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Biomedical subjects

T Takaki

Publications and source records attributed to T Takaki.

At least 37 records · Page 2Linked to original sources
PubMed1989

Subependymal giant-cell astrocytoma associated with tuberous sclerosis. Do subependymal nodules grow?

A case of a 10 year-old-boy with subependymal giant-cell astrocytoma associated with tuberous sclerosis is reported. Sequential CT scan showed the growth of subependymal nodules to intraventricular neoplasm, which consequently obstructed the CSF pathway. The surgical indications for this lesion and the role of CT in following up subependymal nodules of tuberous sclerosis are discussed.

Astrocytoma↗
PubMed1988

Brain metastasis from urachal carcinoma.

A case of brain metastasis from urachal carcinoma is reported. Originally the source of the tumor was unknown. Histologic diagnosis of resected specimen was adenocarcinoma. Later removal of urachal carcinoma with partial resection of the bladder revealed adenocarcinoma identical to that of the brain tumor.

Adenocarcinoma↗
PubMed1987

Neurinoma of the trigeminal root presenting as atypical trigeminal neuralgia: diagnostic values of orbicularis oculi reflex and magnetic resonance imaging. A case report.

A case of trigeminal root neurinoma presenting as atypical trigeminal neuralgia was reported. The orbicularis oculi reflex was absent on the affected side, but reappeared after operation. The demonstration of the tumor was much clearer on magnetic resonance imaging. The usefulness of these electrophysiological and radiological studies in differentiating varied entities of trigeminal neuralgia is stressed.

Aged↗
PubMed1987

[Therapeutic problems in aged patients with intracranial aneurysms].

In a series of 404 patients with intracranial saccular aneurysm, 61 were over 65 years of age. Ten of these aged patients had no surgery. The operative mortality in the aged patients was 11.8%. While the mortality rate in patients below 65 years was 6.1%. The main complication following intracranial surgery for aneurysm consisted of cerebral infarction due to vasospasm, hydrocephalus, intracranial hematoma and general complications. The incidence of angiographical vasospasm was 22.6% in the aged patients and 43.6% in the young patients. There is no significant difference in vasospasm following subarachnoid hemorrhage between the aged and young patients. Cerebral infarction occurred in 27.5% of the aged patients and in 24.6% of the young patients. Severe cerebral infarction was found in 92.9% of the aged patients and in 58% of the young patients. Vasospasm resulted in broad cerebral infarction significantly more frequently in the aged patients, but cerebral infarction proved was non-fatal in the aged patients. Ventricular dilatation detected by CT was found in 33.3% of the aged patients and in 24.2% of the young patients. In patients with ventricular dilatation, 82.4% of the aged patients needed ventriculo-peritoneal shunt (V-P shunt). On the other hand, 39.3% of the young patients had V-P shunt. There was no significant difference for ventricular dilatation detected by CT between the aged and young patients. The aged patients depended on V-P shunt significantly more than did the young patients.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1983

Possible explanation of radioresistance of glioblastoma in situ.

The response of human glioblastoma to radiation was studied in the logarithmic phase and in the plateau phase of growth, and was compared with those of HeLa S3 irradiated under identical conditions. There was no major difference in the in vitro survival curve parameters between glioblastoma and HeLa in the logarithmic growth phase. However, the surviving fractions for glioblastoma with radiation doses in the range used clinically were higher not only when irradiated in the logarithmic growth phase, but also when subcultured 6 hours after irradiation in the plateau phase, than those for HeLa treated under identical conditions. This suggests that the relatively low cure rate of glioblastoma can be partially explained by the intrinsic radiosensitivity in the logarithmic growth phase and by a high surviving fraction for cells irradiated in the plateau phase.

Cell Survival↗
PubMed1982

[Computation of a radiodosage equivalent of the effect of bleomycin].

The responses of in vitro cultured mammalian cells to X-rays and bleomycin were compared for establishing a general rule to convert X-ray dose to bleomycin dose for a given biological effect. There was no significant difference in the radiosensitivities according to cell lines used in this experiment, while the responses of cells to bleomycin varied from cell to cell. The X-ray dose-response curves for the cells were convex upward if plotted on a semilogarithmical scale, while bleomycin dose-response curves were convex downward. These results indicated that the ratio of X-ray dose and bleomycin dose required for a comparable biological effect would vary with the X-ray dose and from cell to cell. Preliminary treatment with bleomycin sensitized mammalian L5 cells to X-rays. When the cells were exposed to bleomycin following irradiation, no significant synergestic effect was observed, in spite of the fact that the bleomycin dose was sufficient to result in a survival of 4.5%.

Adolescent↗