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T Tamiya

Publications and source records attributed to T Tamiya.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

Nonsurgical treatment of posterior fossa epidural hematoma.

The recommended treatment for posterior fossa epidural hematoma has been prompt surgical evacuation. We report 2 patients who were treated conservatively. Both patients were younger than 10 years of age and developed subacute symptoms and signs. Serial computed tomography demonstrated complete resolution of the hematomas and no development of hydrocephalus during nonsurgical treatment. They recovered well without any neurologic deficits. In order to evaluate an indicative factor for nonsurgical treatment in young children with posterior fossa epidural hematoma, we review both of our patients and 36 well-documented patients from the literature, all of whom were younger than 10 years of age. The results demonstrate that the development of hydrocephalus is a critical factor in clinical progression. Nonsurgical management can be applied in these circumstances until spontaneous resolution of the hematoma unless early signs of medullary compression appear acutely after head trauma or serial computed tomography demonstrates the development of hydrocephalus followed by medullary compression.

Child↗
PubMedDate not supplied

Accumulation of cell cycle regulatory proteins, p21 and p27, induced after hyperthermia in human glioma cells.

It was investigated whether there was a relationship between p53 p21 and p27 induction pathways in the cellular response of glioma cells to hyperthermia. Two glioma cell lines were employed. A-172 cells had the wild-type of p53, and U251 cells had the mutant-type of p53. An adenovirus harbouring wild-type p53 was also used for the overexpression. The protein induction by hyperthermia was monitored by Western blot analysis. In U251 cells, the expression of wild-type p53 and hyperthermia had an additional cytotoxic effect, but did not affect A-172 cells. Significant p21 accumulation by hyperthermia was recognized in A-172 cells, and was also recognized in p53-transduced U251 cells. On the other hand, the accumulation of p27 by hyperthermia was not seen in A-172 or U251 cells, and the exogenous expression of p53 did not affect the accumulation of p27 by hyperthermia in U251 cells. These findings suggest that the p53-p21 pathway is involved in the signal transduction after hyperthermia, rather than the p27 pathway.

Adenoviridae↗
PubMedDate not supplied

Effect of nucleotide and nucleoside mixture on rats given total parenteral nutrition after 70% hepatectomy.

After partial hepatectomy rats were used as a model of patients with liver tumor after extensive hepatectomy. Supplementation of a nucleotide and nucleoside mixture to the total parenteral nutrition solution in rats after 70% hepatectomy resulted in earlier restoration of the nitrogen balance in the first 3 days than the solution without this supplementation. This supplementation had no unfavorable effects on the compositions of the blood and urine, and particularly the metabolites of nucleic acids such as uric acid, beta-alanine, and beta-aminoisobutyric acid. A suitable ratio of nucleotides plus nucleoside to amino acids was tentatively concluded to be 1:2 g N with a calorie supply of 400 kcal.

Animals↗
PubMedDate not supplied

Effects of total parenteral nutrition with nucleoside and nucleotide mixture on D-galactosamine-induced liver injury in rats.

The effect of a nucleoside-nucleotide mixture on liver injury of rats induced by D-galactosamine was studied by examining changes in function and histopathology of the liver. Animals with liver damage received total parenteral nutrition with glucose and amino acids supplemented with a nucleoside-nucleotide mixture containing inosine, cytidine, GMP, uridine and thymidine, or with uridine which inhibits galactosamine injury, or with liver cell extract containing flavin adenine dinucleotide and nucleic acid derivatives. As control, animals with liver damage received total parenteral nutrition with glucose and amino acids only. The serum GOT and GPT concentrations were significantly lower in the group supplemented with nucleoside-nucleotide mixture than those in other groups. A large dose (1.2 g/kg) of uridine inhibited liver injury, but a lower dose (0.14 g/kg) did not have any effect, whereas nucleoside-nucleotide mixture containing the same amount of uridine inhibited the injury. Liver cell extract also did not improve liver function. Thus infusion of a physiological and balanced mixture of nucleosides or nucleotides may improve liver function in rats with liver injury.

Animals↗
PubMedDate not supplied

The effect of tricaprylin emulsion on protein turnover in scald burn rats.

Recently, the beneficial effects of administration of medium chain triglyceride (MCT), such as rapid oxidation and the efficient nitrogen sparing effect under severe stress, have been reported by many investigators. This experiment was designed to evaluate the effect of tricarpylin ++ on protein metabolism in comparison with long chain triglycerides (LCTs). Male Wistar rats weighing about 200g received scald burns on 25% of their body surface area and were given total parenteral nutrition (TPN) (228kcal/kg/day, 1.8g/kg/day of nitrogen) for 3 days. For the tricarpylin and the LCT groups, 50% of nonprotein calorie (NPC) was supplied with each lipid emulsion, and for the control group NPC was supplied with glucose alone. After TPN, the rate of protein turnover was measured by the method of Picou and Taylor-Roberts. Nitrogen balance, ketone bodies, albumin, glutamic oxaloacetic transaminase (GOT), and glutamic pyruvic transaminase (GPT) were also measured. The daily nitrogen balance was significantly more improved in the tricaprylin group than in the LCT and control groups. The rate of protein synthesis was higher than the rate of protein breakdown in the tricaprylin group. There was no significant difference in blood ketone bodies among the three groups. GOT and GPT levels increased in the LCT and the control groups but remained within the normal range in the tricaprylin group. There was no significant difference in blood ketone bodies among the three groups. GOT and GPT levels increased in the LCT and the control groups but remained within the normal range in the tricaprylin group.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMedDate not supplied

Effect of a nucleoside-nucleotide mixture on protein metabolism in rats after seventy percent hepatectomy.

The effect of a nucleoside-based mixture (OG-VI) on protein synthesis in partially hepatectomized rats was evaluated. Twenty male Wistar rats weighing about 200 g underwent 70% hepatectomy by Higgins and Anderson's method, and then were subjected to total parenteral nutrition (TPN) for 3 days: the control group received only standard TPN (S-TPN group) and the experiment group received standard TPN supplemented with a nucleoside-nucleotide mixture (13% W/V, OG-VI) (OG-TPN group). The rates of whole body protein turnover and protein synthesis and breakdown were determined for 3 days after hepatectomy by the method of Picou and Taylor-Roberts with [15N] glycine. The nitrogen balances on days 1 and 3 and the cumulative nitrogen balance were significantly higher in the OG-TPN group than in the control group. Moreover, the rates of protein turnover and protein synthesis were significantly higher in the OG-TPN group than in the control group. Thus, increase in protein synthesis, rather than change in protein breakdown, was concluded to be responsible for the better nitrogen balance of the OG-TPN group. These findings suggest that the nucleoside-nucleotide mixture was used for the syntheses of RNA and DNA through the salvage pathway in regenerating liver and that this resulted in enhanced protein turnover with simultaneous increase in protein synthesis.

Animals↗
PubMedDate not supplied

Electrophysiological delineation of the specialized conduction system during cardiotomy and its clinical appraisal.

The specialized conduction system was delineated electrophysiologically during cardiotomy, primarily to discover the topographic relations between the conduction system and the intracardiac structures. A series of 72 cases operated on for congenital cardiac anomalies was studied. A superficial location of the His bundle along the lower rim of the defect was often noticed in cases of large ventricular septal defect (VSD) of type II or III, whereas a marked leftward deviation was noted, in cases of tetralogy of Fallot (TOF). Significant deflections were commonly recorded on the tricuspid annulus a few mm below the defect, and frequently on the lower rim behind the muscle of Lancisi (ML) in both VSD and TOF (left ventricule side in TOF). Particular care should be taken in these areas, during closure of any defect. The ML was found to be a rough landmark for the right bundle branch, although topographic relations were slightly altered according to the type of disease. The change may also depend on whether the perimembranous defect is of the inlet- or outlet-type.

Adolescent↗