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Biomedical subjects

T Tango

Publications and source records attributed to T Tango.

At least 55 records · Page 3Linked to original sources

[Studies on the operative factors affecting the reduction of chronic subdural hematoma, with special reference to the residual air in the hematoma cavity].

The authors previously reported the effect of preoperative factors affecting the reduction of chronic subdural hematoma. In this report, we evaluated some operative factors, including operative methods, duration of drainage, and residual air volume, with newly developed CT volumetry technique. As described before, the hematoma volume reduces exponentially. An exponential curve was fitted to the reduction curve using the least square method, and its half reduction days (HRD) was calculated. This HRD represents a mathematical indicator of the reduction rate of CSDH. Using this technique, the relationship between this HRD and operative method, the duration of drainage and the volume of the postoperative residual air were examined in 61 patients. Operative method (burr hole or small craniotomy) has no correlation with HRD. The duration of drainage also has no correlation. However, the volume of the residual air was highly correlated with the reduction rate of hematoma (r = 0.430; p less than 0.01). These results suggest that the residual air in the hematoma cavity may delay the reduction rate of the hematoma. Based on these results, the authors pay attention to the following points; 1) Less invasive burr hole method should be selected. 2) Patient's head position should be controlled to make the burr hole at the highest level in the operative field. 3) Hematoma cavity should be filled with saline as much as possible. 4) The inner membrane should never be injured, as it may cause tension pneumocephalus. Moreover, the drainage of cerebrospinal fluid may reduce the counter pressure and it leads to the delay of the hematoma reduction.

Adult↗

Clinical features and course of type A and type B vitiligo.

Four hundred and eighty one cases of vitiligo (acquired idiopathic depigmentation) were studied clinically. They were divided into two types, type B, in which depigmented patches are confined to a definite dermatome in the same manner as herpes zoster, and type A, which included all cases of vitiligo not classified as type B. The ratio of type A:type B was approximately 3:I. Onset of type A vitiligo could occur at any age, whereas type B generally affected the young. The activity of type B vitiligo usually ceased after one year, following rapid spread over the particular dermatomal area. However, in type A vitiligo new depigmented patches continued to appear throughout the patients' lives. Association with halo naevus and Köbner's phenomenon were observed exclusively in type A. Association with diseases with a proven or suggested allergic or immunological aetiology was more often found in type A. These findings support our hypothesis that type A and type B vitiligo have a different pathogenesis and that autoimmune mechanisms play a role only in type A.

Age Factors↗

[Studies of the factors affecting the reduction of chronic subdural hematoma: effect of preoperative factors with special reference to cerebral atrophy].

The authors examined the preoperative factors affecting the reduction of chronic subdural hematoma (CSDH). A new method was developed to calculate the reduction rate of CSDH using CT volumetry technique. Postoperative serial CT films were examined and each hematoma volume was calculated by microcomputer. A postoperative exponential decrease of hematoma volume was observed, and the log-transformation of the hematoma volume turned the curve to a linear decrease. The least square method was used to fit an exponential curve, and the half reduction date (HRD) was calculated from the fitting curve. This HRD represents a mathematical indicator of the reduction rate of CSDH. Using this technique, the relationships between this HRD and the following parameters were examined in 61 patients. The preoperative factors examined are as follows; 1) patient's age, 2) preoperative hematoma volume, 3) CT number of the hematoma, 4) time interval between the head injury and the onset of symptom, and 5) the degree of cerebral atrophy. The degree of cerebral atrophy was calculated by means of a simple approximate formula as described by one of the authors (K.N.). Patient's age and the hematoma volume were correlated with HRD, and the correlation coefficients were 0.346 (p less than 0.01) and 0.298 (p less than 0.05) respectively. On the other hand, preoperative CT findings and the duration from the trauma had no correlation with HRD. Cerebral atrophy has hitherto been thought to affect the reduction of hematoma. However, our quantitative study revealed no correlation between cerebral atrophy and the reduction of hematoma rate. This unexpected result may be attributed to the difference between cerebral atrophy and cerebral elasticity.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

Age, period and cohort analysis of trends in mortality from major diseases in Japan, 1955 to 1979: peculiarity of the cohort born in the early Showa Era.

Japanese researchers have reported that recent mortality rates from diabetes mellitus, ischemic heart disease, peptic ulcer, cirrhosis of the liver and suicide for middle-aged Japanese men have increased by comparison with those for other age groups. There has been some controversy over the etiology of this unusual trend, and in particular whether it is due primarily to recent undesirable socio-economic factors (period effects) or to factors specific to these cohorts born in the early Showa Era, around 1925 to 1940 (cohort effects). A possible source of this controversy lies in the methods which have been used to describe the trends; these are mostly descriptive and graphical. To elucidate which factors are responsible for these trends, we analysed the mortality data quantitatively applying an age-period-cohort model modified so that period effects remain constant within certain age groups but may vary from one age group to the next. Although the identifiability problem still occurs in the modified model, estimable curvature components of time effects may be used to examine these unusual trends. In fact, the peculiarity of the cohort born in the early Showa Era was clearly detected by the curvature components of cohort effects for these major diseases. These findings are consistent with the 'cohort hypothesis' for the recent peculiar trend in Japanese male mortality.

Adult↗

A quantitative study of physiological cerebral atrophy with aging. A statistical analysis of the normal range.

A new method of discriminating pathological cerebral atrophy from physiological atrophy during aging is reported. The authors advocate a pixel counting method using a minicomputer for the quantitative measurement of cerebral atrophy. Five hundred cases were studied with this quantitative method and the normal range of the physiological atrophy was determined statistically. In order to estimate the degree of cerebral atrophy easily, the conventional linear measurement methods were compared with the pixel counting method using multivariant analysis, and a simple formula for the calculation of the degree of cerebral atrophy is proposed. Using this formula and the normal range, pathological cerebral atrophy is easily detectable.

Adolescent↗

A comparative study of alteration in lymphocyte subsets among varicella, hand-foot-and-mouth disease, scarlet fever, measles, and Kawasaki disease.

Changes in the lymphocyte subsets of 13 patients with varicella, 5 with hand-foot-and-mouth disease, 4 with scarlet fever, 10 with measles and 20 with Kawasaki disease were examined by immunofluorescent flow cytometric analysis using monoclonal antibodies against lymphocyte cell surface antigens. The results were compared with those of age-matched normal controls. A significant increase in the percentage of Leu-2a positive (Leu-2a+) cells was shown during the early convalescence of varicella, scarlet fever and measles. A significant decrease in the percentage of Leu-3a+ cells during the acute phase was common to all the diseases examined, and a significant decrease of Leu-4+ cells was observed except in measles. As a result, a significant decrease in the Leu-3a+/Leu-2a+ ratio was common to all the diseases examined during the acute and/or early convalescent phases. Leu-M3+ cells increased significantly in varicella, scarlet fever, and Kawasaki disease. HLA-DR+ cells increased significantly in varicella and Kawasaki disease. No significant changes in the proportions of Leu-7+, Leu-10+, and 2H7+ cells were found throughout the course of all the diseases examined.

Adolescent↗

Lymphocyte subsets identified by monoclonal antibodies in healthy children.

The distributions of lymphocyte subsets and monocytes in the peripheral blood mononuclear leukocytes of 72 normal children from 2 months to 13 5/12 yr were examined using quantitative immunofluorescence analysis with monoclonal antibodies. Distinct decreases with age were found in the total leukocyte counts, the percentages and the absolute numbers of peripheral blood mononuclear leukocytes. The percentages of Leu-2a+ cells, Leu-7+ cells, and Leu-M3+ cells significantly increased with age, whereas the percentages of Leu-3a+ cells, Leu-4+ cells, and 2H7+ cells significantly decreased with age. As a result, ratios of Leu-3a+/Leu-2a+ decreased with age. No prominent differences with age were found in the proportions of Leu-10+ cells and HLA-DR+ cells.

Adolescent↗

[The normal range of cerebral atrophy during aging: statistical analysis of 500 normal subjects].

We previously reported the newly developed quantitative measurement of the cerebral atrophy (pixel count method), and advocated the value CCR (CSF-cranial ratio) as the index of the volumetric measurement of the cerebral atrophy. As the pixel count method is somewhat troublesome, we tried to compare the various linear measurement methods with pixel count method by means of multivariant analysis, and reported a single formula to calculate CCR from the linear measurement methods. Now we studied 500 normal subjects using the pixel count method and examined the normal range of the cerebral atrophy during aging by means of the maximum likelihood method. The normal range was estimated as follows; 0.32 less than y less than 5.78 (t less than 48), 0.068 t--2.944 less than y less than 0.368 t--11.884 (t greater than 48). Using these formula and this newly reported normal range, we can easily predict whether the cerebral atrophy is pathological or not.

Aging↗

[A quantitative study of brain atrophy on computed tomography--multivariate analysis for comparison between the linear measurement method and the pixel count method].

We previously reported the newly developed quantitative measurement of the cerebral atrophy. The data indicated that the volume of the cerebrospinal fluid not always gradually increases during the life course but remains relatively constant until age 50 and thereafter increases with a wide variation. Though the technique, which is called the pixel count method, is highly quantitative, it is quite troublesome as it needs the computer to count out each pixels. On the other hand, the linear measurement method is easier than the pixel count method, but is far less quantitative. We examined seventy four subjects using both the linear measurement method and the pixel count method, and compared them by means of the multivariant analysis. Three different linear measurement methods were selected by the stepwise multiple regression analysis, those are B (distance between the caudate nuclei), E (greatest distance between the lateral ventricles at the level of the cella media) and G (number of visible sulci whose width are more than 3.1 mm at the level of 3 cm above the corpus callosum). B and E were calibrated by the maximum internal width of the skull (H). The highest correlation was achieved with a formula employing these parameters as follows; y = 42.66 X B/H + 12.52 X E/H + 0.232 X G - 2.92 (y means the estimated value of the CCR (CSF-cranial ratio), which is obtained by dividing the CSF volume by the cranial cavity). Multiple correlation coefficient was 0.76, and was statistically significant (p less than 0.001). The authors emphasized that using this formula we can easily predict CCR as the index of the brain atrophy without any computer.

Adult↗

The detection of disease clustering in time.

This paper presents a new index for the level of disease clustering in time, which is devised to the case where the data are grouped into several equally spaced intervals. This index is applicable to both temporal and cyclical clustering. The asymptotic distribution of this index is derived under the null hypothesis of no clustering in time. Monte Carlo simulation studies show that the asymptotic results are good approximations when the sample size is as small as the number of intervals, an average of one per interval. The powers of the test based on this index for both types of clustering are compared with those of several existing procedures. Tables of upper percentage points of this index are given.

Disease Outbreaks↗

Prediction of the development of cerebral palsy from perinatal risk factors.

Perinatal data of 29 cerebral palsy (CP) children and 237 control children were analyzed to identify etiological and predictive factors for cerebral palsy. Obstetrical and neonatal factors associated with CP in the low-birth-weight group were sex (male) and place of birth, and in the normal-birth-weight group they were prolonged delivery, meconium staining of the amniotic fluid, an Apgar score of less than 4 at 1 minute, the first respiration occurring only after 3 minutes, and the first cry taking place after 7 minutes. The following neonatal signs and symptoms were strongly associated with CP in the both birth weight groups; convulsion, hypotonia, hypertonia, absence of the Moro reflex, tremor, and apnea. A linear discriminant function was developed from the above neonatal signs and symptoms. The use of three factors, convulsion, hypotonia, and apnea efficiently discriminated between the CP and control children and they would be used as good predictive factors for cerebral palsy.

Apgar Score↗