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Biomedical subjects

T Tanahashi

Publications and source records attributed to T Tanahashi.

At least 109 records · Page 6Linked to original sources
PubMed1985

[Phase II study of recombinant human leukocyte A interferon on urogenital cancer patients].

A phase II study on recombinant human leukocyte A interferon (rIFN-alpha A) was carried out in 30 patients with urogenital cancers. Each patient received rIFN-alpha A by i.m. injection every day for at least 4 weeks. The initial daily dose was 3 X 10(6) U, being escalated at intervals of 3 days or more up to 50 X 10(6) U. The results are summarized as follows: In aged patients, the daily dose appropriate for everyday i.m. injection was considered to be 9 X 10(6) U or below, judging from the adverse reactions observed. According to Koyama and Saito's response criteria, partial response (PR) and minor response (MR) were obtained, respectively, in 3 and 1 out of 12 patients with renal cell carcinoma, while PR was seen in 1 out of 9 with urothelial cancer. No response was observed in patients with testicular cancer and in those with prostatic cancer. Various kinds of adverse reactions were recognized and each patient showed one reaction or more. Fever, fatigue, leukopenia, anemia, thrombocytopenia and elevation of GOT and GPT were observed relatively frequently. Among these, fatigue and thrombocytopenia were regarded as dose limiting factors.

Adult↗
PubMed1985

Carcinosarcoma of the urinary bladder. Report of a case with electron microscopy and review of the literature.

A case of carcinosarcoma of the urinary bladder in a 33-year-old man is presented. The tumor developed from the left anterolateral wall and protruded into the vesical lumen. The excised tumor revealed that more than 99% was sarcomatous component with the appearance of an osteochondrosarcoma. Small foci of papillo-tubular carcinoma were scattered in the sarcomatous area. The histological features, histogenesis and treatment of carcinosarcoma of the bladder are discussed in relation to the literature.

Adult↗
PubMed1982

Effects of steroid sex hormones and adriamycin on human bladder cancer cells in culture.

The effects of steroid sex hormones on the established cell lines derived from human urinary bladder cancer, T24, and from human transitional cell cancer of the urinary tract, 253J, were examined using the colony formation method. Of the seven kinds of steroid hormones tested, estradiol-17 beta was intensively cytotoxic for both cells. The cytotoxic effect was depended on the dose and time of treatment. The combined effect of Adriamycin and estradiol-17 beta on T24 cells could be recognized at low concentrations of Adriamycin (less than or equal to 10(-3) micrograms/ml) after exposure for 24 h.

Aged↗
PubMed1980

Mechanical and neural interactions between binaurally applied sounds in cat cochlear nerve fibers.

Most single fibers of the cochlear nerve (CN) in 22 cats exhibited effects of mechanical interaction in one cochlea between two sounds applied binaurally, similarly to results in two cats in which the contralateral CN was transected. In 11 of 189 fibers, the spontaneous and/or the sound-evoked activity was suppressed by a contralateral intense best-frequency sound; this indicates an interaural neural inhibition, probably through the olivocochlear bundle (OCB). The inhibited fiber population was small, and the intensity differences between the binaural sounds were exceptionally large, so that a simple negative feed-back function via the OCB is not likely.

Acoustic Stimulation↗
PubMed1980

The effects of intravesical instillation of Thio-Tepa on the recurrence rate of bladder tumors.

Seventy-eight patients were treated with intravesical instillation of Thio-Tepa in an attempt to prevent postoperative recurrences of bladder tumors. Fifty-six patients who were given no preventive treatment against recurrences were taken as the control group. The patients in this series presented at the Okayama University Hospital between 1961 and 1976 and only the first recurrence after the primary operation was taken into consideration. There was no significant difference in the recurrence rates of the control and instillation groups.

Adolescent↗
PubMed1979

A method for macroscopic assessment of countries' receptivity to cholera.

It was shown possible to assess macroscopically countries' receptivity to cholera through the use of two commonly available socio-economic indicators. The indicators used were per capita GNP and population density per km2 of inhabitable area. These are related respectively to two major determinants of cholera receptivity: standard of living and population congestion. The global assessment of cholera receptivity indicated the seriousness of cholera as a public health problem in Africa and Asia. It also showed that cholera epidemics are a potential danger to a majority of the population of Latin America.

Cholera↗