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Biomedical subjects

T Tabata

Publications and source records attributed to T Tabata.

At least 379 records · Page 21Linked to original sources
PubMedDate not supplied

Assessment of right-to-left shunt flow in atrial septal defect by transesophageal color and pulsed Doppler echocardiography.

To investigate the clinical significance and problems of right-to-left (R-L) shunt flow dynamics in atrial septal defects, we performed transesophageal color and pulsed Doppler echocardiography in 30 patients with atrial septal defects of the ostium secundum type. The 30 patients consisted of 20 with a pulmonary artery systolic pressure of less than 40 mm Hg, four with a pressure of 40 to 60 mm Hg, three with a pressure of 90 mm Hg or more, two patients with pulmonic stenosis, and one patient with Ebstein's anomaly. R-L shunting was determined by the presence of a shunt flow signal across the defect during each cardiac cycle. The time of R-L shunt flow was compared with the various parameters obtained by echocardiography and cardiac catheterization. R-L shunt flow signals were detected at the following times: (1) at the onset of ventricular contraction or the closing phase of the tricuspid valve in five patients with isolated atrial septal defect. These patients showed an increase of mean right atrial pressure but had no severe pulmonary hypertension; (2) during ventricular systole in five of 26 patients with tricuspid regurgitation and one patient with Ebstein's anomaly. The tricuspid regurgitant signal was directed toward the ostium of the defect in three patients and was massive in the other patients; (3) during middiastole in three patients without pulmonary hypertension. These patients showed massive left-to-right shunt flow from end systole to early diastole; and (4) during atrial systole in three patients with severe pulmonary hypertension and two patients with pulmonic stenosis. The former, in particular, showed the aliasing signal as a high-speed shunt flow. In two of the three patients with severe pulmonary hypertension, R-L shunting continued from atrial systole to early ventricular systole and was also observed in early diastole. R-L shunt flow was detected in patients with atrial septal defects not only with pulmonary hypertension but also without pulmonary hypertension and was influenced by the right atrial pressure in the phase of tricuspid valve closing, the volume or direction of tricuspid regurgitation, rebound flow caused by massive left-to-right shunt flow, the grade of right ventricular distensibility or the complication of pulmonary hypertension, and complications with other cardiac anomalies. Thus R-L shunt flow in patients with atrial septal defects was detected easily by transesophageal color and pulsed Doppler echocardiography because of the high efficiency of this method for its detection.

Adolescent↗
PubMedDate not supplied

Influence of aging on left atrial appendage flow velocity patterns in normal subjects.

Transesophageal pulsed Doppler echocardiography was performed to examine changes with age in the left atrial appendage flow velocity patterns in 50 normal subjects (15 to 80 years) in sinus rhythm. There was a significant negative correlation between the peak early diastolic forward and backward left atrial appendage flow velocities and age, as well as a significant positive correlation between the peak early diastolic forward left atrial appendage flow velocity and the peak early diastolic transmitral and pulmonary venous flow velocities. Although there was a significant positive correlation between the peak atrial systolic transmitral flow velocity and age, there was a negative correlation between the peak atrial systolic forward and backward left atrial appendage flow velocities and age. There was a positive correlation between both the maximum left atrial diameter and the amplitude of the interatrial septal motion during atrial systole and age. There was a significant negative correlation between the left atrial appendage ejection fraction during atrial systole and age. Left atrial appendage thrombi and spontaneous echo contrast were detected in two subjects with low peak early diastolic and atrial systolic left atrial appendage flow velocities. In conclusion, both peak early diastolic and atrial systolic left atrial appendage flow velocities decreased with age. A decrease in the peak atrial systolic flow velocity appeared to be an important sign of left atrial appendage thrombus formation even in normal elderly subjects in sinus rhythm.

Adolescent↗
PubMedDate not supplied

Influence of left atrial pressure on left atrial appendage flow velocity patterns in patients in sinus rhythm.

To examine changes in left atrial appendage flow velocity patterns in relation to left atrial pressures during sinus rhythm, transesophageal echocardiography and cardiac catheterization were performed in 31 patients with myocardial diseases in sinus rhythm and 20 control subjects without cardiovascular disease. The 31 patients were divided into two groups according to mean pulmonary capillary wedge pressure: the group with high wedge pressure (19.9 +/- 5.8 mmHg) and the group with low wedge pressure (8.6 +/- 2.9 mmHg). The left atrial appendage peak early emptying velocity was decreased significantly in the groups with both high and low wedge pressure compared with the control group. The left atrial appendage peak late emptying velocity was significantly greater in the group with low wedge pressure compared with the control group, whereas it was decreased significantly in the group, with high wedge pressure compared with the control group. The left atrial appendage peak late emptying velocity had a significant negative correlation with wedge pressure. The maximum left atrial appendage area at end systole in the group with high wedge pressure was significantly greater than that in both the group with low wedge pressure and the control group. There was a significant positive correlation between the maximum left atrial appendage area and the wedge pressure, as well as a significant negative correlation between the left atrial appendage ejection fraction during atrial contraction and the wedge pressure. In the group with high wedge pressure, one patient had evidence of left atrial appendage thrombi and two had spontaneous echo contrast. These results suggest that even in patients in sinus rhythm, a marked elevation in the left atrial pressure is likely to reduce the left atrial appendage peak early and late emptying velocities. These changes may be accompanied by an increased incidence of thrombus formation in the left atrial appendage compared with individuals with normal or only slightly elevated left atrial pressures.

Atrial Function↗
PubMedDate not supplied

Immunoglobulin M synthesis after burn injury: the effects of chronic ethanol on postinjury synthesis.

The effect of chronic ethanol ingestion on class-specific immunoglobulin (Ig) synthesis after burn injury was investigated in C57BL/6 mice. Animals were divided into four groups: control, burn, ethanol-sham, and ethanol-burn groups. Five days after injury or the last ethanol ingestion, cell suspensions from spleen and mesenteric lymph nodes were prepared. The number of class-specific Ig-bearing cells were counted by flow cytometry. The cell suspensions were cultured with lipopolysaccharide for 4 days. The supernatants from these cultures were tested for class-specific Ig by enzyme-linked immunoassay. No change occurred in the amount of class-specific IgG and IgA produced by 10(5) lymphocytes calculated from both of these data. Both burn and ethanol alone impaired IgM synthesis; splenic IgM was most affected by burn, and mesenteric lymph node IgM was most affected by ethanol. The group receiving ethanol before burn had IgM synthesis significantly impaired in both lymphocyte populations. Because IgM is the most important Ig in resistance to bacterial infection, this consistent suppression of IgM synthesis in both these tissues may contribute to increased incidence and severity of acute infection.

Alcohol Drinking↗
PubMedDate not supplied

Differences in IgM synthesis to gut bacterial peptidoglycan polysaccharide after burn injury and gut ischemia.

Both burn injury and intestinal ischemia have been proven to induce bacterial translocation from the gut. It is still unknown, however, whether the bacteria induces immune response in these different models. To assess this, we measured in vitro IgM synthesis to peptidoglycan polysaccharide (PGPS), a ubiquitous gut bacterial antigen, after burn injury or gut ischemia-reperfusion in a mouse model. Eighty-five BALB/c mice were divided into four groups. Gut ischemia was produced by placing a vessel loop around the superior mesenteric artery at celiotomy (group Isc; n = 31). After 45 minutes, the abdomen was reopened, and the vessel loop removed. All animals had visible gut ischemia. Control mice (group Isc-C; n = 15) underwent two sham operations. Burn injury was 25% body surface area full-thickness to the dorsum (group B; n = 27). Another control group (B-C; n = 12) was also used. Animals were euthanized 24 hours after recirculation or 5 days after the burn injury. All spleens were removed, and cell suspensions prepared. Cells were cultured in 2.5 micrograms/ml lipopolysaccharide for 5 days, and anti-PGPS IgM level in the supernatant was measured by an enzyme-linked immunosorbent assay. Intestinal ischemia produced a significant rise in in vitro anti-PGPS IgM synthesis per 10(5) lymphocytes, which is the principal immunoglobulin response to infection. However, anti-PGPS IgM in mice after burn injury was significantly decreased. This decreased IgM synthesis after burn injury compared to gut ischemia may represent continued immune impairment from the burn wound, and may account for organ dysfunction related to bacterial translocation after burn injury.

Animals↗
PubMedDate not supplied

Simple calculation of the electron-backscatter factor.

The authors have studied the dependence of the electron-backscatter factor (EBF) on mean electron energy and on backscatterer atomic number by using the semiempirical depth-dose code EDMULT. A plane-parallel electron beam is assumed to be normally incident on a polystyrene slab, which is backed with a layer (backscatterer) of different materials of effectively semi-infinite thickness. A small air cavity to measure ionization is embedded in the polystyrene slab at the boundary facing the backscatterer. The EBF is defined as the ratio of the ionization with the backscatterer to the ionization with a full polystyrene medium, and is approximated by the ratio of the doses computed at the depth of the cavity. Values of EBF obtained show trends similar to the experimental data of Klevenhagen et al. [Phys. Med. Biol. 27, 263-373 (1982)], although the former are generally lower than the latter. When the typical energy spread of clinical electron beams is taken into account, the difference between the experimental and the calculated values is reduced. The present results also show the same trend of increase of the backscatter factor with increasing energy as observed by Klevenhagen et al. in some series of measurements for the lead backscatterer at the lowest energies. This is explained by the rapid buildup of the dose with depth for electrons of low initial energies incident on the full polystyrene medium.

Electrons↗
PubMedDate not supplied

Clinical value of tumor markers for early detection of recurrence in patients with cervical adenocarcinoma and adenosquamous carcinoma.

OBJECTIVE: The clinical value of tumor markers for early detection of recurrence was investigated in 32 patients with cervical adenocarcinoma or adenosquamous carcinoma who had recurrent tumors. METHODS: Serum levels of CA 125, CA 19-9, carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCC), in addition to clinical status at the time of recurrence were investigated. RESULTS: Among the 32 patients, 26 had no symptoms at the time of recurrence. In 20 patients, elevated serum levels of tumor markers were the first sign of recurrence. In 21 patients with recurrent adenocarcinoma, the positive rates were 14% (CA 125), 62% (CA 19-9), 29% (CEA), and 5% (SCC). There were 71% of cases positive for CA 19-9 and/or CEA. In 11 patients with recurrent adenosquamous carcinoma, the corresponding positive rates were 37% (CA 125), 46% (CA 19-9), 64% (CEA), and 55% (SCC), with 100% positive for CA 19-9, CEA, and/or SCC. CONCLUSIONS: The combination of CA 19-9 and CEA is probably the most promising for detection of recurrent cervical adenocarcinoma. For adenosquamous carcinoma, the additional use of SCC is recommended.

Adenocarcinoma↗
PubMedDate not supplied

Transesophageal pulsed Doppler echocardiographic study of pulmonary venous flow in mitral stenosis.

For evaluation of pulmonary venous flow (PVF) in mitral stenosis, transthoracic and transesophageal echocardiography were performed in 33 patients with mitral stenosis and 20 normal controls. The peak systolic flow velocity of the PVF was significantly lower in patients with mitral stenosis and atrial fibrillation. The peak diastolic flow velocity of the PVF was significantly lower in the patients with mitral stenosis than in normal controls. The diastolic wave recorded as laminar flow in the mitral stenosis group showed a peak in the rapid filling phase with a gradually descending slope of velocity during mid to late diastole. There was a significant negative correlation between the peak diastolic flow velocity of the PVF and the pressure half time from transmitral flow obtained by continuous wave Doppler in the mitral stenosis group. These results demonstrate that evaluation of the PVF is helpful in understanding hemodynamic events between the left atrium and left ventricle in patients with mitral stenosis.

Adult↗
PubMedDate not supplied

Müllerian adenosarcoma of the uterus: report of a case with imprint cytology.

BACKGROUND: Müllerian adenosarcoma is a rare morphologic variant of uterine sarcoma that, although well described histologically, is scarcely mentioned in the cytologic literature. CASE: A 75-year-old female was suspected of having atypical endometrial hyperplasia on an endometrial smear. However, subsequent imaging techniques revealed the presence of a bulky, polypoid mass filling the uterine cavity. On pathologic examination of the hysterectomy specimen, the polypoid tumor was diagnosed as mullerian adenosarcoma, homologous, with sarcomatous overgrowth, in which the sarcomatous component was compatible with high grade endometrial stromal sarcoma. Imprint smears of the tumor consisted of two morphologic patterns, sarcomatous and glandular. The sarcomatous tumor cells, with coarse chromatin and relatively scant cytoplasm, formed small aggregates or appeared alone. These cells were semiround or oval and had conspicuous nucleoli. In addition to these observations, small and large clusters of glandular cells with mild atypism were interspersed with the sarcomatous cells. CONCLUSION: Cytologic examination of müllerian adenosarcoma well reflects its pathologic features.

Adenosarcoma↗
PubMedDate not supplied

Peripheral primitive neuroectodermal tumor of the vulva: report of a case with imprint cytology.

BACKGROUND: Peripheral primitive neuroectodermal tumor (PNET) of the vulva is an extremely rare disease, and, to our knowledge, only two cases have been previously reported. CASE: A 45-year-old woman presented with a mass in the right labium major. Three years after removal of the tumor, she noticed a new lesion in the same place and underwent a partial vulvectomy. The imprint cytology of the recurrent tumor showed a monomorphic appearance, composed of small round cells with scant cytoplasm against a hemorrhagic background. These tumor cells were loosely connective, but rosettelike structures were observed focally. On pathologic examination, the neoplasm was composed of small round tumor cells showing sinusoidal, diffuse or micropapillary growth. Immunohistochemically, the neoplastic cells stained positively for neuron-specific enolase, vimentin and HBA 71 and negatively for cytokeratin, HBA 45 and muscle-specific actin. The morphologic characteristics of the disease were well expressed in the imprint cytology, and this influenced the selection of immunohistochemical studies. CONCLUSION: Cytologic examination for vulvar tumors, even imprint cytology, can be a useful tool in obtaining an accurate pathologic diagnosis of a rare disease, such as peripheral PNET.

Antigens, Neoplasm↗
PubMedDate not supplied

Papillary hypertrophy of the palatine tonsils.

Papillary hypertrophy of the tonsils is one of the rare abnormalities of the palatine tonsils. Since the first reports of papillary hypertrophy of the tonsils by Ogino and Matsui, only 30 cases of this disease have been reported in Japan. The etiology of papillary hypertrophy remains a myster. A 5-year-old female visited our clinic with a complaint of obstructive feeling in the throat. Papillary surface of the palatine tonils were noticed. Tonsillectomy and adenoidectomy were performed under general anesthesia on October 25, 1977. the histopathological examination of the tonsils revealed the lymphoid hyperplasia with poor subepithelial connective tissues. Only slight chronic inflammation was present. This papillary hypertrophy of the tonsils was found in 13 members (6 male, 7 female) of her family pedigree. Genetical analysis of the pedigree showed this disease is transmitted by an autosomal dominant gene.

Adolescent↗
PubMedDate not supplied

Immunological function of human tonsil. Surface topology of human tonsil lymphocytes using the scanning electron microscope (SEM).

The surface topology of the lymphocytes in human tonsils was performed by means of the scanning electron microscope (SEM). It was revealed that human tonsils consist of both 40.7% villous and 26.6% smooth surface lymphocytes. In general, the percentage results agree with those of E and EAC binding lymphocytes of human tonsils, as previously reported. Our serial experiments using immunological techniques proved the existence of two lymphocytes (T and B cell) having immunological roles.

Adolescent↗
PubMedDate not supplied

HLA-DR antigen expression in tonsillar epithelium. With special reference to focal infection.

Palmoplantar pustulosis (PPP) has long been regarded as a tonsillar focal infection because tonsillectomy is so effective in its treatment. Immune mechanisms of focal infection have been discussed mainly with regard to humoral immunity as an autoimmune disease. The present immunological study demonstrates the expression of HLA-DR antigen in tonsillar epithelium. The patterns of the HLA-DR antigen appearance in the epithelium were categorized into 4 types, and the intensity was compared between hypertrophic tonsils, recurrent tonsillitis, and tonsils with PPP. In addition, paired fluorescent staining, a combination of CD3 and anti-HLA-DR antibodies, was performed. The activity of intraepithelial T-lymphocytes was determined as an index of the HLA-DR antigen expression. In an age matching study, HLA-DR antigen appeared in high intensity in tonsils with PPP. A close correlation was found between the appearance of HLA-DR antigens and activation of infiltrating T-lymphocytes. These findings suggest that the tonsillar epithelium plays an important role in focal infection.

Child↗
PubMedDate not supplied

Immunoregulatory effects of the antitumor polysaccharide lentinan on Th1/Th2 balance in patients with digestive cancers.

BACKGROUND: Recent studies demonstrated that patients with advanced cancer may have impaired cell-mediated immunity caused by an imbalance between Th1 and Th2 responses. We evaluated the ability of lentinan (LNT) to modulate Th1 and Th2 responses in patients with digestive cancers. METHODS: Peripheral blood samples were collected preoperatively from 28 patients with digestive cancers before and after intravenous administration of LNT (2 mg x 3 times/week). The proportions of CD4+ T-cells producing intracellular cytokines were determined with flow cytometry. RESULTS: After LNT treatment, CD4+ IFN-gamma+ T-cell percentages increased significantly (p < 0.05), whereas CD4+ IL-4+ T-cell and CD4+ IL-6+ T-cell percentages decreased significantly (p < 0.02). No significant change occurred in proportions of CD4+ IL-10+ T-cells. The after/before LNT treatment percentages ratio of CD4+ IFN-gamma+ T-cells correlated negatively with that of CD4+ IL-4+ T-cells (p < 0.01). The after/before treatment percentage ratio of CD4+ IL-4+ T-cells correlated positively with that of CD4+ IL-6+ T-cells (p < 0.05). CONCLUSION: LNT apparently can cancel Th2-dominant condition in patients with digestive cancers and may improve the balance between Th1 and Th2.

Adjuvants, Immunologic↗
PubMedDate not supplied

Delay method of implantation enhances implant-bone binding: a comparison with the conventional method.

This report compares the conventional and delay methods of implantation, evaluating the bone formation around a dense apatite implant. In the conventional method, the implant is placed immediately after the cavity is prepared. In the delay technique, the implant is placed 2 weeks after preparation. This study found that many new thin trabeculae and capillaries formed around the cavity during the delay period, while none had formed at the time of implantation using the conventional method. The delay method showed earlier and wider bone formation, and less surrounding fibrous encapsulation. These results indicate that the delay technique can be an efficient method for establishing good bone binding.

Animals↗