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Biomedical subjects

T Tateishi

Publications and source records attributed to T Tateishi.

At least 163 records · Page 9Linked to original sources
PubMed1984

Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.

[3H]-tryptamine is taken up by rabbit platelets through an active and saturable process which is temperature sensitive, sodium-dependent and inhibited by imipramine and non-tricyclic 5-hydroxytryptamine (5-HT) uptake blockers. There is an excellent correlation between the Ki for the inhibition of [3H]-tryptamine and [3H]-5-HT uptake in rabbit platelets for a series of 5-HT uptake blockers. These results indicate that [3H]-tryptamine is actively transported through the membrane of blood platelets by the same carrier that transports 5-HT.

Animals↗
PubMed1984

Mechanical properties of the electrically stimulated callus. An experiment with constant direct current in rabbit fibulae.

The investigation of the effect of direct current on the mechanical properties of experimental fractures was conducted by applying 7-10 microA of constant current to the osseous defect of the rabbits' fibulae. The fibulae were tested mechanically with the combined methods of nondestructive technique and breaking-strength measurement. The result was analyzed in relation to the volume of the newly formed callus, which was estimated by roentgenographic appearance and calculation. There is no accurate proof that an electrically stimulated callus is superior in mechanical strength. A more massive callus in a relatively earlier stage suggests that the stimulated callus may have some advantages over the nonstimulated callus.

Animals↗
PubMed1981

Serotonin metabolism of animal model of depression.

All results presented here would indicate that serotonin plays an important role in animal behavior such as locomotor depression and that, taking into consideration the effects of antidepressants on 5-HT receptor activity as well as recent biochemical findings of human depression, some forms of human depression could be induced by a cerebral serotonergic receptor hyperactivity contrary to a conventional theory of serotonin deficiency in the synaptic cleft in the brain.

Animals↗
PubMed1980

A new socket design for the dysplastic acetabulum in total hip replacement.

A special socket was designed by holography for total hip replacement for the treatment of the dysplastic acetabulum and correction of the deformation pattern. Excellent clinical results of 12 cases demonstrate that the special socket design provides good stability as well as favorable redistribution of mechanical forces about the hip joint.

Acetabulum↗
PubMed1978

Animal model of depression. III. Mechanism of action of tetrabenazine.

A study was undertaken to gain an understanding of the biochemical mechanism whereby tetrabenazine (TBZ) produces a sedative effect on the locomotor activity of rats. Rats injected with L-5-hydroxytryptophan (L-5-HTP, 30 mg/kg), the immediate precursor of 5-hydroxytryptamine (5-HT), showed the characteristic bison appearance, pitosis, and catalepsy normally observed after injecting TBZ (30 mg/kg). The treatment of rats with low doses of L-5-HTP (9 mg/kg) plus TBZ (2 mg/kg) significantly decreased locomotor activity, whereas low doses of either one of these drugs given alone had no significant effect on locomotor activity. The level of 5-hydroxyindoleacetic acid (5-HIAA) was elevated in the brain of rats sacrificed 3 hr after treatment with low doses of either L-5-HTP or TBZ alone. Treatment of rats with p-chlorophenylalanine to inhibit the synthesis of 5-HT had an inhibitory effect on the duration of sedation following an injection of TBZ (30 mg/kg). The results of the biochemical and pharmacological studies as reflected by changes in locomotor activity were interpreted to indicate that the sedative action of TBZ was due to an excess of functional 5-HT.

5-Hydroxytryptophan↗
PubMed1977

Circadian susceptibility rhythm to neuroleptics: tetrabenazine.

In order to clarify the influences of situational factors on the effects of psychotropic drugs, the sedative effects of tetrabenazine after injection at various times of the day were studied. When 50 mg/kg body weight of tetrabenazine was injected into rats at eight different times of the day (07:30-19:30 dark, 19:30-07:30 light), a circadian rhythm of sedative effect was observed with a peak sedative time of 1490 min at 10:30 and a nadir of 736 min at 07:30. With 10 mg/kg body weight of tetrabenazine a similar circadian rhythm of sedative effect was observed. This rhythm did not appear to be due to differences of metabolism of tetrabenazine in the tissues, but rather to be closely related to daily fluctuation of serotonin synthesis and release in the brain.

Animals↗
PubMed1976

Biochemical basis of an animal model of depressive illness--a preliminary report--.

Biochemical analyses of brain samples of an Animal Model of Depression indicate the state of motionlessness observed in response to a conditioned stimulus was due to an excess in functional activity of serotonin. An excess functional activity of serotonin may be directly responsible for human depressive illness. This conflicting conclusion to the currently popular theories of serotonin deficiency was discussed with reference to the animal and clinical data in the literature which are consistent with the conclusion.

Adjustment Disorders↗