in patients with severe, inoperable hydatid disease, although the degree of response varied. Treatment with albendazole was successful in seven cases, partially successful in two, and failure was noted in the other two patients. In patients treated with mebendazole, success was established in three, partial success in five and failure in six cases. The differences in response were mainly associated with cyst condition and the drug used. In some cases long-term therapy and retreatment should be recommended.

Adult↗

PubMedDate not supplied

Tissue microarray analysis of cyclin D1 gene amplification and gain in colorectal carcinomas.

Colorectal cancer is one of the most common neoplastic diseases and one of the leading causes of cancer-related deaths. Elevated beta-catenin levels in colorectal cancer result in the binding of beta-catenin to LEF-1 and increased transcriptional activation of the CCND1 gene. Overexpression of cyclin D1 is observed in one third of colorectal tumors. CCND1 amplification is the main cause of protein overexpression in numerous human carcinomas. In colorectal cancer, however, no CCND1 amplification has been reported so far. The aim of this study was to determine the frequency of CCND1 amplifications and gains in a large number of colorectal carcinomas, arranged in a tissue microarray, in order to assess their role in colorectal cancer development. The copy number changes, detected by fluorescence in situ hybridization, were predominantly gains (7.6%) and only rarely amplifications (2.5%). In colorectal cancer, the CCND1 copy number increase was neither associated with the tumor phenotype (stage and grade) nor with the tumor localization (colon, rectum or sigmoid colon). In conclusion, even in a small number of colorectal tumors, CCND1 gene amplification is a possible mechanism for the increase in cyclin D1 oncoprotein.

Colonic Neoplasms↗

PubMedDate not supplied

[Incidence and causes for fracture of removable plaque prostheses].

The great number of subjects in the former Mihajlovgrad district, asking for repair of removable dentures, provided grounds the author to study clinically that problem. A total of 324 subjects, aged from 16 to 90, with 320 prostheses were inquired according to various indices. Interstings facts and regularities were established necessitating an original prophylactic activity for reduction of the number of breakings and prolongation the functional fitness of the plaque partial prosthesis, in mass use in the practice. The upper prostheses are broken three times more often than the lower ones. The partial prostheses are broken 1.7 times more than the total. Almost half of all broken prostheses (47.38%) are upper partial. The most frequent defect is a broken prosthesis with complete separation of the fragments (56.20%). The cracked prostheses are 21%. Two thirds of all prostheses received (65%) are repaired more than once and 1/3 of all prostheses are repaired 3 and more than 3 times. Treatment with practically healed prostheitic field has been performed in only 20 per cent of the subjects. The author proposes a simultaneous laboratory lining in cases of broken old prostheses and the existence of great changes in the prosthetic field. Close attention is recommended in the clinical design and laboratory making of the upper partial prosthesis.

Adolescent↗

PubMedDate not supplied

[Precious stomatological alloy with reduced gold content. I. Laboratory and clinical studies].

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Biocompatible Materials↗