Biomedical subjects

T Takazawa

Publications and source records attributed to T Takazawa.

10 recordsLinked to original sources

PubMed1992

[Clinical evaluation of prostaglandin E1 during anesthesia in non-elderly and elderly patients].

The effects of prostaglandin E1 (PGE1) on blood pressure during anesthesia and the postoperative changes in organ functions were examined and compared in 358 cases. Two hundred and eighty patients were under 64 years of age and 128 patients were over 65 years. It was possible to control blood pressure satisfactorily with PGE1 in both non-elderly and elderly groups. However in the elderly group, it was more difficult to control blood pressure with PGE1 under NLA as compared with enflurane anesthesia. In both groups, urinary flow increased during and after the administration of PGE1, and the livers and kidneys showed neither dysfunction nor deterioration after operation. We had very few incidences of side effects with this drug. PGE1 is also considered safe and useful for elderly people during and after surgery.

Adolescent↗

PubMed1991

[The effect of enflurane anesthesia on plasma superoxide dismutase (SOD)-like activity in elderly patients].

Plasma SOD-like activity during enflurane anesthesia was measured according to electron spin resonance in ten elderly patients over 66 years and in nine patients under 64 years. Anesthesia was induced with thiopental 4 mg.kg-1 and succinyl-choline 0.8-1.0 mg.kg-1 intravenously and was maintained with enflurane 1.0-2.0% in nitrous oxide and oxygen. They were ventilated manually throughout the surgery. The mean plasma SOD-like activity before anesthesia was lower in the elderly group compared with the control group. This decreased significantly in the elderly patients on the first and third day after surgery. There was no relationship between plasma SOD like activity and patient age. We conclude that increased superoxide anion production in the post-operative period may affect plasma SOD-like activity.

Aged↗

PubMed1989

[Effects of modified NLA with droperidol and eptazocine and surgery on pituitary-adrenocortical function in man].

Effects of modified NLA with droperidol + eptazocine on pituitary-adrenocortical function were evaluated in ten patients who received abdominal hysterectomy. They were premedicated adequately. The induction of anesthesia was started with eptazocine 30 mg iv and thiopental 3-4 mg.kg-1 iv and the trachea was intubated smoothly following succinylcholine 40 mg iv. Then, they were given intravenous droperidol 0.15 mg.kg-1 with inhalation of 70% N2O and 30% O2. Good intraoperative muscle relaxation was obtained by dialferine or pancuronium. Five ml of the venous blood was taken on six occasions as follows; before the anesthetic induction, 5 and 30 minutes after the induction, 30 and 60 minutes after the start of surgery and finally at full recovery from anesthesia in the recovery room. The blood samples were immediately centrifuged and the plasma was separated and stored at -20 degrees C until measurement. Plasma cortisol, ACTH, human growth hormone (HGH) and prolactin (PRL) were measured for evaluation of the anterior pituitary-adrenocortical function. No significant increase in plasma levels of cortisol, ACTH and HGH were observed during anesthesia alone, but they increased significantly during surgery. Plasma levels of PRL increased significantly soon after the induction. These results were similar to those of other neuroleptic anesthesia. The systemic blood pressure and the heart rate were stable during anesthesia and surgery, and plasma eptazocine concentration determined by GC-MS showed that effective concentrations of eptazocine were maintained during surgery. These data suggest that modified NLA with droperidol and eptazocine would deserve a further detailed clinical study.

Adult↗

PubMed1985