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Biomedical subjects

T T Tang

Publications and source records attributed to T T Tang.

49 records · Page 3Linked to original sources
PubMed1975

Reye syndrome. A correlated electron-microscopic, viral, and biochemical observation.

Liver biopsy specimens of two patients with Reye syndrome were examined for ultrastructural features, viral isolation, and urea-cycle enzyme activity. Concurrent presence of herpes-like virus and myxovirus/paramyxovirus was demonstrated by electron microscopy, and viral infections were confirmed by isolation or serologic tests. A concomitant hepatic ornithine transcarbamoylase deficiency was also noted. The pathogenesis in these instances seems to consist of an initial synergistic insult on the liver by mixed types of viruses and subsequent breakdown of urea cycle, Krebs cycle, and possible other hepatic functions. An exodus of glycogen granules into the hepatic spaces of Disse and sinusoids suggests that the viruses have injured the plasma membranes as well as the mitochondria of hepatocytes. Since Kapila et al reported similar disorders five years before Reye et al, the name of Kapila-Reye disease is suggested.

Adolescent↗
PubMed1975

Chronic myopathy associated with coxsackievirus type A9. A combined electron microscopical and viral isolation study.

Virus-like crystalline structures in human skeletal muscles have been observed by many electron microspists, but no viruses have been isolated and identified in such cases. An 11-year-old girl who had had muscular weakness and physical retardation since early infancy died of pneumonia due to atrophy of diaphragmatic and intercostal muscles. Electron microscopy of these muscles revealed a heavy infiltration of picornavirus-like particles that measured 19 to 23 nm in diameter. Subsequent inoculation of primary human-amnion cells with a sonic-treated suspension of the patient's diaphragmatic muscle induced an enterovirus-like cytopathic effect. The isolate was identified with use of Lim-Benyesh--Meinick enterovirus typing serum pools as coxsackievirus Type A-9. This viral isolation supports the belief that the organized electron-dense particles in human muscle are indeed virions.

Animals↗