[Studies on the serum levels of a carbohydrate antigen 19-9 (CA 19-9) in patients with ovarian cancer].
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Biomedical subjects
Publications and source records attributed to T Tasaki.
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To determine the clinical significance of intraperitoneal cancer cells, comparative cytologic studies on ovarian cancer cells in peritoneal washings and ascites were performed. The materials obtained from 6 patients with ovarian cancer were examined by light microscopy (LM), scanning electron microscopy (SEM) and transmission electron microscopy (TEM), and the results achieved were as follows: Ovarian cancer cells were recognized in both peritoneal washings and peritoneal effusion. It was easier to get a diagnosis from the cytologic features of the peritoneal washings than those of the effusion, because of the fewer contaminants such as fibrin, red blood cells and other degenerated tissues. Despite the presence of clustered cells in the washings, the nuclei and cytoplasmas were clearly seen. On SEM observation of the clustered cells from the effusion, red blood cells and fibrin were seen to adhere to the surface of cancer cells. Ultrastructural observation of cancer cells by TEM confirmed the fact that the activity of the cells was maintained even in ascites.
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A case of multicystic kidney diagnosed by computed tomography (CT) and confirmed at surgery is presented. On CT, the lesion appeared as an abnormal mass composed of numerous walled, low density areas of varying sizes consistent with the surgical finding of congenital multicystic kidney.
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The mechanism of the irregularity of R-R intervals and especially the genesis of the long R-R intervals in atrial fibrillation were clarified. From the point of view of the present study, the sequence of successive R-R intervals can be regarded as a stochastic process, and consequently mathematical analyses can be applied, and the following conclusion could be obtained: the stability of the data, mathematically called stationarity, is present in the sequence of R-R intervals, and these intervals are independently and identically distributed. The probability density function is an Erlangian distribution with phase k of 20 to 26. Namely, as soon as, on the average, 20 to 26 atrial excitatory stimuli have arrived at the AV node, a threshold value of the AV node is reached and ventricular activation is induced. However, if we examine the mathematical structure of the sequence of successive R-R intervals in more detail, the following results can be evidently obtained: during atrial fibrillation with rapid ventricular response, the sequence of R-R intervals is completely independent, but with intermediate or slow ventricular response the adjacent R-R intervals correclate with each other and these adjacent intervals have at least the first order Markov property, which seems to be caused by the concealed conduction. Because of this Markow property due to the prolongation of the refractory period of the AV node, slow ventricular response results.
We report a family in which five members in three generations have been afflicted with Duane syndrome. Four of the five members also have congenital hypoplasia of the thenar eminence. One also was afflicted with Hirschsprung disease and another was born deaf. A sixth member, who does not have Duane syndrome, is afflicted with a more extensive malformation of the upper extremities and unilateral deafness. We present a discussion of Duane syndrome and its association with other congenital anomalies. Although some members of this family presented in this report show features that are similar to the Holt-Oram syndrome, Wildervanck's syndrome, and others reported in the literature, there are several unique features about this family that we thought were worth reporting.
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