Biomedical subjects
Publications and source records attributed to T Tacheva.
Aflatoxicosis was induced under experimental conditions in two groups of broiler birds fed in the course of the entire fattening period upon feed, containing 0,250 and 0,600 ppm aflatoxin. Dependable changes were established in the investigated haematological and biochemical indices. There was a drop of the body weight and an increase in the feed to gain ratio. Pathologic changes were recorded in the liver.
Studied were some paraclinical indices of the blood of 50 broiler birds treated with aflatoxin B1. It was found that the effect of the mycotoxin used in concentrations of 25.0 and 37.5 micrograms in the course of thirty days and in conc. of 50.0 micrograms in the course of five days with three test groups of birds (as compared to a group of controls) consisted in the drop of total protein and the rise of the activity of GOT, GPT, and total bilirubin. It was demonstrated that the use of feeds containing aflatoxin B1 had a bearing on the microbiologic status of the meat and liver. There was no increase in the total count of aerobic mesophile organisms.
Studied was the effect of toxic trichotecenes and the F-2 toxin on the health status and the morphologic and biochemical changes in the blood on weaned lambs. It was shown that there was a drop of the hemoglobin content, rise of the leucocyte count, and decrease in the amount of the total proteins along with an increase in the activity of glutamate-oxalacetate and glutamate-pyruvate transaminases, alkaline phosphatase, and lactate-dehydrogenase. The morphologic changes appeared confined to the rumen, lymph nodes of the forestomach, duodenal mucosa, liver, and kidneys.
Experiments were carried out with pigs in the course of 30 days with the use of dietary mixtures containing 10 and 20 per cent cultures of Fusarium tricinctum in rice. The treated animals showed higher sensitivity to trichotecenes. These moulds metabolites raised the activity of the serum glutamate oxaloacetate and glutamate-pyruvate transaminases, aldolase, lactate dehydrogenases, alkaline phosphatase, lipid level, and leukocyte count but lowered the amount of total protein and that of hemoglobin. The morphologic lesions seemed confined mainly to the stomach, intestines, and kidneys.
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