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Biomedical subjects

T Takeuchi

Publications and source records attributed to T Takeuchi.

At least 1,477 records · Page 82Linked to original sources
PubMed1988

Antitumour activity of new semi-synthetic anthracyclines containing fluorotalopyranose.

The authors have synthesized 7-O-(2,6-dideoxy-2-fluoro-alpha-L-talopyranosyl) adriamycinone (FT-ADM) which exhibited strong antitumour activity and weak toxicity. These characteristics of FT-ADM are partly due to the presence of a 2'-fluoro atom which strengthens the glycoside bond. FT-ADM, however, is sparingly soluble in water because of lack of the 3'-amino group of adriamycin. To increase the solubility of FT-ADM, a hydrophilic group was added at the 14-OH group. Then, the 14-hemisuccinate, 14-hemiglutarate, 14-hemiadipiate, 14-hemipimelate and 14-hemisuberate derivatives of FT-ADM were synthesized. Among them, the 14-hemipimelate derivative (FAD-104) was selected for further development because of its potent antitumour activity and weak toxicity. When drugs were injected intraperitoneally every day from day 1 to 9, FAD-104 showed an apparently stronger antitumour effect against mouse L-1210 leukaemia than adriamycin with lower toxicities. FAD-104 was also more effective than adriamycin on L-1210 using other administration schedules. A characteristic feature is that FAD-104 is effective over a very broad range, which will be advantageous for safe clinical use. FAD-104 also showed marked antitumour effect against L-1210 when it was injected intravenously either once on day 1 or three times on days 1, 5 and 9. Thus, FAD-104 may be a more potent antitumour anthracycline than adriamycin.

Animals↗
PubMed1988

Biological properties of ME2303 (FAD-104), a new anthracycline.

ME2303 (FAD-104) is a new anthracycline antibiotic whose structure is characterized by the presence of a 2'-fluoro atom and the lack of a 3'-amino group in the sugar moiety. Its cytocidal activity is superior to or equal to that of adriamycin (ADM). The LD50 value of ME2303 was about 140 mg/kg i.v. in mice and this value was about 7-fold higher than that of ADM. ME2303 was administered intravenously to Golden strain hamsters at doses of 25, 50, 75 and 150 mg/kg and the ECG was examined. From ECG changes, it seems that ME2303 did not show any effect on the heart in acute toxicity. Mutagenicity was recognized as with ADM in the back-mutation test.

Animals↗
PubMed1988

[Ultrasound-guided puncture for renal cyst and instillation of povidone iodine].

Percutaneous puncture followed by instillation with 10% povidone iodine was performed on 23 patients with benign renal cysts. All patients showed remarkable reduction (mean: 86.6%) in size of renal cyst on sonography or computed tomography within a short time (mean: 143 days). Twelve (85.7%) of the 14 symptomatic patients due to the disease were relieved of subjective symptoms such as lumbago after instillation. In a 71 year-old man, microscopic hematuria disappeared after this treatment. There were no complications with this treatment except in one patient who suffered from perinephritis due to a technical problem. This treatment seems to be a safe and effective way to prevent recurrence of cystic fluid.

Adult↗
PubMed1988

[A case of superselective transcatheter embolization for injured renal segmental artery associated with percutaneous nephroureterolithotomy (PNL)].

A case in which the renal segmental artery was injured due to percutaneous nephroureterolithotomy (PNL) and treated by superselective transcatheter embolization is reported. The patient was a 30-year-old man with left ureteral and bilateral renal calculi. The left renal and ureteral calculi were successfully removed by PNL and a 24Fr. nephrostomy catheter was placed for 8 days after PNL. A few minutes after removal of the nephrostomy catheter, arterial bleeding, which seemed to occur due to injury of renal segmental artery associated with PNL, began. The bleeding was stopped by replacement of a 24Fr. nephrostomy catheter and the patient received 5 units of packed red blood cells. Six days after hemorrhage, superselective transcatheter embolization was performed. No further bleeding occurred and the nephrostomy catheter was removed 2 days later without any incident. This interventional technique is safe and useful to control bleeding from renal segmental artery injured by PNL.

Adult↗
PubMed1988

[Perianal skin metastasis in a case of lung cancer].

A case of lung cancer in a 78-year-old man who subsequently developed a perianal skin metastasis is herein reported. The metastatic lesion was the fist clinical metastatic sign noticed. Although irradiation therapy reduced the size of the lung tumor, the tumor soon regrew and the patient died of massive hemorrhaging from the perianal mass. An autopsy revealed that the primary tumor and all metastases were, histologically, a mucoepidermoid carcinoma. A metastasis of a lung cancer to the perianal region is extremely rare, only one case involving an anaplastic carcinoma having been previously reported.

Aged↗
PubMed1987

[Centrifugal ultrafiltration method for determining the percent of free testosterone in serum].

Serum free testosterone (T) % in the follicular phase of 11 normal women, 11 normal men and 30 pregnant women of 5 to 39 weeks of gestation were determined by the centrifugal ultrafiltration method (CUF), which was performed at the centrifugation of 5 minutes, 1000 g and 37 degrees C, using the Amicon MPS-3 and YMT membrane. These conditions were shown to be appropriate for measuring the free T. There was a significant correlation between the percentage of free T due to the CUF and the equilibrium dialysis method (ED) (r = 0.88, p less than 0.01). Serum free T % and free T concentrations by the CUF method were, respectively, 2.89 +/- 0.09 (SE) % and 166.3 +/- 9.8 pg/ml in normal men, 1.76 +/- 0.09% and 9.4 +/- 0.7 pg/ml in non-pregnant women and 1.14 +/- 0.03%, 22.4 +/- 1.4 pg/ml in pregnant women. Serum free T % in non-pregnant women was significantly lower than in men (p less than 0.001) and higher than in pregnant women (p less than 0.001). In the CUF method the intra-assay CV was 4.9% in women, 6.0% in men and the inter-assay CV was 5.1% in women, 6.2% in men. The CUF method was more simple, rapid and accurate on the determination of the free T in serum than the ED method.

Centrifugation↗
PubMed1987

An enzyme immunoassay for pepsinogen II(PGII): chronological changes in serum PGII concentrations.

A new two-site enzyme immunoassay for pepsinogen II(PGII) has been developed. The detection limit of PGII was 0.15 ng/ml (15 pg/tube) and the optimal assay range was 1.5 to 150 ng/ml (150 pg to 15 ng/tube). Mean serum PGII concentrations in normal males and females were 17.2 and 14.6 ng/ml, respectively. The chronological analysis among 5 age groups from 20 to 69 yr, males and females together, revealed that the serum level was low (11.9 ng/ml) between 20-39 yr, gradually increased from 40 yr of age and attained the maximum (22.5 ng/ml) in the 50-yr group. Total gastrectomy markedly lowered the serum level to 1.9 ng/ml, suggesting that the majority of PGII in serum was derived from the gastric mucosa. This assay makes it possible to measure trace amounts of PGII derived from extragastric as well as gastroduodenal tissues.

Adult↗