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T Tamiya

Publications and source records attributed to T Tamiya.

At least 127 records · Page 7Linked to original sources
PubMed1985

A histological study of surgical landmarks for the specialized atrioventricular conduction system, with particular reference to the papillary muscle.

Surgical landmarks of the conduction system were histologically evaluated in 29 cardiac specimens. The distribution of the system was grossly inherent to the type of ventricular septal defect as classified by Soto and coworkers, although it varied individually. The relationship of the right bundle branch (RBB) to the papillary muscles was of surgical interest. In defects unrelated to maldevelopment of the septum of the conus, the RBB passed beneath or slightly anterior to upper accessory papillary muscles (AcPMs) and posterior to the medial papillary muscle (MPM), regardless of the subtype of defect. In defects caused by maldevelopment, such as tetralogy of Fallot, it passed anterior to the MPM. Such data support the hypothesis that the RBB descends beneath or anterior to embryological upper AcPMs, whatever the morphological role may be, because of the supposedly independent developmental origin of the MPM and AcPMs. The relationship between the RBB and upper AcPMs appeared further modified by the attitude of the trabecula septomarginalis. Our improved clinical results have demonstrated that such information offers a gross but practical guide for prevention of conduction disturbances.

Aged↗
PubMed1985

Cloning and sequence analysis of the cDNA encoding a snake neurotoxin precursor.

A recombinant plasmid has been constructed containing a sequence of 186 nucleotides encoding a potent neurotoxin found in the venom of the sea-snake Laticauda semifasciata and designated as erabutoxin a. This sequence is flanked, in the upstream region, by a sequence of 60 nucleotides encoding a hydrophobic peptide fragment presumably involved in the secretion process of the neurotoxin. The sequence coding for the toxin ends with a termination codon which is followed by a 3'-untranslated sequence of approximately 240 nucleotides (excluding the poly(A) tract).

Amino Acid Sequence↗
PubMed1985

[A case of cerebellar ganglioglioma in an infant--immunohistochemical study].

Ganglioglioma is a rare brain tumor which occurs in an infant and young adult. The term "ganglioglioma" was originally proposed by Ewing in 1926 and subsequently adopted by Courville in 1930. Histogenesis of ganglioglioma is still speculative, but the hypothesis that ganglioglioma is derived from hamartomatous sympathetic neurons is generally thought to be probable. Gangliogliomas of the brain arise frequently from the temporal lobe, frontal lobe, cerebellum and spinal cord. Its growth is gradual and clinically it is a benign tumor, but its malignant transformation has been reported. Ganglioglioma is a tumor composed of both neuronal and glial cells, but the ratio of these two-cell components varies a great deal from case to case and in different areas even of the same tumor. The authors experienced a cerebellar ganglioglioma in an infant which was successfully removed. Histopathological and immunohistochemical studies of the biopsy specimen have been done. That is, histopathological staining with H-E (hematoxylin eosin), PTAH (phosphotangustic acid hematoxylin), cresyl-violet and Bodian, and electron microscopical studies were performed. Also the authors immunohistochemically examined the presence or absence of GFAP (glial fibrillary acidic protein), NSE (neuron specific enolase), S-100 alpha and beta subunits. Histopathologically, the authors could find nerve fiber, glial fiber and identify neuronal cells which had Nisslgranules in the cytoplasm. Electron microscopically the authors could distinguish the neuronal cells which had large nuclei and prominant nucleoli from the glial cells which had processes filled with intermediate glial filaments.(ABSTRACT TRUNCATED AT 250 WORDS)

Cerebellar Neoplasms↗
PubMed1985

[Clinical research on prevention of recurrence of superficial bladder cancer--comparative study on clinical efficacy of bleomycin intravesical instillation and bestatin].

Objectives and methods of the study: Although superficial bladder carcinoma can be surgically eliminated by TUR, recurrence is common. Various attempts have been made to prevent recurrence, but to date an excellent prophylactic method with few adverse reactions has not been established. We conducted a clinical trial study for prophylaxis of bladder carcinoma recurrence, using intravesical instillation of bleomycin, a drug which cause little local irritation, in combination with bestatin, a recently developed immunomodulator. Bleomycin was selected on the bases of experimental results. That is, in beagle dogs, the 1-hour intravesical instillation of bleomycin gained a drug concentration in the bladder wall of 2.08 micrograms/g, which is approximately 4 times higher than that in the intravenous administration of the same dose. The above bleomycin concentration was thought enough to obtain a good clinical effect. A total of 124 patients were randomly divided into the two treatment groups: An only bleomycin intravesical instillation group (60 mg on each treatment day) (58 patients) and a bleomycin with bestatin (60 mg per every day) group (66 patients). In the 2-year follow-up period the recurrence of bladder carcinoma in the two treatment groups was studied. Analysis of non-recurrence rate by life-table method and Kaplan-Meier method: The non-recurrence rate of the bladder carcinoma every three months was calculated by the life-table and Kaplan-Meier methods. The non-recurrence rate in the bleomycin group was approximately the same as the rates in adriamycin or mitomycin reported in the literature. In the bleomycin + bestatin group, the recurrence rates at 9 months and 12 months were significantly (at P = 0.09 and P = 0.08, respectively) lower, and in addition, even the 2-year overall non-recurrence rate curves showed a nearly significant difference (P = 0.179). Especially in the case of papillary pedunculated tumors, the difference in the non-recurrence rate curves was almost statistically significant (P = 0.104). The stratified analysis on the basis of various tumor factors, were as follows. Pathological grade: Although no differences were found in Grades 1 and 2, the bleomycin + bestatin group had a lower recurrence rate in Grade 3 cases (P = 0.1).(ABSTRACT TRUNCATED AT 400 WORDS)

Adolescent↗
PubMed1985

Effects of MT-141, a new cephamycin antibiotic, on acute urinary tract infections.

The bacteriological efficacy of MT-141, a new cephamycin antibiotic, was compared with that of cefotaxime and latamoxef in women with acute simple urinary tract infections, to assess the rapid bactericidal properties of MT-141. MT-141 was less active in terms of its MICs than cefotaxime or latamoxef against the clinical isolates, but MT-141 brought about higher rates of decrease in bacterial counts than cefotaxime or latamoxef within the first hour after injection.

Adult↗
PubMed1985

Comparison of rapid bacteriological response to MT-141 and latamoxef in complicated urinary tract infections.

To assess the rapid bactericidal properties of MT-141, a new cephamycin antibiotic, bacteriological response to MT-141 and latamoxef was compared in complicated urinary tract infections. Although MT-141 was less potent in terms of its MICs than latamoxef against bacterial isolates and was eliminated more slowly than latamoxef from the kidney, MT-141 gave a greater rate of decrease in urinary bacterial counts than latamoxef 6 hours after administration.

Adult↗
PubMed1985

[A histologic study on "surgical landmarks" of the specialized conduction system, with particular reference to the adjacent structure].

The conduction system in 29 cardiac specimens was histologically investigated as to the course and its surgical landmarks. The course varied individually, but was relatively inherent to the type of ventricular septal defect (VSD) (classification by Soto, et al.). The His bundle distributed as reported hitherto. Interesting features were noted in the relationship between the right bundle branch (RBB) and its adjacent papillary muscles. Our definition used for certain papillary muscles is merely to point the topographic site. The RBB ran beneath or slightly anterior to upper accessory papillary muscles (AcPMs) or uppermost AcPM, regardless of the type of perimembranous VSD. It ran posterior to the medial papillary muscle (MPM), with wider variation. In tetralogy of Fallot (TOF), it ran beneath or slightly anterior to the MPM. Relationships described above may be unitarily expressed as below, providing that Van Mierop's embryologic hypothesis on the conus defect anomaly (i.e.,: the uppermost AcPM being often morphologically interpreted as the MPM) is valid: -"The RBB runs beneath or slightly anterior to the upper(most) AcPM, regardless of the type of VSD. Such an arrangement was often observed in other anomalies too. The relationship between the RBB and upper or uppermost AcPM was modified by the attitude of the trabecula septomarginalis. Informations thus obtained have significantly lowered conduction disturbances in our experience.

Aged↗
PubMed1985

Tension pneumocephalus following surgical evacuation of chronic subdural hematoma.

A case among 23 consecutive cases of chronic subdural hematoma developed tension pneumocephalus following surgical evacuation via a burr hole under local anesthesia. A closed drainage system applied into the subdural space was considered to be responsible for its formation as a result of one-way valve mechanism. In all 23 cases, preoperative and postoperative CT scans were reviewed in order to evaluate clinical significance of air in the subdural space after surgery. Air was noticed in all cases with various amount. However, unless the mass effect by air was more than the mass effect by chronic subdural hematoma, it was not necessary to remove air regardless of its amount.

Adolescent↗
PubMed1984

Resection of cancer of the thoracic esophagus without thoracotomy.

We developed a new surgical technique to manually resect the thoracic esophagus without thoracotomy and employed it in 31 patients with cancer of the esophagus who were considered poor risks for resection by traditional thoracotomy. Postoperative complications consisted of left hemothorax in seven patients, hoarseness in five, sternal osteomyelitis in three, a perforated trachea in one, and cardiorenal failure in three patients. No severe pulmonary complications occurred, and there were no hospital deaths. The long-term results of this surgical treatment have not been assessed.

Aged↗
PubMed1983

Effect of synthetic Lys-Trp on adenosine triphosphatase activity of carp and rabbit myosin Bs.

1. With carp myosin B ATPase, the acceleration effect was found at peptide concentration ranging between 1 nM and 1 mM with a maximum at 10 nM (30% acceleration) at the low myosin B concentration (0.2 mg/ml). At the high myosin B concentration (0.8 mg/ml) a maximum was observed at 1-10 mM (10% acceleration). 2. With rabbit myosin B ATPase, the acceleration (10%) was found only at a microM of Lys-Trp in the case of low myosin B concentration (0.2 mg/ml). Under the high concentration of rabbit myosin B, a maximum acceleration (150%) was found at 5 mM of the synthetic Lys-Trp. 3. Effect on superprecipitation was tested only at the high concentration of rabbit myosin B (0.8 mg/ml). The acceleration increased with increasing concentration of Lys-Trp up to 10 mM.

Adenosine Triphosphatases↗
PubMed1982

Clinical appraisal of his bundle electrocardiogram taken under cardiotomy in congenital heart disease.

The specialized conduction system in the heart was electrophysiologically delineated under cardiotomy in 74 patients with congenital heart disease primarily to determine the topographic relationship of the conduction system to intracardiac structures. Histological study was also done to evaluate the electrophysiological data. Differences were found between the ordinary ventricular septal defect (VSD), inlet-type perimembranous defect, and the ordinary tetralogy of Fallot (TOF), outlet-type perimembranous defect. A superficial run of the His bundle along the lower rim summit of defect was often demonstrated electrophysiologically in large VSD of types II or III, whereas the bundle took marked leftward course in TOF. The right bundle branch (RBB) ran beneath or slightly posterior to the Lancisi equivalent structure (LES) in VSD, while it ran under or slightly anterior to LES in TOF. This papillary muscle could be a rough landmark of the RBB. The course of the RBB in TOF, however, had to be histologically confirmed, since its deep location made electrophysiological delineation difficult. All the sites with a high deflection were the areas where the conduction system was histologically demonstrated beneath the endocardium.

Adolescent↗
PubMed1982

The TM bubble oxygenator: development and clinical application.

A bubble oxygenator (the TM or the OCVC oxygenator) has been produced with development efforts focused particularly on reduction of the nonphysiological characteristics of this type of oxygenator. The structural features of the apparatus are: (1) a reduction to the minimum of adequate priming volume, (2) an oxygen disperser designed to ensure evenly dispersed, uniform-sized bubbles, (3) a volume-control system for the oxygenating chamber (the OCVC system) based on extensive experimental oxygenation studies, and (4) an integrated double microfilter of the gravity-drainage type. Clinical features are: (1) ease of operation in perfusion, (2) reduction in hemolysis and postoperative blood loss, and (3) fewer complications associated with microemboli. Clinical use on over 200 infants and children proved generally very satisfactory. The background of its development is briefly described as are future modification plans.

Cardiac Surgical Procedures↗
PubMed1982

Electrophysiological delineation of the specialized conduction system under cardiotomy and its clinical role.

Electrophysiological delineation of the specialized conduction system was performed under cardiotomy on 64 patients: 51 with ventricular septal defect (VSD), 11 with tetralogy of Fallot (TOF) and 2 with transposition of the great arteries (TGA, III). Some histological study was done for confirmation. In large VSD of type II or III, superficial location of the His bundle was shown by a tall H deflection recorded along the inferior rim, coinciding with a high incidence of conduction disturbance in this malformation. One characteristic in TOF was a deflection recorded along the posteroinferior rim rather exclusively on the left ventricular side, coinciding with the anatomic course of the His bundle. A deflection was frequently recorded at an area a few mm posterior to the muscle of Lancisi (ML) or the Lancisi equivalent structure (LES); it was relatively common in ordinary types of VSD, and presumed as the penetrating site of the right bundle branch (RBB) and/or near the bifurcated portion of the His bundle. The second portion of the RBB was not clearly delineated in general, particularly in TOF, but always found within the septomarginal trabecle when delineated. Our conclusion, together with histological study, was that one may use the ML or the LES as a rough marking for the course of the RBB. By this recognition, the surgically induced complete right bundle branch block has been diminished significantly. Variation of the course of conduction system as well as limits of this diagnostic measure are described herein.

Adolescent↗