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Biomedical subjects

T Tobe

Publications and source records attributed to T Tobe.

At least 523 records · Page 29Linked to original sources
PubMed1976

Serum antibodies to herpesvirus early antigens in patients with cervical carcinoma determined by anticomplement immunofluorescence technique.

Sera from patients with carcinoma of the uterine cervix were used with the anticomplement immunofluorescence (ACIF) technique to develop a simple procedure for detection of antibodies to herpes simplex virus type 2 (HSV-2) early antigens. Test cells used in the ACIF assay were HEp-2 cells infected with HSV-2 sequentially treated with inhibitors of protein and of DNA SYNTHESIS. The cells were first treated for 7 h with cycloheximide (100 mug/ml) and then for 3 h with hydroxyurea (150 mug/ml). In this assay serum titers giving more than 21.5% ACIF-positive cells correlated to invasive carcinoma of the cervix. Using these criteria 18 out of 43 patients with invasive carcinoma, none of 8 patients with carcinoma in situ, and only 1 of 43 controls, were diagnosed as positive. Thus an elevated titer of antibodies against HSV-2 antigens correlated to cervical carcinoma.

Antibodies, Viral↗
PubMed1976

Distribution of gastrin in canine, cat, and human digestive organs.

In dogs, cats, and humans, gastrin-containing cells were found only in the antrum and in the duodenum by specific direct immunofluorescence. Distribution within the human duodenum, however, differed from that in cats and dogs. No gastrin-containing cells were seen in other sites of the body.

Animals↗
PubMed1975

Cellular sites of immunoglobulins . VI. Localization of immunoglobulins in the human thymus.

IgG-, IgM and IgA-containing cells in the human thymus and mesenteric lymph nodes were studied by direct, double-antibody immunofluorescence techniques. Ig-containing cells were identified in the thymic medulla but not in cortical or paracortical zones. About 93 percent of the medullary Ig-containing cells were IgG-containing (vs. 5 percent IgM containing and 2 percent IgA - containing). By contrast, lymph nodes contained about 53 percent IgG, 31 percent IgA and 16 percent IgM type immunocytes. In addition, Ig-containing cells were about one-tenth as numerous in thymus as in lymph nodes.

Adolescent↗