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Biomedical subjects

T Tabata

Publications and source records attributed to T Tabata.

At least 325 records · Page 18Linked to original sources
PubMed1984

Immunohistological studies on tonsils with recurrent tonsillitis and focus-tonsil with pustulosis palmaris et plantaris.

By use of monoclonal antibodies and anti-immunoglobulin antibodies, the distributions of 15 adult tonsils with recurrent inflammation and palmoplantar pustulosis as focus-tonsil were investigated. The avidin-biotin-peroxidase complex (ABC) method was utilized throughout the experiment. Monoclonal antibodies of the Leu and OKT series revealed the location of T and B cell subsets characteristic in the tonsils with chronic inflammation and the focus tonsils with pustulosis palmaris et plantaris (PPP). In vitro sensitization of tonsil tissues was performed with crude antigen from tonsillar epithelium. Tonsil tissues with PPP demonstrated a significant increase in S-IgD-bearing lymphocytes and esterase-positive cells in the mantle zones of follicles, although the tissues of recurrent tonsillitis showed no such effects. It was speculated that tonsils with focal infections are usually standby for the production of antibodies against tonsillar epithelial antigens.

Adult↗
PubMed1983

The structural organization and DNA sequence of a wheat histone H4 gene.

Some wheat histone H4 genes have been cloned from a Charon 4 wheat genomic DNA library using sea urchin histone H4 DNA as a probe. DNA sequence analysis of a cloned gene showed that the deduced amino acid sequence of wheat histone H4 protein was identical to that of pea. The 5' end of wheat histone H4 mRNA was mapped on the cloned gene by the S1-procedure. Southern blotting analysis of the genomic DNA indicated that histone H4 genes were reiterated 100 to 125 times per hexaploid wheat genome.

Amino Acid Sequence↗
PubMed1983

Laminar distribution and the response of superior colliculus neurons to stimulation of the periodontal ligament in the rabbit.

Unit discharges of superior colliculus neurons fired by electrical stimulation of the periodontal ligament and/or mechanical stimulation of the mandibular incisor tooth were extracellularly recorded, and their laminar distribution and response properties were examined. The neurons were widely distributed in the deep layer of the anterior two-thirds of the superior colliculus. Most of them were located in the lateral site of the profound layer, a few in the lateral site of the intermediate layer. Their locations correspond to the lower nasal quadrant of the visual field. The mean first-spike latency of the intermediate layer neurons (7.2 ms) elicited by electrical stimulation of the periodontal ligament was shorter than that of the profound-layer neurons (13.8 ms). About one-third of the neurons were suppressed by conditioning electrical stimulation of the optic chiasma. These results suggested that in addition to visual, auditory, and body surface tactile sensations, intraoral somesthetic sensations also participate in the functioning of the superior colliculus which appears to play a role in orienting the animal toward visual, somesthetic, and auditory stimuli.

Animals↗
PubMed1983

Effects of acute exercise on insulin binding to erythrocytes in normal men.

Ten normal men were subjected to acute mild and moderate exercise tests, and the insulin binding to erythrocytes was determined before and immediately after exercise and also 10, 30 and 60 minutes after exercise in each test. The insulin binding significantly increased immediately after acute moderate exercise and did not increase immediately after acute mild exercise. In contrast, it decreased below the basal level at 30 and 60 minutes in each test. The changes in insulin receptor binding were due mainly to an alteration in insulin receptor affinity rather than a change in receptor number. These results suggest that isolated erythrocytes may be of some value for study of the effect of physical exercise on the insulin receptor.

Adult↗
PubMed1983

A marked change in insulin binding to rat thymic lymphocytes by fractionation of the cells into two subsets.

As compared with the pre-separated thymic lymphocyte (TL) population, a marked reduction of insulin binding was found in the two fractions [supernatant lymphocytes (SL) and precipitate lymphocytes (PL)] separated by low-speed differential centrifugation from the TL population. The reduction in insulin binding to SL or PL appeared to be due to a decrease in the affinity rather than a decrease in the number of insulin receptors. The reduced insulin binding was enhanced to near the level of the TL population when SL and PL were mixed and then incubated for 90 min at 37 degrees C. Moreover, when the cell-free supernatant from the mixed and incubated fraction was added to SL and PL respectively, the insulin binding to each fraction was found to be enhanced.

Animals↗
PubMed1983

Pustulosis palmaris et plantaris. With reference to the cross-reactivity between tonsillar epithelium antigen and skin antigen.

Though it is well known that pustulosis palmaris et plantaris (PPP) is one of skin diseases caused by focal infection of the tonsils, its etiology remains unknown. The purpose of this study was to elucidate the role of the tonsils in the pathogenesis of PPP, by using histological and immunological techniques. Our findings were as follows: The common histological findings in tonsillar lacunae of patients with PPP were pus plugs, pronounced infiltration of polymorphonuclear cells and mononuclear cells, desquamation of keratinized squamous cells, uneven thickness of the epithelium, and inflammation of the subepithelial area. By applying Arthur's method, skin extracts of sole (S) and epithelial extracts of tonsillar lacunae (T) were prepared as antigens for rabbit immunization. Cross-reactivity between skin extract of sole and epithelial extract of tonsils was tested using the Ouchterlony technique. Anti-T antisera reacted to both T and S. Anti-S antisera reacted similarly to T and S. Direct and indirect immunofluorescence studies using anti-T and anti-S antisera revealed positive staining either in the lacunal epithelium of tonsil or in the corneous, granular and papillary layers of sole. As regards the pathogenesis, it is suggested that the antigenic modification of tonsillar epithelium caused by various stimuli produces cells and/or antibodies so as to challenge against skins.

Antibodies↗
PubMed1983

[Angiographic findings of atrophic cerebral disorders in children].

Angiographic findings of the cerebral atrophy in children are discussed. Cerebral angiographies were performed on 20 patients, ranging from 6 months to 16 years of age. Their clinical diagnoses were H-H-E syndrome (4 cases), sequelae of meningoencephalitis (2), sequelae of head trauma (3), infantile spasms (2) and others (9). Final radiological diagnoses of these cases were hemiatrophy (14 cases), generalized atrophy (2) and focal atrophy (4). Circulation time, caliber of arteries, degree of opacification in cortical and deep veins and early filling of deep veins were investigated on angiogram. Slow circulation of cerebral blood flow was shown in 10 cases and normal circulation in 10 cases. Arterial narrowing was observed more frequently in slow circulation group. In cases with hemiatrophy, small caliber of the middle cerebral arteries and slow circulation on the atrophic hemisphere were demonstrated, but no abnormality on the normal side. Deep veins were prominently opacified in cases which showed poor cortical veins, the other way cortical veins were prominent in cases which showed poor visualization of deep veins. Cortical veins and deep veins may compensate each other in cerebral venous drainage. In most cases of slow circulation, dominant opacification of deep veins were visualized and these veins already appeared in arterial phase, but cortical veins had a tendency of poor opacification. These venous drainage patterns are similar to those of Sturge-Weber syndrome. Causes of these vascular changes are unknown. But they may play an important role in cerebral atrophic disorders.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗
PubMed1981

Metabolism of isoniazid and free hydrazine formation in isolated rat hepatocytes.

Isoniazid (INH) was incubated with isolated rat hepatocytes, and the amounts of acetyl-INH, monoacetylhydrazine, diacetylhydrazine and hydrazine formed were determined by gas chromatography-mass spectrometry (GC-MS). Subsequent analyses of kinetic parameters of metabolic pathways and enzymological study of rat liver homogenate revealed that hydrazine was formed preferentially from INH, catalyzed by soluble hydrolytic enzymes.

Animals↗
PubMed1981

Tissue distribution of isoniazid and its metabolites in rats.

Distribution of isoniazid and its metabolites was observed in the liver, kidney, lung and plasma after the subcutaneous administration of isoniazid to rats. The tissue levels of isoniazid, acetylisoniazid, acetylhydrazine, 1,2-diacetylhydrazine and hydrazine were determined by mass fragmentography using a gas chromatograph-mass spectrometer equipped with a multiple ion detector-peak matcher. Using the compounds labeled with a stable isotope as an internal standard, namely the isotope dilution method, made it possible to estimate trace amounts of these metabolites in the tissues. The amount of hydrazine was much less than the other hydrazines, but the metabolite which is well known as a mutagen, could be successfully detected in the tissues and plasma. The greater part of free hydrazine is formed through a direct hydrolysis of isoniazid. The isoniazid-hydrolyzing activity was found to be significantly higher in the liver homogenate. This suggested that hydrazine formation is mainly caused by hepatic hydrolysis.

Absorption↗
PubMed1981

Occlusion of full cast crown at the intercuspal position.

The IP-Checker type MS capable of measuring the height of a crown at the intercuspal position (IP) was invented. The following observations were obtained. 1. The intercuspal position is stable within 5 micrometers. 2. The intercuspal positions shows a higher stability under slight biting than under heavy biting. Under this condition, the teeth show a displacement of about 20 micrometers by the distortion of the periodontal membrane. 3. The crown made by the ordinary procedure is about 30 micrometers higher at the intercuspal position. Therefore, an occlusal adjustment is always necessary. 4. With the current method of occlusal adjustment, adjustment of the crown to a definite height with the maximum error of 10 micrometers is possible in the oral cavity.

Adult↗