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Biomedical subjects

T Takemoto

Publications and source records attributed to T Takemoto.

At least 127 records · Page 7Linked to original sources
PubMed1988

[Endoscopic therapy of early gastric cancer by strip biopsy].

Strip biopsy is carried out in accordance with the principle of endoscopic injection and polypectomy. By using strip biopsy, the full thickness of the mucosa is removed, including the submucosal layer, largely without risk, even in cases of depressed or flat lesions. We have applied this procedure to the therapy of early gastric cancer. Its most valuable aspect is that the resected tissue is collected and the efficacy of the therapy can be evaluated from both macroscopic findings and histological sections. We have applied strip biopsy in 133 cases involving 137 lesions of 8 early gastric cancer, of which 65.0% were totally resected using only the strip biopsy technique. Other cases were treated surgically or subjected to additional endoscopic therapy. sixteen cases were confirmed to have been perfected resected by stomach surgery. Another 71 patients who were not candidates for surgery because of their physical condition have been followed endoscopically for 2 to 48 months, but there has not been any recurrence. On the basis of this study, we believe that the strip biopsy therapy of early gastric cancer should be evaluated in addition to surgical therapy, especially in cases of small lesions localized only in the mucosa.

Biopsy↗
PubMed1987

Clinical evaluation of glucagon and insulin in therapy of fulminant hepatitis.

Forty five patients were examined in order to evaluate the usefulness of glucagon and insulin as a therapy of fulminant hepatitis. Thirty patients were treated with simultaneous infusion of glucagon and insulin, whereas prednisolone was given at a daily dose of 60 to 90 mg in 15 cases. In the former group, 1 mg of glucagon and 10 units of regular insulin were infused over a period of 2 to 6 hours. Two such treatments were given per day in the early critical period of fulminant hepatitis. The therapeutic effect of glucagon and insulin was evaluated in comparison with that of prednisolone, and additionally, with a combination therapy of either blood exchange or plasmapheresis in both groups. The survival rate was superior in the group treated with glucagon and insulin (46%) and in the one with combined infusion of these hormones plus plasmapheresis (33%).

Adult↗
PubMed1987

Effects of ranitidine on plasma clearance of indocyanine green in patients with liver cirrhosis.

The effects of ranitidine on plasma clearance of ICG were investigated in 68 cirrhotic patients (9 were positive for HBsAg, 33 were alcoholics and 26 had cryptogenic cirrhosis). The ICG clearance test was performed before and after ranitidine administration. In 31 patients treated with ranitidine (150 mg perorally), the plasma ICG clearance were 233.6 +/- 20.4 ml/min (mean +/- S.E.) and 239.2 +/- 20.5 ml/min before and after ranitidine, respectively. In the 37 treated with intravenous ranitidine 50 mg, the corresponding values were 205.4 +/- 17.7 ml/min and 206.4 +/- 17.9 ml/min. There was no significant change in the plasma clearance of ICG or the elimination rate constant after ranitidine administration. Even in patients with decompensated liver cirrhosis, no significant change was demonstrated in the plasma ICG clearance after ranitidine. These results led to the conclusions that ranitidine does not reduce the hepatic blood flow and that it is a safe and useful drug for the treatment of gastrointestinal tract bleeding in patients with liver cirrhosis.

Adult↗
PubMed1987

Palliative laser therapy.

Endoscopic laser treatment has been tried for hemostasis, relief of stenosis and reduction of tumor volume in advanced upper gastrointestinal cancer. This form of treatment was found to be effective for each purpose, but success was usually only temporary. Thus, it was considered that endoscopic laser therapy for problems of advanced upper GI cancer could perhaps be improved by modifying the technique and/or developing new methods, such as the combination of the laser with other therapies.

Aged↗
PubMed1987

Distribution of alpha-fetoprotein-producing cells and proliferating cells in human hepatoma cells transplanted into athymic mice.

To clarify the relationship between alpha-fetoprotein (AFP) production and cell growth in hepatocellular carcinoma an immunohistochemical method was used to examine the geographical distribution of AFP-producing cells and DNA-synthesizing cells in hepatoma tissue which was formed by subcutaneous transplantation of the human hepatoma cell line, HuH-7, into athymic mice. DNA-synthesizing cells were localized to the perivascular restricted areas where AFP-producing cells were preferentially demonstrated. The fall of the labeling index of bromodeoxyuridine was accompanied by a decrease in AFP production. The results indicate that AFP is produced mainly by the cells participating in tumor growth but not by quiescent cells.

Animals↗
PubMed1987

Efficacy of sucralfate in the prevention of recurrence of peptic ulcer--double blind multicenter study with cimetidine.

A double blind, multicenter, six-month maintenance study was performed to assess the efficacy and safety of sucralfate (S), cimetidine (C), and their combination (S + C) in the prevention of peptic ulcer recurrence in a six-month observation period. 127 patients with gastric ulcer (GU) (group S: 39, group S + C: 48, group C:40) and 103 patients with duodenal ulcer (DU) (group S: 35, group S + C: 36, group C:32) were available for statistical analysis. Six to 12 months after healing of GU, the cumulative recurrence prevention rates by Kaplan-Meier method were 89.7----80.3% in group S, 97.6----72.6% in group S + C, 84.5----44.6% in group C. In duodenal ulcer they were 75.9----41.9% in group S, 87.8----47.7% in group S + C, 80.8----40.5% in group C. These results indicate that maintenance therapies of S and S + C are effective and safe for the prevention of gastric ulcer recurrence.

Adult↗
PubMed1986

Minute lesions of esophageal cancer.

Fifty-four cases of minute esophageal cancer (1 cm or less in the greatest dimension) were collected and analyzed. Of these 67% were mucosal cancer and 28% were submucosal cancer. Prognosis was anticipated to be good as there was only one case of lymph node metastasis and three of vascular invasion. A lesion of 1 cm can be regarded as curable regardless of its depth of invasion. The endoscopic approach with use of a dye staining technique is useful for detection of or screening for minute esophageal cancer.

Adult↗